Honey effect on acute respiratory infections in adults

Excerpt:


J. Pharm. Pharmacogn. Res., vol. 12, no. 4, pp. 647-658, Jul-Aug 2024. DOI: https://doi.org/10.56499/jppres23.1933_12.4.647 Original Article Therapeutic effect of honey on acute respiratory infections in adults [Efecto terapéutico de la miel en las infecciones respiratorias agudas en adultos] Ahmed Ouaamr1,2*, Mouna Mekkaoui1, El Hassane Ouaalaya3,4, Aziz Mengad5, Yahya Cherrah6, Katim Alaoui1 1Pharmacodynamics Research Team ERP, … Continue reading Honey effect on acute respiratory infections in adults

J. Pharm. Pharmacogn. Res., vol. 12, no. 4, pp. 647-658, Jul-Aug 2024.

DOI: https://doi.org/10.56499/jppres23.1933_12.4.647

Original Article

Therapeutic effect of honey on acute respiratory infections in adults

[Efecto terapéutico de la miel en las infecciones respiratorias agudas en adultos]

Ahmed Ouaamr1,2*, Mouna Mekkaoui1, El Hassane Ouaalaya3,4, Aziz Mengad5, Yahya Cherrah6, Katim Alaoui1

1Pharmacodynamics Research Team ERP, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, University Mohammed V in Rabat, Rabat BP 6203, Morocco.

2High Institute of Nursing Professions and Health Techniques, ISPITS, Tiznit, Morocco.

3High Institute of Nursing Professions and Health Techniques, ISPITS, Agadir, Morocco.

4Laboratory of Cell Biology and Molecular Genetics, Department of Biology, Faculty of Sciences, Ibnou Zohr University, Agadir, Morocco.

5Research Team Pharmacoeconomics and Pharmacoepidemiology, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy of Rabat, Mohamed V University, Rabat BP 6203, Morocco.

6Biopharmaceutical and Toxicological Analysis Research Team, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, University Mohammed V in Rabat, Rabat BP 6203, Morocco.

*E-mail: ouaamr.ahmed@gmail.com, ahmed_ouaamr@um5.ac.ma

Abstract

Context: In Morocco, acute respiratory infections (ARI) are a frequent cause of consultations in the first level health facilities. Scientific reports indicate that honey has an important biochemical therapeutic activity.

Aims: To explore the therapeutic effect of honey on ARI in the Guelmim region of southern Morocco.

Methods: This was a prospective clinical study aiming to compare the therapeutic effect of honey in the population that consumes it versus a control population, at the level of the regional hospital and health centers, the period of the study was between September 2022 and March 2023, All the participants were questioned through a questionnaire and the study of their files and monitoring forms.

Results: The study population was divided into two equal groups of 417 people each. Honey significantly reduced the overall symptom score at Day 5 (p<0.001) in the honey group compared with the reference group, according to the ANOVA test, the significant variables are age, presence of associated diseases, duration of illness, number of consultations for respiratory episodes and current smoking status, the present study also shows that non consumption of honey OR = 15.09 [10.26-22.17], high symptom score at D1 OR = 3.85 [2.37-5.39], frequency of nocturnal cough OR = 4.26 [1.65-10.9], frequency of diurnal cough OR = 3.34 [1.5-7.4], duration of illness OR = 7.12 [3.4-14.6] and type of cough OR = 1.5 [1.04-2.2] were the determinants of high symptom score at Day 5.

Conclusions: Honey was effective in relieving symptoms associated with ARI and may be suggested as an adjuvant treatment in adults.

Keywords: acute respiratory infections; adults; cough; honey; symptom score.

PDF Download

Resumen

Contexto: En Marruecos, las infecciones respiratorias agudas (IRA) son una causa frecuente de consulta en los centros sanitarios de primer nivel. Los informes científicos indican que la miel tiene una importante actividad terapéutica bioquímica.

Objetivos: Explorar el efecto terapéutico de la miel sobre las IRA en la región de Guelmim, en el sur de Marruecos.

Métodos: Se trató de un estudio clínico prospectivo con el objetivo de comparar el efecto terapéutico de la miel en la población que la consume frente a una población control, a nivel del hospital regional y centros de salud, el periodo del estudio fue entre septiembre de 2022 y marzo de 2023, Todos los participantes fueron interrogados mediante un cuestionario y el estudio de sus fichas y formularios de seguimiento.

