J. Pharm. Pharmacogn. Res., vol. 12, no. 3, pp. 557-572, May-Jun 2024.

DOI: https://doi.org/10.56499/jppres23.1687_12.3.557

Review

Stem cell research in Indonesia from 2003 to 2022: A bibliometrics analysis

[Investigación con células madre en Indonesia de 2003 a 2022: Un análisis bibliométrico]

Imam Rosadi1*, Karina Karina2,3,4, Pitra Ariesta Sinta Dewi5,6, Anggraini Barlian7, Thania Fathimah Az Zahra1, Viol Dhea Kharisma8,9, Arif Nur Muhammad Ansori10,11

1Department of Biology, Faculty of Mathematics and Natural Sciences, Mulawarman University, Samarinda, Indonesia.

2Hayandra Clinic, Hayandra Peduli Foundation, Jakarta, Indonesia.

3Hayandra Lab, Hayandra Peduli Foundation, Jakarta, Indonesia.

4Research Center for Regenerative Medicine and Neuroscience, Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia.

5Metropolitan Medical Centre Hospital, Jakarta, Indonesia.

6SILC Lasik Centre, Jakarta, Indonesia.

7School of Life Sciences and Technology, Bandung Institute of Technology, Bandung, West Java, Indonesia.

8Division of Research and Development, CV Jalan Tengah, Surabaya, Indonesia.

9Department of Biology, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.

10Postgraduate School, Universitas Airlangga, Surabaya, Indonesia.

11Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India.

*E-mail: imamrosadi@unmul.ac.id

Abstract

Context: Stem cell research has become popular in Indonesia for more than a decade. The scope of research involves in vitro to animal studies as well as human trials. However, no evidence proved its trend.

Aims: To analyze the trends and patterns of stem cell research in Indonesia from 2003 to 2022 using a bibliometric analysis of the Scopus database.

Methods: The data for the paper were retrieved from Scopus and then analyzed using bibliometrics. Statistical data analysis was performed.

Results: The results showed that stem cell research in Indonesia has been increasing steadily over the years, with the majority of publications focusing on “Medicine”, “Biochemistry, Genetics, and Molecular Biology” and “Pharmacology, Toxicology, and Pharmaceutics”. It was found that a total of 260 related articles had been published. Rantam was identified as the most productive author, and the authorship network analysis identified nine clusters of authors. The keywords “stem cells”, “culture”, “proliferation”, “differentiation”, and “tissue engineering” were the most frequently used in the publications analyzed.

Conclusions: Overall, this study provides valuable insights into the development of stem cell research in Indonesia and may inform future research and funding decisions in this field.

Keywords: authorship; bibliometrics; biopharmaceutics; stem cell research; Indonesia.

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Resumen

Contexto: La investigación con células madre se ha popularizado en Indonesia desde hace más de una década. El ámbito de la investigación abarca desde estudios in vitro hasta estudios con animales, así como ensayos con humanos. Sin embargo, no hay pruebas que demuestren su tendencia.

Objetivos: Analizar las tendencias y patrones de la investigación con células madre en Indonesia desde 2003 hasta 2022 utilizando un análisis bibliométrico de la base de datos Scopus.

Métodos: Los datos para el artículo fueron recuperados de Scopus y luego analizados por la bibliométrica. Se realizó un análisis estadístico de los datos.

Resultados: Los resultados mostraron que la investigación con células madre en Indonesia ha ido aumentando constantemente a lo largo de los años, con la mayoría de las publicaciones centradas en "Medicina", "Bioquímica, Genética y Biología Molecular" y "Farmacología, Toxicología y Farmacéutica". En total se publicaron 260 artículos relacionados. Rantam fue identificado como el autor más productivo, y el análisis de la red de autoría identificó nueve grupos de autores. Las palabras clave "stem cells", "culture", "proliferation", "differentiation" y "tissue engineering" fueron las más utilizadas en las publicaciones analizadas.

Conclusiones: En general, este estudio proporciona información valiosa sobre el desarrollo de la investigación con células madre en Indonesia y puede servir de base para futuras investigaciones y decisiones de financiación en este campo.

Palabras Clave: autoría; bibliometría; biofarmacia; células madre investigación; Indonesia.

