OC-39: MANGIFERIN: THE CHALLENGE OF TRANSFORM A NATURAL ANTIOXIDANT WITH AN EXCELENT PRECLINICAL PHARMACOLOGICAL PROFILE IN NEW PHARMACEUTICAL PRODUCTS

jppres
September 17, 2015
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J Pharm Pharmacogn Res 3(suppl. 1): S57, 2015 Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015 September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba. Oral Communication OC-39: MANGIFERIN: THE CHALLENGE OF TRANSFORM A NATURAL ANTIOXIDANT WITH AN EXCELENT PRECLINICAL PHARMACOLOGICAL PROFILE IN NEW PHARMACEUTICAL PRODUCTS … Continue reading →

J Pharm Pharmacogn Res 3(suppl. 1): S57, 2015

Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015 September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.

Oral Communication

OC-39: MANGIFERIN: THE CHALLENGE OF TRANSFORM A NATURAL ANTIOXIDANT WITH AN EXCELENT PRECLINICAL PHARMACOLOGICAL PROFILE IN NEW PHARMACEUTICAL PRODUCTS

Delgado R¹, Garrido B¹, Hernández I², Rodeiro I², Romero JA¹, Rodríguez JC¹, Quiñones OL¹, Acosta J³, Nuevas L¹, Salomón S¹, Rodríguez C¹, Haegeman G⁴, Vanden Berghe W⁵.

¹Center for Pharmaceutical Research and Drug Development, Ave 26 e/ Ave 51 and Boyeros, Havana, Cuba. E-mail: rdelgado@infomed.sld.cu

²Laboratorio de Farmacologia. Center of Marine Bioproducts (CEBIMAR), La Habana, Cuba.

³Facultad de Química, ISPJAE, La Habana, Cuba.

⁴Laboratory of Eukaryotic Gene Expression and Signal Transduction (LEGEST), Department of Physiology, Ghent University, K.L. Ledeganckstraat 35, B-9000 Gent, Belgium.

⁵Laboratory of Protein Science, Proteomics and Epigenetic Signaling (PPES), Department of Biomedical Sciences, University Antwerp, Campus Drie Eiken, Universiteitsplein 1, Wilrijk, Belgium.

Mangiferin (M) is a very interesting glucosilxanthone, which has been known for its antioxidant, immunomodulatory, antitumoral and anti-inflammatory actions. Precedent investigations showed the results of studies realized with an extract obtained from stem bark and leaves of Mangifera indica L. were mangiferin represent the major bioactive component. In general, mangiferin as active ingredient in Vimang extract and in others natural extract or as compound isolated from different sources, represent an important natural compound with potentialities for pharmaceutical formulations against cancer and anti-inflammatory actions. We studies have demonstrated that mangiferin as a natural xanthone present antiangiogenic activities and these properties could be pharmacological relevant for its use of treatment of some tumors where neovascularization result essentially for the development of the malignance process. Our projects have been orientated for to future development of new phytopharmaceutical drug with mangiferin as active ingredient in different pharmaceutical formulations. Financial Support: VLIR UOS programme Nr. ZEIN2011PR383 and a National project of CIDEM.

Citation Format: Delgado R, Garrido B, Hernández I, Rodeiro I, Romero JA, Rodríguez JC, Quiñones OL, Acosta J, Nuevas L, Salomón S, Rodríguez C, Haegeman G, Vanden Berghe W (2015) Mangiferin: the challenge of transform a natural antioxidant with an excelent preclinical pharmacological profile in new pharmaceutical products. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S57. Abstract nr OC-39.

Toxicity evaluation of Ruta angustifolia leaves ethanolic extract

J. Pharm. Pharmacogn. Res., vol. 11, no. 3, pp. 437-447, May-June 2023. DOI: https://doi.org/10.56499/jppres23.1609_11.3.437 Original Article Acute and repeated dose 28-day oral toxicity of Ruta angustifolia Pers. leaves ethanolic extract in Wistar rats [Toxicidad oral aguda y por dosis repetidas durante 28 días del extracto etanólico de hojas de Ruta angustifolia Pers. en ratas Wistar] Tutik … Continue reading →