Resultados: La población de estudio se dividió en dos grupos iguales de 417 personas cada uno. La miel redujo significativamente la puntuación global de los síntomas en el día 5 (p<0,001) en el grupo de miel en comparación con el grupo de referencia, según la prueba ANOVA, las variables significativas son la edad, la presencia de enfermedades asociadas, la duración de la enfermedad, el número de consultas por episodios respiratorios y el hábito de fumar actual, el presente estudio también muestra que el no consumo de miel OR = 15.09 [10,26-22,17], la puntuación elevada de los síntomas en el D1 OR = 3,85 [2,37-5,39], la frecuencia de la tos nocturna OR = 4,26 [1,65-10,9], la frecuencia de la tos diurna OR = 3,34 [1,5-7,4], la duración de la enfermedad OR = 7,12 [3,4-14,6] y el tipo de tos OR = 1,5 [1,04-2,2] fueron los factores determinantes de la puntuación elevada de los síntomas en el quinto día.

Conclusiones: La miel fue eficaz para aliviar los síntomas asociados a las IRA y puede sugerirse como tratamiento coadyuvante en adultos.

Palabras Clave: adultos; infecciones respiratorias agudas; miel; puntuación de los síntomas; tos.

PDF Download
 
Citation Format: Ouaamr A, Mekkaoui M, Ouaalaya E, Aziz M, Cherrah Y, Alaoui K (2024) Therapeutic effect of honey on acute respiratory infections in adults. J Pharm Pharmacogn Res 12(4): 647–658. https://doi.org/10.56499/jppres23.1933_12.4.647
References

Almasaudi SB, Al-Nahari AAM, Abd El-Ghany ESM, Barbour E, Al Muhayawi SM, Al-Jaouni S, Azhar E, Qari M, Qari YA, Harakeh S (2017) Antimicrobial effect of different types of honey on Staphylococcus aureus. Saudi J Biol Sci 24(6): 1255–1261. https://doi.org/10.1016/j.sjbs.2016.08.007

Al-Nahari AA, Almasaudi SB, Abd El-Ghany el SM, Barbour E, Al Jaouni SK, Harakeh S (2015) Antimicrobial activities of Saudi honey against Pseudomonas aeruginosa. Saudi J Biol Sci 22(5). 521–525. https://doi.org/10.1016/j.sjbs.2015.04.006

Al-Waili NS, Salom K, Butler G, Al Ghamdi AA (2011) Honey and microbial infections: A review supporting the use of honey for microbial control. J Med Food 14(10): 1079–1096. https://doi.org/10.1089/jmf.2010.0161

Boutoub O, El-Guendouz S, Manhita A, Dias CB, Estevinho LM, Paula VB, Carlier J, Costa MC, Rodrigues B, Raposo S, Aazza S, El Ghadraoui L, Miguel MG (2021) Comparative study of the antioxidant and enzyme inhibitory activities of two types of Moroccan Euphorbia entire honey and their phenolic extracts. Foods 10(8): 1909. https://doi.org/10.3390/foods10081909

Carr RR, Nahata MC (2006) Complementary and alternative medicine for upper-respiratory-tract infection in children. Am J Health Syst Pharm 63(1): 33–39. https://doi.org/10.2146/ajhp040613

Cianciosi D, Forbes-Hernández TY, Afrin S, Gasparrini M, Reboredo-Rodriguez P, Manna PP, Zhang J, Bravo Lamas L, Martínez Flórez S, Agudo Toyos P, Quiles JL, Giampieri F, Battino M (2018) Phenolic compounds in honey and their associated health benefits: A review. Molecules 23(9): 2322. https://doi.org/10.3390/molecules23092322

Gupta A, Gaikwad V, Kumar S, Srivastava R, Sastry J (2016) Clinical validation of efficacy and safety of herbal cough formulation “Honitus syrup” for symptomatic relief of acute non-productive cough and throat irritation. Ayu 37(3-4): 206–214. https://doi.org/10.4103/ayu.AYU_156_15

Jacobs B, Young NL, Dick PT, Ipp MM, Dutkowski R, Davies HD, Langley JM, Greenberg S, Stephens D, Wang EE (2000) Canadian Acute Respiratory Illness and Flu Scale (CARIFS): Development of a valid measure for childhood respiratory infections. J Clin Epidemiol 53(8): 793–799. https://doi.org/10.1016/s0895-4356(99)00238-3

Mariam SH, Zegeye N, Tariku T, Andargie E, Endalafer N, Aseffa A (2014) Potential of cell-free supernatants from cultures of selected lactic acid bacteria and yeast obtained from local fermented foods as inhibitors of Listeria monocytogenes, Salmonella spp. and Staphylococcus aureus. BMC Res Notes 7: 606. https://doi.org/10.1186/1756-0500-7-606

Ministry of Health (2005) Child health policy, situation analysis. Ministry of Health and Social Protection Rabat, Morocco.

