J Pharm Pharmacogn Res 3(suppl. 1): S93, 2015
Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015 September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.
PPP-01: ANTIALLODYNIC EFFECT OF MANGIFERIN IN NEUROPATHIC PAIN
Espinosa de los Monteros-Zuñiga A, Izquierdo-Sánchez T, Godínez-Chaparro B.
Introduction: The neurobiology of neuropathic pain is complex and is produce by injury in the central or peripheral nervous system. Mangiferin has been shown antioxidant properties that could be modulated a few molecular targets in this type of pain. The present study was undertaken to determinate the possible antiallodynic effect of mangiferin in neuropathic pain in rats, as well as the possible mechanisms of action of this compound. Methods: The rat was subjected to L5/L6 spinal nerve ligation (SNL) in order to induced allodynia. Further, allodynia was evaluated through up-down method. Results: The intrathecal administration of mangiferin prevented the mechanical allodynia induced by SNL, in a dose-dependent fashion. The antiallodynic effect induced by mangiferin was blocked by glibenclamide (50 µg/rat, a channel blocker of ATP-sensitive K+), methiothepin (30 µg/rat, a non-selective antagonist of 5-HT receptors), L-NAME (100 µg/rat, inhibitor nitric oxide synthase), ODQ (10 µg/rat, an inhibitor of guanylate-cyclase), SB-659551 (6 µg/rat, an selective antagonist of 5-HT5A receptor), but not by naloxone (50 µg/rat, a non-selective antagonist of opioids receptors). This data suggest that the antiallodynic effect induced by mangiferin is mediated by the serotoninergic system involving the activation of 5-HT5A receptor as well as the oxide nitric-cyclic GMP- K+ channel dependent of ATP pathway but not by the opioidergic system in a model of neuropathic pain in rats. Conclusions: Mangiferin may prove to be effective in treating neuropathic pain in humans.
Citation Format: Espinosa de los Monteros-Zuñiga A, Izquierdo-Sánchez T, Godínez-Chaparro B (2015) Antiallodynic effect of mangiferin in neuropathic pain. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S93. Abstract nr PPP-01.