Chemical composition and antioxidant capacity of Mentha essential oils from Morocco


J. Pharm. Pharmacogn. Res., vol. 12, no. 6, pp. 1021-1039, Nov-Dec 2024. DOI: Original Article A comparative study of the chemical composition and antioxidant capacity of the essential oils from three species of Mentha cultivated in Morocco [Estudio comparativo de la composición química y la actividad antioxidante de los aceites esenciales de tres especies … Continue reading Chemical composition and antioxidant capacity of Mentha essential oils from Morocco

J. Pharm. Pharmacogn. Res., vol. 12, no. 6, pp. 1021-1039, Nov-Dec 2024.


Original Article

A comparative study of the chemical composition and antioxidant capacity of the essential oils from three species of Mentha cultivated in Morocco

[Estudio comparativo de la composición química y la actividad antioxidante de los aceites esenciales de tres especies de Mentha cultivadas en Marruecos]

Arrahmouni Rayan1, Ouazzani Chadia1*, Er-Ramly Azzedine2, Moustaghfir Abdellah2, Benchama Zakaria3, Elamrani Abdelaziz3, Benkhouili Fatima Zahra4, El-Guourrami Otman5, Dami Abdallah1, Balouch Lhousaine1

1Laboratory of Biochemistry and Molecular Biology, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Morocco.

2Laboratory of Odontological Biomaterials and Nanotechnology, Faculty of Dental Medicine, Mohammed V University in Rabat, Morocco.

3Laboratory of Organic Synthesis, Extraction and Valorization, Faculty of Sciences Ain Chock, Hassan II University of Casablanca, Morocco.

4Laboratory of Medicinal Chemistry, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Morocco.

5Laboratory of Analytical Chemistry, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Morocco.



Context: Mentha species are well known for their health benefits. Products extracted from aromatic plants of this genus (Mentha) are increasingly being studied for their active constituents in order to replace synthetic products that are harmful to health.

Aims: To determine the chemical composition, physicochemical parameters, and antioxidant properties of essential oils of M. spicata, M. piperita, and M. pulegium. These plants were collected from three different geographical areas in the Rabat-Sale-Kenitra region of Morocco, with an additional focus on analyzing the fluctuation of their chemical composition based on their locations.

Methods: Essential oils obtained through hydrodistillation of the fresh aerial parts of the plants were analyzed via gas chromatography and gas chromatography-mass spectrometry. The antioxidant capacity was measured by several chemical tests: DPPH, ABTS, and FRAP.

Results: Multiple major components were identified, showcasing variations in composition between species as well as between plants of the same species. M. spicata was characterized by carvone, piperitone, 1,3,8-p-menthatriene; while M. piperita features linalool, D-carvone, 1,3,8-p-menthatriene; and M. pulegium had a single major component which is pulegone. To the best of our knowledge, it is assumed that a new set of chemotypes may be defined based on the geographical regions studied. The examined essential oils demonstrated notable antioxidant efficacy.

Conclusions: These findings suggest the potential use of extracts from these plants as an alternative to synthetic chemical products. Therefore, they could find applications in complementary medicine as well as in the pharmaceutical and food industries.

Keywords: antioxidant capacity; chemical composition; essential oils; Mentha piperita; Mentha pulegium; Mentha spicata.

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Contexto: Las especies de Mentha son bien conocidas por sus beneficios para la salud. Los productos extraídos de las plantas aromáticas de este género (Mentha) son cada vez más estudiados por sus constituyentes activos con el fin de sustituir los productos sintéticos perjudiciales para la salud.

Objetivos: Determinar la composición química, los parámetros fisicoquímicos y las propiedades antioxidantes de los aceites esenciales de M. spicata, M. piperita y M. pulegium. Estas plantas se recolectaron en tres zonas geográficas diferentes de la región marroquí de Rabat-Sale-Kenitra, con el objetivo adicional de analizar la fluctuación de su composición química en función de su ubicación.

Métodos: Los aceites esenciales obtenidos por hidrodestilación de las partes aéreas frescas de las plantas se analizaron mediante cromatografía de gases y cromatografía de gases-espectrometría de masas. La capacidad antioxidante se midió mediante varias pruebas químicas: DPPH, ABTS y FRAP.

Resultados: Se identificaron múltiples componentes principales, mostrando variaciones en la composición entre especies, así como entre plantas de la misma especie. M. spicata se caracterizaba por carvona, piperitona, 1,3,8-p-menthatrieno; mientras que M. piperita presenta linalol, D-carvona, 1,3,8-p-menthatrieno; y M. pulegium tenía un único componente principal que es la pulegona. Hasta donde sabemos, se supone que puede definirse un nuevo conjunto de quimiotipos en función de las regiones geográficas estudiadas. Los aceites esenciales examinados demostraron una notable eficacia antioxidante.

Conclusiones: Estos hallazgos sugieren el uso potencial de los extractos de estas plantas como alternativa a los productos químicos sintéticos. Por lo tanto, podrían encontrar aplicaciones en medicina complementaria, así como en las industrias farmacéutica y alimentaria.

Palabras Clave: aceites esenciales; capacidad antioxidante; composición química; Mentha piperita; Mentha pulegium; Mentha spicata.

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Citation Format: Rayan A, Chadia O, Azzedine E, Abdellah M, Zakaria B, Abdelaziz E, Zahra BF, Otman E, Abdallah D, Lhousaine B (2024) A comparative study of the chemical composition and antioxidant activity of the essential oils from three species of Mentha cultivated in Morocco. J Pharm Pharmacogn Res 12(6): 1021–1039.

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