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Citation Format: Rosadi I, Karina K, Dewi PAS, Az Zahra TF, Barlian A, Kharisma VD, Ansori ANM (2024) Stem cell research in Indonesia from 2003 to 2022: A bibliometrics analysis. J Pharm Pharmacogn Res 12(3): 557–572. https://doi.org/10.56499/jppres23.1687_12.3.557
References

Berebichez-Fridman R, Gómez-García R, Granados-Montiel J, Berebichez-Fastlicht E, Olivos-Meza A, Granados J, Velasquillo C, Ibarra C (2017) The holy grail of orthopedic surgery: Mesenchymal stem cells - Their current uses and potential applications. Stem Cells Int 2017: 2638305. https://doi.org/10.1155/2017/2638305

Blick T, Hugo H, Widodo E, Waltham M, Pinto C, Mani SA, Weinberg RA, Neve RM, Lenburg ME, Thompson W (2010) Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44HI/CD24lO/-stem cell phenotype in human breast cancer. J Mammary Gland Biol Neoplasia 15(2): 235–252. https://doi.org/10.1007/S10911-010-9175-Z

Brovkina O, Dashinimaev E (2020) Advances and complications of regenerative medicine in diabetes therapy. PeerJ 8: e9746. https://doi.org/10.7717/PEERJ.9746

Dilogo IH, Aditianingsih D, Sugiarto A, Burhan E, Damayanti T, Sitompul PA, Mariana N, Antarianto RD, Liem IK, Kispa T, Mujadid F, Novialdi N, Luviah E, Kurniawati T, Lubis AMT, Rahmatika D (2021) Umbilical cord mesenchymal stromal cells as critical COVID-19 adjuvant therapy: A randomized controlled trial. Stem Cells Transl Med 10(9): 1279–1287. https://doi.org/10.1002/SCTM.21-0046

Dilogo IH, Mujadid F, Nurhayati RW, Kurniawan A (2018) Evaluation of bone marrow-derived mesenchymal stem cell quality from patients with congenital pseudoarthrosis of the tibia. J Orthop Surg Res 13: 266. https://doi.org/10.1186/S13018-018-0977-9

Fibrini D, Nyoman I, Lister E, Rosadi I (2022) Autologous platelet-rich plasma in the management of diabetic foot ulcer: A systematic review of randomized controlled trials. J Skin Stem Cell 9(2): e126907. https://doi.org/10.5812/JSSC-126907

Hariyadi DM, Islam N (2020) Current status of alginate in drug delivery. Adv Pharmacol Pharm Sci 2020: 8886095. https://doi.org/10.1155/2020/8886095

Hoffmeyer B, Fonnes S, Andresen, Kristoffer, Rosenberg, Jacob, Andresen K, Rosenberg J, Dk JR (2023) Use of inactive Cochrane reviews in academia: A citation analysis. Scientometrics 128: 2923–2934. https://doi.org/10.1007/S11192-023-04691-9

Hou D, Bi X, Mao Z, Fan Y, Hu X, Li X (2019) Biomaterials research of China from 2013 to 2017 based on bibliometrics and visualization analysis. PeerJ 7: e6859. https://doi.org/10.7717/peerj.6859

Kamal AF, Iskandriati D, Dilogo IH, Siregar NC, Hutagalung EU, Susworo R, Yusuf AA, Bachtiar A (2013) Biocompatibility of various hydoxyapatite scaffolds evaluated by proliferation of rat’s bone marrow mesenchymal stem cells. Med J Indones 22(4): 202–208. https://doi.org/10.13181/MJI.V22I4.600

Karina K, Christoffel LM, Novariani R, Rosadi I, Rosliana I, Rosidah S, Sobariah S, Fatkhurohman N, Puspitaningrum N, Hertati Y, Afini I, Ernanda D, Widyastuti T, Sulaeha AD, Zakiyah A, Aini N, Krisandi G, Andrew H (2021a) The effect of intravenous autologous activated platelet-rich plasma therapy on “profibrotic cytokine” IL-1 β levels in severe and critical COVID-19 patients: A preliminary study. Scientifica 2021: 9427978. https://doi.org/10.1155/2021/9427978

Karina K, Rosliana I, Rosadi I, Sobariah S, Christoffel LM, Novariani R, Rosidah S, Fatkhurohman N, Hertati Y, Puspitaningrum N, Subroto WR, Afini I, Ernanda D (2021b) Phase I/II clinical trial of autologous activated platelet-rich plasma (aaPRP) in the treatment of severe coronavirus disease 2019 (COVID-19) patients. Int J Inflamm 2021: 5531873. https://doi.org/10.1155/2021/5531873

Karina, Pawitan JA, Rosadi I (2020) Adipose-derived stem cells and their microenvironment (niche) in type 2 diabetes mellitus. Stem Cell Investig 7: 2. https://doi.org/10.21037/SCI.2019.12.02

Karina, Samudra MF, Rosadi I, Afini I, Widyastuti T, Sobariah S, Remelia M, Puspitasari RL, Rosliana I, Tunggadewi TI (2019) Combination of the stromal vascular fraction and platelet-rich plasma accelerates the wound healing process: Pre-clinical study in a Sprague-Dawley rat model. Stem Cell Investig 6: 18. https://doi.org/10.21037/SCI.2019.06.08

