J Pharm Pharmacogn Res 2(Suppl. 1): S32, 2014
Special supplement with the abstract book of LATINFARMA 2013
CO 053: SYNTHESIS, CHARACTERIZATION AND DRUG DELIVERY PROFILE OF MAGNETIC PLGA-PEGPLGA/MAGHEMITE NANOCOMPOSITE
Pereira ED1, Souza FG Jr1, Pinto JC2, Cerruti R1, Santana C1.
The kinetics and spatial controls of drug delivery offers many advantages compared to conventional methods. These delivery systems often use biocompatible magnetic nanoparticles as maghemite to promote spatial control and synthetic biocompatible polymers as drug carriers to promote a kinetic control of this release. This study was focused study of the magnetic field influence on the release profile of cotrimoxazole inserted in PLGA-PEG-PLGA/maghemite nanocomposites prepared by melt mixing. The synthesized samples were prepared and characterized by 1H-NMR, FTIR, XRD, and magnetic force. The drug release profile was monitored by UV analysis along 6 hours with and without magnetic field. The release profile of the drug showed to be sustained and the presence of maghemite, in the presence of a magnetic field, were able to perform a magnetic constriction of the material, making the drug release faster than in the absence of the magnetic field. This release behavior may be useful to perform a fine tuning of the system, allowing the easier adjustment of the speed and amount of released drug, improving medical treatments and even the welfare of the patients.