J Pharm Pharmacogn Res 3(suppl. 1): S112, 2015
Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015 September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.
PPP-20: TOXICOLOGICAL AND PHARMACOLOGICAL EVALUATION OF A WATERY EXTRACT OF Pseudelephantopus spicatus ROOTS OR CAW´S TONGUE, CUBA
Hernández M1, Pizarro A2, García D1, Saucedo Y3, Armas Y3, Zaita Y1, Santos N1, Bauta R1, Artiles M1, Galbán M1.
Introduction: Fever generally accompanies the inflammatory and painful processes. Among their therapies, the tendency prevails to the use of the analgesic, antipyretics and anti-inflammatory non-steroidal drugs well-known as NAIDs. But the adverse reactions that NAIDs exhibits, makes necessary the search of new alternatives, finding in the traditional and natural medicine a novel exploration line. Pseudelephantopus spicatus is medicinal specie with tradition of antifebrile use by the Cuban people. However, the scientific literature do not refer any pharmacological study that endorse the usefulness off the plant as antipyretic, neither describe his toxicologist potential. An experimental preclinical study was carried out with the objective of evaluate from the pharmacological and toxicological point of view a watery extract obtained starting from the roots of Pseudelephantopus spicatus, well-known as caw´s tongue in Cuba. Methods: The toxic potential of the extract was determined in Sprague Dawley rats to unique dose for oral way, being not toxic when applying the Procedure of Fixed Dose, being its superior DL50 to 2000 mg/kg of weight. The antipyretic pharmacological activity of the watery extract of roots was evaluated using the chemical method in Wistar rats. The doses studied for oral way they were of 200, 400 and 800 mg/kg for the extract and the positive control was ibuprofen 100 mg/kg of weight. It was conformed a group control that received distilled water. All the groups consisted of six distributed animals in an aleatory way. Fever was induced by subcutaneous injection from a solution to brewer’s yeast (15 %) in chloride of sodium at 0.9%. The rectal temperature variable was valued at 1, 2 and 3 h after the treatment. Results and Conclusions: The results demonstrated effect antipyretic being the dose with more effectiveness was 400 mg/kg of weight for the used pattern.
Citation Format: Hernández M, Pizarro A, García D, Saucedo Y, Armas Y, Zaita Y, Santos N, Bauta R, Artiles M, Galbán M (2015) Toxicological and pharmacological evaluation of a watery extract of Pseudelephantopus spicatus roots or caw´s tongue, Cuba. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S112. Abstract nr PPP-20.