J. Pharm. Pharmacogn. Res., vol. 12, no. 3, pp. 548-556, May-Jun 2024.
DOI: https://doi.org/10.56499/jppres23.1902_12.3.548
Original Article
Outpatient prescription drug interactions at a city-affiliated healthcare center in Vietnam
[Interacciones entre medicamentos de venta con receta para pacientes ambulatorios en un centro sanitario municipal de Vietnam]
Minh Cuong Nguyen1, Dao Phuong Nguyen2, Quang Loc Duyen Vo3, Rebecca Susan Dewey4, Minh Trung Nguyen5, Quoc Quan Ly6, Tu Nguyet Tran5*
1Nam Can Tho University, 168 Nguyen Van Cu (extended) Street, Can Tho 900000, Vietnam.
2Tay Do University, 68 Tran Chien Street, Can Tho 900000, Vietnam.
3Can Tho University, Campus II, 3/2 Street, Can Tho 900000, Vietnam.
4University of Nottingham, Nottingham NG7 2RD, United Kingdom.
5Can Tho University of Medicine and Pharmacy, 179 Nguyen Van Cu, Can Tho 900000, Vietnam.
6An Giang Central General Hospital, 60 Ung Van Khiem Street, Long Xuyen 880000, Vietnam.
*E-mail: ttnguyet@ctump.edu.vn
Abstract
Context: Adverse drug interactions increase the risk of hospitalization, treatment costs, unfavorable treatment outcomes, and prolonged hospital stays. However, there are a limited number of studies conducted in city-affiliated healthcare settings in Vietnam.
Aims: To identify drug interactions in outpatient treatment prescriptions at a city-based healthcare center in the southern region of Vietnam.
Methods: A cross-sectional descriptive study was conducted on outpatient treatment prescriptions stored in the outpatient department of a city-affiliated healthcare center from January to June, 2023. The study used two databases for drug interaction checking: the Drug Interactions Checker and Medscape Interactions Checker. Univariate and multivariate regression analyses were used to identify predictors of clinically significant drug interactions.
Results: Among 1203 surveyed prescriptions, 36.7% contained at least one clinically-significant drug interaction, with 3% of prescriptions having severe interactions. The highest frequency of drug interactions involved amlodipine and metformin (9.9%). Patients with five or more prescribed medications (OR = 3.305; 95% CI: 2.320-4.708), hypertension (OR = 7.142; 95% CI: 4.658-10.950), dyslipidemia (OR = 2.242; 95% CI: 1.665-3.020), and non-insulin-dependent diabetes (OR = 2.447; 95% CI: 1.817-3.295) had a higher likelihood of experiencing clinically significant drug interactions.
Conclusions: This study revealed that over one-third of outpatient prescriptions were associated with clinically-significant drug interactions. This study highlights the importance of clinical pharmacists screening prescriptions to detect and reduce interactions, as well as the application of computerized alert systems with intelligent screening software to minimize drug interactions.
Keywords: drug interactions; hospital; outpatient; Vietnam.
Resumen
Contexto: Las interacciones adversas entre medicamentos aumentan el riesgo de hospitalización, los costes del tratamiento, los resultados desfavorables del tratamiento y las estancias hospitalarias prolongadas. Sin embargo, hay un número limitado de estudios realizados en ámbitos de asistencia sanitaria afiliados a la ciudad en Vietnam.
Objetivos: Identificar las interacciones farmacológicas en las prescripciones de tratamiento ambulatorio en un centro sanitario de ciudad de la región sur de Vietnam.
Métodos: Se realizó un estudio descriptivo transversal sobre las prescripciones de tratamiento ambulatorio almacenadas en el departamento de pacientes ambulatorios de un centro de salud afiliado a una ciudad de enero a junio de 2023. El estudio utilizó dos bases de datos para la comprobación de interacciones farmacológicas: Drug Interactions Checker y Medscape Interactions Checker. Se utilizaron análisis de regresión univariantes y multivariantes para identificar predictores de interacciones farmacológicas clínicamente significativas.
Resultados: De las 1203 recetas encuestadas, el 36,7% contenía al menos una interacción farmacológica clínicamente significativa, y el 3% de las recetas presentaba interacciones graves. La mayor frecuencia de interacciones farmacológicas correspondió a amlodipino y metformina (9,9%). Los pacientes con cinco o más medicamentos prescritos (OR = 3,305; IC 95%: 2,320-4,708), hipertensión (OR = 7,142; IC 95%: 4,658-10,950), dislipidemia (OR = 2,242; IC 95%: 1,665-3,020) y diabetes no insulinodependiente (OR = 2,447; IC 95%: 1,817-3,295) tenían una mayor probabilidad de experimentar interacciones farmacológicas clínicamente significativas.
Conclusiones: Este estudio reveló que más de un tercio de las prescripciones ambulatorias se asociaron con interacciones farmacológicas clínicamente significativas. Este estudio pone de relieve la importancia de que los farmacéuticos clínicos revisen las prescripciones para detectar y reducir las interacciones, así como la aplicación de sistemas informatizados de alerta con programas de detección inteligente para minimizar las interacciones farmacológicas.
Palabras Clave: interacciones farmacológicas; hospital; pacientes ambulatorios; Vietnam.
Citation Format: Nguyen MC, Nguyen DP, Vo QLD, Dewey RS, Nguyen MT, Ly QQ, Tran TN (2024) Outpatient prescription drug interactions at a city-affiliated healthcare center in Vietnam. J Pharm Pharmacogn Res 12(3): 548–556. https://doi.org/10.56499/jppres23.1902_12.3.548
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