J Pharm Pharmacogn Res 3(suppl. 1): S114, 2015

Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015  September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.



Berenguer CA1, Landazuri S2, Puente E1, Rodríguez E1, Fong O1.

1Centro de Toxicología y Biomedicina (TOXIMED), Autopista Nacional Km 1 ½, Santiago de Cuba, Cuba. Teléfono: + (53)(22) 64-3796. E-mail: clara.berenguer@medired.scu.sld.cu
2Vice Dirección de Ciencia y Técnica, Universidad de Ciencias Médicas, Santiago de Cuba, Cuba.


Introduction: The neem tree (Azadirachta indica A. Juss) is a medicinal plant with an ancestral use and has been widely used in traditional medicine since it has a wide spectrum of medicinal properties, however, scientific research of its therapeutic properties are developed for some years. Therefore, in the following work we set as Objective: To determine the phytochemical composition and evaluate the anti-inflammatory activity of the hydroalcoholic extract of leaves and stems of the plant Azadirachta indica. Material and Methods: The hydroalcoholic extract was obtained using a Soxhlet apparatus, which was subjected to a preliminary phytochemical screening and characterized by UV/VIS spectroscopy. For assessing anti-inflammatory activity, we used the model of acute inflammation of the paw edema induced by 1% formalin in Sprague Dawley rats using ibuprofen as a positive control and three dose levels of each extract to thereby obtain the curve dose – response. Results: the presence of abundant flavonoids, phenols and tannins, saponins, followed by triterpenes, glucosides, saponins, alkaloids and carbohydrates was determined. Anti-inflammatory activity was evidenced by reducing edema in the model used at doses of 600 and 300 mg/kg when compared to the reference drug, it can be given by the combined action of different secondary metabolites present in the extract. Conclusions: The evaluated plant showed anti-inflammatory activity, thus justifying the traditional use that has had this plant by the population for the acute treatment of diseases with an inflammatory component.


Citation Format: Berenguer CA, Landazuri S, Puente E, Rodríguez E, Fong O (2015) Antiinflamatory activity of Azadirachta indica A. Juss. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S114. Abstract nr PPP-22.