J. Pharm. Pharmacogn. Res., vol. 10, no. 4, pp. 616-651, July-August 2022.

DOI: https://doi.org/10.56499/jppres22.1387.10.4.616

Review

Pectinas modificadas con actividad contra el cáncer de colon: Una revisión sistemática de 2010-2021

[Modified pectins with activity against colon cancer: A systematic review from 2010-2021]

Matías Pérez-Loyola, Marisela Valdés-González, Gabino Garrido^*

Departamento de Ciencias Farmacéuticas, Facultad de Ciencias, Universidad Católica del Norte, Angamos 0610, Antofagasta, Chile.

^*E-mail: gabino.garrido@ucn.cl

Abstract

Context: Colon cancer is a serious disease that can be hereditary or arise from exposure to carcinogens in unhealthy food. Current chemotherapy treatment has serious cardiovascular adverse effects, is not always effective, and there may be resistance to treatment. Recently, studies have found an optimal anticancer activity of modified pectins on colon cancer.

Aims: To systematically review the scientific literature, with PRISMA guidelines, of the articles found in the last 11 years, on the potential anticancer effects of pectins on colon cancer.

Methods: PRISMA and Rayyan were used for the selection of studies and a standardized search was followed in four databases with the terms: modified pectins, cancer, therapy. Data extraction was performed using Excel and relevant information on anticancer activity was collected.

Results: In total, 16 articles were included, finding seven in vitro, three mixed and six in vivo studies. The anticancer activity and optimization of the formulation, encapsulation, release of pectin-based drugs were evaluated by different methods in 12 and six articles, respectively. Most of the studies were classified as high quality with the AXIS tool. Furthermore, 11 out of 12 articles showed positive effects of modified pectins on colon cancer both in vivo and in vitro and six out of six articles found positive effects on pectin-based formulations.

Conclusions: The evidence found suggests a beneficial effect of modified pectins on colon cancer, however, more in vivo studies are required.

Keywords: colon cancer; modified pectin; systematic review; therapy.

Resumen

Contexto: El cáncer de colon es una patología grave que puede ser hereditaria o surgir por exposición a carcinógenos en la alimentación no saludable. El tratamiento mediante quimioterapia actual posee efectos adversos cardiovasculares graves, no siempre es efectivo y puede existir resistencia al tratamiento. Recientemente, estudios han encontrado una óptima actividad anticancerígena de las pectinas modificadas sobre cáncer de colon.

Objetivos: Revisar sistemáticamente la literatura científica, con directrices PRISMA, de los artículos encontrados en los últimos 11 años, sobre los potenciales efectos anticancerígenos de las pectinas sobre el cáncer de colon.

Métodos: Se utilizó PRISMA y Rayyan para la selección de estudios y se siguió una búsqueda estandarizada en cuatro bases de datos con los términos: modified pectins, cancer, therapy. La extracción de datos se realizó mediante Excel y se recopilo información relevante sobre la actividad anticancerígena.

Resultados: En total, se incluyeron 16 artículos, encontrándose siete estudios in vitro, tres mixtos y seis in vivo. Se evaluó por diferentes métodos la actividad anticancerígena y la optimización de la formulación, encapsulación, liberación de fármacos a base de pectina, en 12 y seis artículos, respectivamente. Mayoritariamente, los estudios fueron clasificados de alta calidad con la herramienta AXIS. Además, 11 de 12 artículos mostraron efectos positivos de las pectinas modificadas sobre el cáncer de colon tanto in vivo como in vitro y seis de seis artículos obtuvieron efectos positivos en las formulaciones a base de pectina.

Conclusiones: La evidencia encontrada sugiere un efecto beneficioso de las pectinas modificadas sobre el cáncer de colon, sin embargo, se requieren más estudios in vivo.

Palabras Clave: cáncer de colon; pectina modificada; revisión sistemática; terapia.

Citation Format: Pérez-Loyola M, Valdés-González M, Garrido G (2022) Pectinas modificadas con actividad contra el cáncer de colon: Una revisión sistemática de 2010-2021. [Modified pectins with activity against colon cancer: A systematic review from 2010-2021]. J Pharm Pharmacogn Res 10(4): 616–651. https://doi.org/10.56499/jppres22.1387.10.4.616

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