Probable interaction between levothyroxine and Thymus vulgaris

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J. Pharm. Pharmacogn. Res., vol. 12, no. 6, pp. 1196-1198, Nov-Dec 2024. DOI: https://doi.org/10.56499/jppres24.2008_12.6.1196 Case Report Probable interaction between levothyroxine sodium and thyme (Thymus vulgaris), about a case report [Interacción probable entre levotiroxina sódica y tomillo (Thymus vulgaris), sobre un reporte de caso] Nassima Elyebdri1,2*, Sihem Baba Ahmed1, Nessrine Abourejal1, Lotfi Loudjedi3, Assia Bououden3, Nour … Continue reading Probable interaction between levothyroxine and Thymus vulgaris

J. Pharm. Pharmacogn. Res., vol. 12, no. 6, pp. 1196-1198, Nov-Dec 2024.

DOI: https://doi.org/10.56499/jppres24.2008_12.6.1196

Case Report

Probable interaction between levothyroxine sodium and thyme (Thymus vulgaris), about a case report

[Interacción probable entre levotiroxina sódica y tomillo (Thymus vulgaris), sobre un reporte de caso]

Nassima Elyebdri1,2*, Sihem Baba Ahmed1, Nessrine Abourejal1, Lotfi Loudjedi3, Assia Bououden3, Nour El Houda Khelil4

1Department of Pharmacy, Faculty of Medicine, Abou Bekr Belkaid University, Tlemcen, Algeria.

2Laboratory of Organic Chemistry Natural Substances and Analysis (C.O.S.N.A.), Abu Bekr Belkaid University, Tlemcen, Algeria.

3University Hospital Center, Tlemcen, Algeria.

4Department of Medicine, Faculty of Medicine, Abou Bekr Belkaid University, Tlemcen, Algeria.

*E-mail: nassima.elyebdri@univ-tlemcen.dz, nassimaelyebdri@gmail.com

Abstract

Thyme (Thymus vulgaris) is often used thanks to its anti-infectious properties to treat seasonal influenza. Some patients use it in conjunction with their conventional treatment, which can expose them to adverse effects or interactions. A case of probable pharmacokinetic interaction of levothyroxine and thyme is described. This is a case of 52-year-old woman admitted to the toxicology department in January 2024 after a phytovigilance questionnaire. The patient had a treatment for hypothyroidism consisting in levothyroxine sodium with a daily dose of 150 µg, but she showed palpitations following the taking of a T. vulgaris tea to treat her seasonal flu. She reported that the symptoms disappeared by reducing the doses of T. vulgaris. The score of the probability scale of the interaction was 6, so a probable interaction may occur in patients with thyroid disorders and taking levothyroxine sodium concomitantly with T. vulgaris.

Keywords: herbal-drug interaction; hypothyroidism; levothyroxine; thyme.

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Resumen

El tomillo (Thymus vulgaris) se utiliza a menudo gracias a sus propiedades antiinfecciosas para tratar la gripe estacional. Algunos pacientes lo utilizan junto con su tratamiento convencional, lo que puede exponerles a efectos adversos o interacciones. Se describe un caso de probable interacción farmacocinética de levotiroxina y tomillo. Se trata de una mujer de 52 años ingresada en el servicio de toxicología en enero de 2024 tras un cuestionario de fitovigilancia. La paciente tenía un tratamiento para el hipotiroidismo consistente en levotiroxina sódica con una dosis diaria de 150 µg, pero presentó palpitaciones tras la toma de una infusión de T. vulgaris para tratar su gripe estacional. Informó de que los síntomas desaparecieron al reducir las dosis de T. vulgaris. La puntuación de la escala de probabilidad de la interacción fue de 6, por lo que puede producirse una interacción probable en pacientes con trastornos tiroideos y que toman levotiroxina sódica concomitantemente con T. vulgaris.

Palabras Clave: hipotiroidismo; interacción hierba-fármaco; levotiroxina; tomillo.

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Citation Format: Elyebdri N, Baba Ahmed S, Abourejal N, Loudjedi L, Bououden A, Khelil NEH (2024) Probable interaction between levothyroxine sodium and thyme (Thymus vulgaris), about a case report. J Pharm Pharmacogn Res 12(6): 1196–1198. https://doi.org/10.56499/jppres24.2008_12.6.1196
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