J. Pharm. Pharmacogn. Res., vol. 11, no. 5, pp. 887-901, Sep-Oct 2023.
DOI: https://doi.org/10.56499/jppres23.1712_11.5.887
Review
Risk factors for oral cancer: Thematic trends and research agenda
[Factores de riesgo del cáncer oral: Tendencias temáticas y agenda de investigación]
Orlando Pérez-Delgado1, Pablo Alejandro Millones-Gómez2, Alejandro Valencia-Arias3*, David Yeret Rodríguez-Salazar4
1Laboratorio de Investigación en Ciencias de la Salud, Universidad Señor de Sipán, Chiclayo, 14000, Peru.
2Vicerrectoría de Investigación, Universidad Señor de Sipán, Chiclayo, 14000, Peru.
3School of Industrial Engineering, Faculty of Engineering, Architecture and Urbanism, Universidad Señor de Sipán, Chiclayo 14001, Peru.
4Facultad de Ciencias de la Salud, Universidad Señor de Sipán, Chiclayo, 14000, Peru.
*E-mail: valenciajho@crece.uss.edu.pe
Abstract
Context: Oral cancer is difficult to define due to several factors. It’s known as oral squamous cell carcinoma (OSCC) and is common in the head and neck. Geographic variations in the impact of OSCC highlight the need for research on risk factors and treatment trends.
Aims: To identify the main research trends of studies on oral cancer risk factors in the scientific literature in the Scopus database and Web of Science.
Methods: This was an exploratory study of the risk factors for oral cancer designed considering the eligibility criteria defined by the PRISMA-2020 international statement, that is, inclusion and exclusion.
Results: A total of 215 documents from Scopus and Web of Science were subjected to bibliometric analysis. The years 2020 and 2021 were the most productive, with 18 and 22 articles, respectively. The leading author in productivity and impact was Johnson N, the leading journal was Oral Oncology, followed by the International Journal of Cancer, and the main contributing countries were the United States, the United Kingdom and India. The main thematic cluster was composed of concepts such as Tobacco and Alcohol as the major risk factors; concepts such as Mortality or Head and Neck were positioned as emerging within the scientific literature.
Conclusions: The main risk factors, i.e., alcohol and tobacco consumption, are relevant in terms of mortality in the consumer population, which is why their role should be determined in future studies.
Keywords: malignancy neoplasms; mortality; mouth neoplasms; oral cancer; risk factors; tobacco.
Resumen
Contexto: El cáncer oral es difícil de definir debido a varios factores. Se conoce como carcinoma oral de células escamosas (CCEO) y es frecuente en la cabeza y el cuello. Las variaciones geográficas en el impacto del CCEO ponen de manifiesto la necesidad de investigar los factores de riesgo y las tendencias de tratamiento.
Objetivos: Identificar las principales tendencias de investigación de los estudios sobre los factores de riesgo del cáncer oral en la literatura científica de la base de datos Scopus y Web of Science.
Métodos: Se trató de un estudio exploratorio de los factores de riesgo de cáncer oral diseñado considerando los criterios de elegibilidad definidos por la declaración internacional PRISMA-2020, es decir, inclusión y exclusión.
Resultados: Un total de 215 documentos de Scopus y Web of Science fueron sometidos a análisis bibliométrico. Los años 2020 y 2021 fueron los más productivos, con 18 y 22 artículos, respectivamente. El autor líder en productividad e impacto fue Johnson N, la revista líder fue Oral Oncology, seguida de International Journal of Cancer, y los principales países contribuyentes fueron Estados Unidos, Reino Unido e India. El principal cluster temático estuvo compuesto por conceptos como Tabaco y Alcohol como principales factores de riesgo; conceptos como Mortalidad o Cabeza y Cuello se posicionaron como emergentes dentro de la literatura científica.
Conclusiones: Los principales factores de riesgo, es decir, el consumo de alcohol y tabaco, son relevantes en términos de mortalidad en la población consumidora, por lo que su papel debería determinarse en futuros estudios.
Palabras Clave: neoplasias malignas; mortalidad; neoplasias bucales; cáncer oral; factores de riesgo; tabaco.
Citation Format: Pérez-Delgado O, Millones-Gómez PA, Valencia-Arias A, Rodríguez-Salazar DY (2023) Risk factors for oral cancer: Thematic trends and research agenda. J Pharm Pharmacogn Res 11(5): 887–901. https://doi.org/10.56499/jppres23.1712_11.5.887
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