J Pharm Pharmacogn Res 3(suppl. 1): S105, 2015
Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015 September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.
PPP-13: ACUTE AND CHRONIC ANTI-INFLAMMATORY ACTIVITY OF THE Cucurbita moschata DUCH VEGETABLE OIL
Sueiro-Oyarzun ML1, Torres-Pla G1, Cabrera-Santos K2, Siverio-Mota D1, Jorge-Rodríguez ME1.
Introduction: The Cucurbita moschata seed oil is used for medicinal purposes. The anti-inflammatory effect of the Cucurbita species’ oil has not been scientifically proven. The objective was to evaluate the acute and chronic anti-inflammatory activity of C. moschata oil. Material and Methods: An experimental study was conducted at the Central University of Las Villas. Evaluation of acute anti-inflammatory activity of the oil (0.5, 1 and 2 mL/kg) was performed by plantar edema induced by histamine and serotonin and chronic anti-inflammatory activity was done using granuloma induced by cotton pellet model, both in Wistar rats. Results: The inflammation of the groups treated with oil induced by histamine and serotonin was lower than the negative control (sodium chloride). For histamine-induced edema, groups treated with oil showed similar percentages of inflammation to the positive control (cyproheptadine). For serotonin edema, groups treated with oil showed higher percentage of inflammation than the positive control (indomethacin). Chronic inflammation assay showed higher weight values for the wet content than for the dry content. The weight of the wet content was higher for the negative control (sodium chloride) and lower for those groups treated with oil. The negative control value reaches the highest weight of dry content and the lowest value is the dose of 2 mL/kg. The percentage of swelling of the wet and dry content were lowest at 2 mL/kg, for this group the highest inhibition of inflammation dry content was 78.15% and 66.17% for the wet content. Conclusions: The acute and chronic anti-inflammatory models evaluated showed an anti-inflammatory effect of Cucurbita moschata oil at doses of 0.5, 1 and 2 mL/kg with a possible dose-dependent behavior.
Citation Format: Sueiro-Oyarzun ML, Torres-Pla G, Cabrera-Santos K, Siverio-Mota D, Jorge-Rodríguez ME (2015) Acute and chronic anti-inflammatory activity of the Cucurbita moschata Duch vegetable oil. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S105. Abstract nr PPP-13.