J Pharm Pharmacogn Res 3(suppl. 1): S101, 2015
Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015 September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.
PPP-09: PHARMACOKINETICS AND RELATIVE BIOAVAILABILITY OF ZINC IONS RELEASED FROM A ZINC-ZEOLITIC (ZZ) MODIFIED RELEASE PRODUCT IN WISTAR RATS BY BOOTSTRAP
Acuña G1, del Toro H1, Rodríguez L1, de Castro N1, Rodríguez G2.
Introduction: Intestinal zinc absorption has a saturable component and proceeds over the entire intestinal length. Thus, administration of zinc in modified release drug products could increase zinc bioavailability if the release of non-saturating zinc concentrations in intestinal lumen over an extended period could be achieved. Researchers from the Institute of Science and Technology of Materials of the University of Havana developed a zinc-containing zeolitic product (ZZ) that can release zinc ions in a controlled manner in vitro by ionic interchange with the medium. The objectives of this work were to study the pharmacokinetics and to determine the relative bioavailability of Zn released from ZZ using ZnSO4, 7H2O as reference product. Material and Methods: After the intragastric administration of ZZ (15 mg Zn/kg) or ZnSO4, 7H2O (3.41 mg Zn/kg) to Wistar rats, blood samples were collected by one-point sampling. Serum Zn concentrations were determined by atomic absorption spectroscopy. Using random numbers and permitting replacements of the experimentally determined serum concentration values, 1000 pseudoprofiles were generated by bootstrap. For each pseudoprofile, pharmacokinetic parameters were determined by non-compartmental analysis. Results and Conclusions: The coefficient of variation calculated for each parameter after three replicates of the bootstrap algorithm was less than 1%, indicating that the procedure was sufficiently reliable. The half-lives of Zn released from both products were significantly different, suggesting a flip-flop type kinetic associated to ZZ. The absorption rates were very similar between both products suggesting the rapid release of an initial portion of the dose included in ZZ, followed by the controlled release of a maintenance dose. Zinc released from ZZ was 90% more bioavailable than zinc released from ZnSO4 7H2O.
Citation Format: Acuña G, del Toro H, Rodríguez L, de Castro N, Rodríguez G (2015) Pharmacokinetics and relative bioavailability of zinc ions released from a zinc-zeolitic (ZZ) modified release product in Wistar rats by bootstrap. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S101. Abstract nr PPP-09.