J Pharm Pharmacogn Res 3(suppl. 1): S19, 2015
Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015 September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.
OC-58: THE IMPACT OF Ocimum sanctum LINN. LEAF EXTRACT ON SOME BIOMARKERS WITH REFERENCE TO ANTIFERTILITY POTENTIAL IN FEMALE ALBINO RATS
Venkataramanaiah P, Srinivasulu K, Changamma C.
Aim: To study the effect of Ocimum sanctum Linn. leaf extract on some biomarkers with reference to antifertility potential in female albino rats. Methods: The healthy female albino rats were administered with Ocimum sanctum Linn. (Tulasi) leaf extract orally at different dose (100, 200, 300 mg/kg body weight/15 days) and duration (300 mg/kg body weight/30 days). The total proteins, total carbohydrates, total lipids, cholesterol, phospholipids and triglycerides were estimated using standard biochemical methods in control and experimental female albino rat tissues like ovary, uterus, vagina, liver and plasma. Results: The oral administration of ocimum sanctum leaf extract was significantly elevated the ovarian total proteins in group-II, III & IV but in group-V it was reduced. No significant changes observed in ovarian total carbohydrates in group-II & III. But in group – IV (300 mg/kg body weight/day for 15 days) and group – V (300 mg/kg body weight/day for 30 days) there was significant elevation over control. The ovarian and uterine lipids were enhanced as the dose and duration of the extract increases. The elevated cholesterol levels observed in ovary and uterus but at higher and prolonged dose and duration uterine cholesterol levels were depleted. The increased hepatic triglycerides were noticed as the dose and duration increased. Conclusions: Based on these observations it may be concluded that the extract of ocimum sanctum leaf at higher dose and prolonged duration owing to its potent antiestrogenic nature, alters the biochemical milieu of the reproductive tract.
Citation Format: Venkataramanaiah P, Srinivasulu K, Changamma C (2015) The impact of Ocimum sanctum Linn. Leaf extract on some biomarkers with reference to antifertility potential in female albino rats. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S19. Abstract nr OC-58.