J Pharm Pharmacogn Res 3(suppl. 1): S41, 2015
Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015 September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.
OC-23: PHYTOCHEMICAL STUDY OF Croton linearis JACQ. LEAVES
García J1, Escalona JC1, do Carvallo MG2, de la Vega J3, Rojas J4, Machado R4.
Introduction: Cuban population to treat the fever usually uses leaves from Croton linearis Jacq., but there is almost no information about this plant; that’s why in the present work we accomplish a phytochemical study of C. linearis leaves. Material and Methods: By hydrodistillation-cohobation method, the essential oils were extracted to be characterized by Gas Chromatography – Mass Spectrometry. The non volatile compounds were separated by thin layer chromatography and colum chromatography. The isolated compounds were characterized by Nuclear Magnetic Resonance 1D (1H and 13C NMR), 2D (1H–H COSY, HMQC and HMBC); UV-visible spectroscopy and Mass Spectrometry. Results: Essential oil extraction yield 1.6% being identified 82 compounds with guaiol (7.93%), eudesma-4(15),7-dien-1β-ol (4.94%), guaia-3,10(14)-dien-11-ol (4.52%), selin-4(15),7(11)-diene (4.19%) y el β-elemene (4.13%) as the main constituents. Additionally, seven metabolites were identified as 5-hydroxy-3,7,4′-trimethoxyflavone, tetracosane, hexacosan-1-ol, 2-methyl-2-docosanol, as well as the acids oleic, stearic and the 5,8-dien-tetradecanoic. Conclusions: A total of 89 new compounds for this plant was reported, giving it a great pharmacological potentiality.
Citation Format: García J, Escalona JC, do Carvallo MG, de la Vega J, Rojas J, Machado R (2015) Phytochemical study of Croton linearis Jacq. leaves. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S41. Abstract nr OC-23.