J Pharm Pharmacogn Res 3(suppl. 1): S135, 2015
Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015 September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.
PTS-43: ASSESSMENT OF ACUTE AND SUBCHRONIC ORAL TOXICITY OF SEED OIL Carapa guianensis Aublet EXTRACT
Curveco D1, Arencibia D2, Rosario L3, Narciandi J3, Alonso A3, Crespo Y3, Vidal A4.
Introduction: The seed oil extract of Carapa guianensis has various biomedical applications as solar protector, anticancer, antioxidant and antigenotoxic. The aim of this work was determined toxic effects of oil extract orally administered to Sprague Dawley rats from both sexes. Methods: Oral acute toxicity (2 000 mg/kg) was investigated according to the Acute Toxic Class Method and the subchronic study, rats were treated with doses at 400, 1 000 and 2 000 mg/kg for 90 days. Results: No evidence of treatment-related toxicity was detected. Thus, clinical observations, body weight, food intake, haematological parameters, organ weight ratios and histopathological findings showed no significant differences between control and treated groups. However, 2000 mg/kg in subchronic study, only in male rats, evidenced smaller increment in liver weight and alanine aminotransferase (ALT). Conclusions: These studies showed no evidences related oral toxicity in the administration of Carapa guianensis oil extract. It is recommended hepatic toxicity studies to demonstrate the mechanism that leads to an increase in liver enzymes in the highest dose evaluated.
Citation Format: Curveco D, Arencibia D, Rosario L, Narciandi J, Alonso A, Crespo Y, Vidal A (2015) Assessment of acute and subchronic oral toxicity of seed oil Carapa guianensis Aublet extract. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S135. Abstract nr PTS-43.