Ministry of Health (2007) Multiple Indicator National Survey and Youth Health. Ministry of Health and Social Protection Rabat, Morocco.

Najat C, Dahouss R (2017) The management of lower respiratory infections in children under 05 years of age at the level of c/s Elmassira, Tayert, and rjaflah and pediatric service, Higher Institute of Nursing and Health Technology Guelmim, Morocco.

Nanda M, Mittal S, Gupta V (2017) Role of honey as adjuvant therapy in patients with sore throat. Natl J Physiol Pharm Pharmacol 7(4): 412–415.

Ouaamr A, Aberhouch N, Cherrah Y, Katim A (2023) The effects of honey on cough and sleep quality in adults with acute respiratory infections. Chinese J Otorhinolaryngol Head Neck Surg 58(5): 873–885.

Paul IM, Beiler J, McMonagle A, Shaffer ML, Duda L, Berlin CM Jr (2007) Effect of honey, dextromethorphan, and no treatment on nocturnal cough and sleep quality for coughing children and their parents. Arch Pediatr Adolesc Med 161(12): 1140–1146. https://doi.org/10.1001/archpedi.161.12.1140

Peterson RA (1995) A meta-analysis of the Cronbach alpha coefficient. J Consumer Res 21(2): 381–391. https://www.jstor.org/stable/2489828

Seçilmiş Y, Silici S (2020) Bee product efficacy in children with upper respiratory tract infections. Turk J Pediatr 62(4): 634–640. https://doi.org/10.24953/turkjped.2020.04.013

Sulaiman SA, Hasan H, Deris ZZ, Wahab MSA, Yusof RC, Naing NN, Othman NH (2011) The benefit of Tualang honey in reducing acute respiratory symptoms among Malaysian Hajj pilgrims: A preliminary study. J ApiProduct ApiMedical Sci 3(1): 38–44.

World Health Organization (2015) World Health Statistics 2015. https://www.who.int/docs/default-source/gho-documents/world-health-statistic-reports/world-health-statistics-2015.pdf [Consulted: 15 December 2023].

© 2024 Journal of Pharmacy & Pharmacognosy Research

Anti-dormant mycobacterial of marine-derived fungi
J. Pharm. Pharmacogn. Res., vol. 13, no. 1, pp. 16-26, Jan-Feb 2025. DOI: https://doi.org/10.56499/jppres24.1953_13.1.16 Original Article Activity of ethyl acetate extracts of marine-derived fungi against active and hypoxia-induced dormant Mycobacterium [Actividad de extractos de acetato de etilo de hongos de origen marino contra Mycobacterium latente activa e inducida por hipoxia] Muhammad Azhari1, Atik Pereztia Litanjuasari1, … Continue reading Anti-dormant mycobacterial of marine-derived fungi
Rift Valley fever virus RdRp inhibition by RNA polymerase inhibitors
J. Pharm. Pharmacogn. Res., vol. 13, no. 1, pp. 1-15, Jan-Feb 2025. DOI: https://doi.org/10.56499/jppres24.1967_13.1.1 Original Article In silico study of RNA polymerase inhibitor drugs for Rift Valley fever virus using RdRp protein as the target [Estudio in silico de fármacos inhibidores de la ARN polimerasa para el virus de la fiebre del valle del Rift … Continue reading Rift Valley fever virus RdRp inhibition by RNA polymerase inhibitors
Probable interaction between levothyroxine and Thymus vulgaris
J. Pharm. Pharmacogn. Res., vol. 12, no. 6, pp. 1196-1198, Nov-Dec 2024. DOI: https://doi.org/10.56499/jppres24.2008_12.6.1196 Case Report Probable interaction between levothyroxine sodium and thyme (Thymus vulgaris), about a case report [Interacción probable entre levotiroxina sódica y tomillo (Thymus vulgaris), sobre un reporte de caso] Nassima Elyebdri1,2*, Sihem Baba Ahmed1, Nessrine Abourejal1, Lotfi Loudjedi3, Assia Bououden3, Nour … Continue reading Probable interaction between levothyroxine and Thymus vulgaris

© 2013-2020 by the authors; licensee JPPRes, Antofagasta, Chile. This journal is an open-access journal distributed under the terms and conditions of the Creative Commons Attribution license-Non Commercial 4.0 international. The content on this site is intended for health professionals. If you are not a health professional, please talk to your doctor about any doubts or concerns regarding your health

Made with ♥ by AVAGAX Studio