Microencapsulation of an antioxidant extract of Lannea microcarpa

J Pharm Pharmacogn Res 2(4): 100-109, 2014.

Original Article| Artículo Original

Microencapsulation by spray drying of Lannea microcarpa extract: Technological characteristics and antioxidant activity.

[Microencapsulación mediante secado por pulverización del extracto de Lannea microcarpa:Características tecnológicas y la actividad antioxidante]

Francesca Sansone, Teresa Mencherini, Patrizia Picerno, Tiziana Esposito, Pasquale Del Gaudio, Paola Russo, Giacomo Pepe, Maria R. Lauro, Rita P. Aquino

Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 84084, Fisciano (SA), Italy.

Context: A functional extract from Lannea microcarpa (Lm), possess interesting antioxidant and anti-inflammatory properties. However, the unprocessed dried extract occurs as sticky and low-water-soluble material showing critical properties for industrial applications. The unprocessed dried extract is not always enough stable to preserve its functional properties, also giving practical difficulties for the manufacturing.

Aims: This research aimed to produce Lm extract microparticles with enhanced functional stability and technological characteristics by spray-drying.

Methods: Lm extract was microencapsulated by spray-drying using a sodium-carboxymethylcellulose (NaCMC) based matrix. Physicochemical and technological characteristics (determined by UV, HPLC, LLS, SEM, DSC, and in vitro dissolution tests), as well as antioxidant properties (DPPH-test) of the resulting powder (LmC) were examined.

Results: The produced spray dried microparticles showed satisfying encapsulation efficiency, good functional stability and enhanced technological properties.

The selected carrier and process conditions led to a stable and handling microencapsulated powder form with improved water dissolution rate. Moreover, the matrix was also able to preserve the antioxidant activity of the phenolic compounds-rich extract.

Conclusions: The made-up powder resulted in a functional component that can be used with great potential in cosmetics, foods or nutraceutical products.

Keywords: Antioxidant; functional stability; in vitro dissolution test; Lannea microcarpa; sodium-carboxymethylcellulose matrix; spray-drying.


Contexto: Un extracto funcional a partir de Lannea microcarpa (Lm), posee propiedades antioxidante y anti-inflamatorias interesantes. Sin embargo, el extracto seco no procesado es pegajoso y el poco soluble en agua, por lo que muestra propiedades críticas para aplicaciones industriales. El extracto seco no procesado no siempre es lo suficientemente estable como para preservar sus propiedades funcionales, dando también dificultades prácticas en el proceso de fabricación.

Objetivos: Esta investigación tuvo como objetivo producir micropartículas del extracto de Lm con estabilidad funcional y características tecnológicas mejoradas mediante secado por aspersión.

Métodos: Este documento informa sobre la encapsulación del extracto de Lm por secado por aspersión en una matriz basada en carboximetilcelulosa sódica (NaCMC). Se examinaron las características físico-químicas y tecnológicas (determinadas por UV, HPLC, LLS, SEM, DSC, y en las pruebas de disolución in vitro), así como las propiedades antioxidantes (prueba de DPPH) del polvo resultante (LMC).

Resultados: Las micropartículas secadas por pulverización mostraron eficacia de encapsulación satisfactoria, buena estabilidad funcional y propiedades tecnológicas mejoradas.
Los vehículos y condiciones de proceso seleccionados condujeron a una forma estable y manejable del polvo microencapsulado con una mejorada velocidad de disolución de agua. Por otra parte, la matriz también fue capaz de preservar la actividad antioxidante del extracto rico en compuestos fenólicos.

Conclusiones: El polvo obtenido resultó en un componente funcional que se puede utilizar con un gran potencial en cosméticos, alimentos o productos nutracéuticos.

Palabras Clave: Antioxidante; estabilidad funcional; Lannea microcarpa; matriz de carboximetilcelulosa; prueba de disolución in vitro; secado por pulverización.

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Citation Format: Sansone F, Mencherini T, Picerno P, Esposito T, Del Gaudio P, Russo P, Pepe G, Lauro MR, Aquino RP (2014) Microencapsulation by spray drying of Lannea microcarpa extract: Technological characteristics and antioxidant activity. J Pharm Pharmacogn Res 2(4): 100-109.
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© 2014 Journal of Pharmacy & Pharmacognosy Research (JPPRes)