J Pharm Pharmacogn Res 3(suppl. 1): S84, 2015
Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015 September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.
OC-72: FIFTEEN YEARS OF EXPERIENCE IN SAFETY ASSESSMENT OF HERBAL EXTRACTS
González Y, Mancebo A, Bada AM, Arteaga ME, González B, Fuentes D, Hernández O, Blanco D, León A.
Introduction: The use of extracts of medicinal plants in Cuba is not an alternative, but an essential component of health care in Cuba. However, as any product intended for human consumption, the risk derived from its single or repeated ingestion must be assessed. In our institution, natural products with different medicinal purposes have been evaluated for 15 years. Objective: The evaluation has focused on the possibility of acute and repeated doses exposure, using the Sprague Dawley rat as biomodel. Material and Methods: In this work were evaluated fifteen medicinal plants. The administrations were performed by intragastric intubation and the tested doses were 2000 mg/kg of body weight in the acute assays, and 1000 mg/kg of body weight in repeated doses, for which in each test was established a control and a treated group. Clinical observations were performed daily, weekly determinations of body weight, and necropsy of all animals at the end of the study, including in the repeated dose studies the evaluating of water and food consumption, the determination of hematological and biochemical parameters, and macroscopic and microscopic analysis of organs and tissues. Results: In this work, we show the main results obtained in the safety assessment of herbal extracts in our institution.
Citation Format: González Y, Mancebo A, Bada AM, Arteaga ME, González B, Fuentes D, Hernández O, Blanco D, León A (2015) Fifteen years of experience in safety assessment of herbal extracts. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S84. Abstract nr OC-72.