Review on acceptability and WTP for HIV vaccine

J. Pharm. Pharmacogn. Res., vol. 10, no. 4, pp. 748-767, July-August 2022.


Acceptability of and willingness to pay for human immunodeficiency virus vaccination: A systematic literature review

[Aceptabilidad y disposición a pagar por la vacunación contra el virus de la inmunodeficiencia humana: Una revisión sistemática de la literatura]

Tram N.T. Huyen1, Somying Pumtong1, Sermsiri Sangroongruangsri1, Luerat Anuratpanich1,2*

1Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.

2Department of Pharmacy, Division of Social and Administrative Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.



Context: Vaccines for the human immunodeficiency virus (HIV) have considerably improved public health in the last century. Important considerations, however, are that effective vaccination substantially depends on the acceptability of future vaccines and that monetary measurements of vaccine preference, as reflected by the willingness to pay (WTP), may help policymakers establish health capital priorities.

Aims: To systematically pool data on vaccine acceptability and WTP.

Methods: A systematic search was performed over five databases to identify eligible articles published from 2005 to 2020, and key terms were used in accordance with the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analyses. Two researchers independently assessed the articles, extracted relevant data, and drew numerical and descriptive summaries for result presentation via Excel.

Results: Out of 31 eligible studies, 28 and 3 reported on the acceptability of and WTP for HIV vaccination, respectively. Acceptability levels ranged from 2.94% to 93.10%, with the average being 60.16%, and WTP values fell between US$108 and US$671. The most prevalent themes were the characteristics of HIV vaccines (safety/side effects, efficacy, duration of protection, vaccine-induced seropositivity).

Conclusions: Overall, the review uncovered a lack of standardized, universal, and acceptable scales for determining acceptability and WTP. The evaluation provided a comprehensive and systematic summary of these matters along with useful information for policymakers on maximizing public health under limited resources.

Keywords: acceptability; HIV; immunization; systematic review; vaccination; willingness-to-pay.



Contexto: Las vacunas contra el virus de la inmunodeficiencia humana (VIH) han mejorado considerablemente la salud pública en el último siglo. Las consideraciones importantes, sin embargo, son que la vacunación efectiva depende sustancialmente de la aceptabilidad de las vacunas futuras y que las mediciones monetarias de la preferencia por la vacuna, reflejadas en la disposición a pagar (WTP), pueden ayudar a los formuladores de políticas a establecer prioridades de capital de salud.

Objetivos: Agrupar sistemáticamente los datos sobre la aceptabilidad de las vacunas y la disposición a pagar.

Métodos: Se realizó una búsqueda sistemática en cinco bases de datos para identificar artículos elegibles publicados entre 2005 y 2020, y se utilizaron términos clave de acuerdo con las pautas de Preferred Reporting Items for Systematic Review and Meta-Analyses. Dos investigadores evaluaron de forma independiente los artículos, extrajeron datos relevantes y elaboraron resúmenes numéricos y descriptivos para la presentación de resultados a través de Excel.

Resultados: De los 31 estudios elegibles, 28 y 3 informaron sobre la aceptabilidad y la disposición a pagar por la vacunación contra el VIH, respectivamente. Los niveles de aceptabilidad oscilaron entre 2,94 % y 93,10 %, con un promedio de 60,16 %, y los valores de disposición a pagar estuvieron entre US$ 108 y US$ 671. Los temas más predominantes fueron las características de las vacunas contra el VIH (seguridad/efectos secundarios, eficacia, duración de la protección, seropositividad inducida por la vacuna).

Conclusiones: En general, la revisión descubrió la falta de escalas estandarizadas, universales y aceptables para determinar la aceptabilidad y la disposición a pagar. La evaluación brindó un resumen completo y sistemático de estos asuntos junto con información útil para los formuladores de políticas sobre cómo maximizar la salud pública con recursos limitados.

Palabras Clave: aceptabilidad; inmunización; revisión sistemática; vacunación; VIH; voluntad de pago.


Citation Format: Huyen TNT, Pumtong S, Sanroongruangsri S, Anuratpanich L (2022) Acceptability of and willingness to pay for human immunodeficiency virus vaccination: A systematic literature review. J Pharm Pharmacogn Res 10(4): 748–767.

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