J. Pharm. Pharmacogn. Res., vol. 12, no. 3, pp. 477-486, May-Jun 2024.

DOI: https://doi.org/10.56499/jppres23.1812_12.3.477

Original Article

Comparative efficacy of bakuchiol oil and encapsulated bakuchiol cream on facial skin quality: A 28-day pilot study

[Eficacia comparativa del aceite de bakuchiol y la crema de bakuchiol encapsulado en la calidad de la piel facial: Un estudio piloto de 28 días]

Mediana Hadiwidjaja^1,2, Eliza Romadhona¹, Yulianto¹, Novenia A. Chauwito², Meva Gustina E. Sidauruk², Rey Kardiono², Christina Avanti^1*

¹Department of Pharmaceutics, University of Surabaya, Surabaya, 60293, Indonesia.

²Research and Development Lab, Infinisia Sumber Semesta, Jakarta, 11840, Indonesia.

*E-mail: c_avanti@staff.ubaya.ac.id

Abstract

Context: Along with the rapid growth of the beauty product industry, the community highly favors the use of plants as beauty ingredients and facial treatments. Bakuchiol, a lipid-soluble compound derived from Psoralea corylifolia is a gentle alternative to retinol in anti-aging skincare. To enhance its penetration into the skin, bakuchiol is formulated in liposomes through encapsulation technology.

Aims: To compare the efficacy of 0.5% bakuchiol oil and encapsulated 0.5% bakuchiol cream formula on facial skin quality.

Methods: The subjects consisted of 17 respondents, aged 25-45 years, with various skin types. Two creams, 0.5% bakuchiol oil cream and encapsulated 0.5% bakuchiol cream, were applied twice daily in the split face for 28 days. The study utilized the A-One Tab Skin Analyzer device to measure facial skin quality by scanning facial moisture, pores, sebum, and wrinkles levels on days 0, 14, and 28. Data obtained in the form of numerical values were analyzed using a comparative method employing both parametric and non-parametric methods with the aid of the SPSS software.

Results: The study results indicated that both creams enhanced skin moisture, reduced pore size, and improved wrinkle scores. However, the encapsulated bakuchiol cream performed better in minimizing pore size, sebum levels, and wrinkle scores.

Conclusions: The study findings imply that the use of encapsulated 0.5% bakuchiol cream formulation had a more pronounced effect on improving facial skin quality compared to the 0.5% bakuchiol oil cream formulation, signifying the superior efficacy of the former.

Keywords: anti-aging; bakuchiol oil; encapsulated; skin quality.

Resumen

Contexto: Junto con el rápido crecimiento de la industria de productos de belleza, la comunidad está muy a favor del uso de plantas como ingredientes de belleza y tratamientos faciales. El bakuchiol, un compuesto liposoluble derivado de la Psoralea corylifolia, es una alternativa suave al retinol en el cuidado antienvejecimiento de la piel. Para mejorar su penetración en la piel, el bakuchiol se formula en liposomas mediante tecnología de encapsulación.

Objetivos: Comparar la eficacia del aceite de bakuchiol al 0,5% y la fórmula en crema de bakuchiol encapsulado al 0,5% en la calidad de la piel del rostro.

Métodos: Los sujetos fueron 17 encuestados, de entre 25 y 45 años, con diversos tipos de piel. Se aplicaron dos cremas, crema de aceite de bakuchiol al 0,5% y crema de bakuchiol encapsulado al 0,5%, dos veces al día en la cara dividida durante 28 días. El estudio utilizó el dispositivo A-One Tab Skin Analyzer para medir la calidad de la piel del rostro mediante el escaneado de los niveles de humedad, poros, sebo y arrugas en los días 0, 14 y 28. Los datos obtenidos en forma de valores numéricos se analizaron mediante un método comparativo que empleaba métodos paramétricos y no paramétricos con ayuda del programa informático SPSS.

Resultados: Los resultados del estudio indicaron que ambas cremas mejoraron la hidratación de la piel, redujeron el tamaño de los poros y mejoraron la puntuación de las arrugas. Sin embargo, la crema de bakuchiol encapsulado obtuvo mejores resultados en la reducción del tamaño de los poros, los niveles de sebo y las puntuaciones de las arrugas.

Conclusiones: Los resultados del estudio implican que el uso de la formulación en crema de bakuchiol encapsulado al 0,5% tuvo un efecto más pronunciado en la mejora de la calidad de la piel facial en comparación con la formulación en crema de aceite de bakuchiol al 0,5%, lo que significa la eficacia superior de la primera.

Palabras Clave: antienvejecimiento; aceite de bakuchiol; encapsulado; calidad de la piel.

 

https://jppres.com/jppres/pdf/vol12/jppres23.1812_12.3.477.pdf

Citation Format: Hadiwidjaja M, Romadhona E, Yulianto, Chauwito NA, Sidauruk MGE, Kardiono R, Avanti C (2024) Comparative efficacy of bakuchiol oil and encapsulated bakuchiol cream on facial skin quality: A 28-day pilot study. J Pharm Pharmacogn Res 12(3): 477–486. https://doi.org/10.56499/jppres23.1812_12.3.477

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