King NMP, Perrin J (2014) Ethical issues in stem cell research and therapy. Stem Cell Res Ther 5: 85. https://doi.org/10.1186/SCRT474

Kwon SG, Kwon YW, Lee TW, Park GT, Kim JH (2018) Recent advances in stem cell therapeutics and tissue engineering strategies. Biomater Res 22: 36. https://doi.org/10.1186/S40824-018-0148-4

Liras A (2010) Future research and therapeutic applications of human stem cells: General, regulatory, and bioethical aspects. J Transl Med 8: 131. https://doi.org/10.1186/1479-5876-8-131

Meiliana A, Dewi NM, Wijaya A (2016) Stem cell therapy in wound healing and tissue regeneration. The Indones Biomed J 8(2): 61–70. https://doi.org/10.18585/INABJ.V8I2.191

Omole AE, Fakoya AOJ (2018) Ten years of progress and promise of induced pluripotent stem cells: Historical origins, characteristics, mechanisms, limitations, and potential applications. PeerJ 6: e4370. https://doi.org/10.7717/PEERJ.4370

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM., Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hróbjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, Moher D (2021) The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ 372: n71. https://doi.org/10.1136/bmj.n71

Pawitan JA, Kispa T, Mediana D, Goei N, Fasha I, Liem IK, Wulandari D (2015) Simple production method of umbilical cord derived mesenchymal stem cell using xeno-free materials for translational research. J Chem Pharm Res 7(8): 652–656.

Phedy P, Djaja YP, Gatam L, Kusnadi Y, Wirawan RP, Tobing IMS, Subakir N, Mappulilu A., Prawira MA, Yauwenas R, Gatam AR (2019) Motoric recovery after transplantation of bone marrow derived mesenchymal stem cells in chronic spinal cord injury: A case report. Am J Case Rep 20: 1299–1304. https://doi.org/10.12659/AJCR.917624

Putra A, Ridwan FB, Putridewi AI, Kustiyah AR, Wirastuti K, Sadyah AC, Rosdiana I, Munir D (2018) The role of TNF-α induced MSCs on suppressive inflammation by increasing TGF-β and IL-10. Open Access Maced J Med Sci 6(10): 1779–1783. https://doi.org/10.3889/oamjms.2018.404

Rajabzadeh N, Fathi E, Farahzadi R (2019) Stem cell-based regenerative medicine. Stem Cell Investig 6: 18. https://doi.org/10.21037/SCI.2019.06.04

Rosadi I, Karina K, Kharisma VD, Ansori ANM (2021) L-ascorbic acid-2-phosphate and fibrin substrate enhances the chondrogenic differentiation of human adipose-derived stem cells. Prog Stem Cell 8(2): 310–317. https://doi.org/10.15419/psc.v8i2.412

Rosadi I, Karina K, Rosliana I, Sobariah S, Afini I, Widyastuti T, Barlian A (2019) In vitro study of cartilage tissue engineering using human adipose-derived stem cells induced by platelet-rich plasma and cultured on silk fibroin scaffold. Stem Cell Res Ther 10: 369. https://doi.org/10.1186/S13287-019-1443-2

Rosadi I, Indrady FT, Karina K, Hariani N (2022) Evaluation effects of ascorbic acid leads to activate and induce osteogenic protein marker expression: in silico and in-vitro study. Biomed Res Ther 9(1): 4832–4841. https://doi.org/10.15419/bmrat.v9i1.720

Sibuea CV, Pawitan JA, Antarianto R, Jasirwan COM, Sianipar IR, Luviah E, Nurhayati RW, Mubarok W, Mazfufah NF (2020) 3D co-culture of hepatocyte, a hepatic stellate cell line, and stem cells for developing a bioartificial liver prototype. Int J Technol 11(5): 951–962. https://doi.org/10.14716/IJTECH.V11I5.4317

van Eck NJ, Waltman L (2009) Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics 84(2): 523–538. https://doi.org/10.1007/S11192-009-0146-3

Wahyuningsih KA, Karina K, Rosadi I, Rosliana I, Subroto WR (2020) Effect of ascorbic acid on morphology of post-thawed human adipose-derived stem cells. Stem Cell Investig 7: 16. https://doi.org/10.21037/SCI-2020-011

Wan R, Li L, Xing C, Peng R, Gao L (2019) Worldwide scientific productions with immunotherapy of sepsis: A bibliometric analysis. PeerJ 7: e7116. https://doi.org/10.7717/peerj.7116

Widowati W, Wijaya L, Bachtiar I, Gunanegara RF, Sugeng SU, Irawan YA, Sumitro SB, Widodo, MA (2014) Effect of oxygen tension on proliferation and characteristics of Wharton’s jelly-derived mesenchymal stem cells. Biomarkers Genomic Med 6(1): 43–48. https://doi.org/10.1016/J.BGM.2014.02.001

Yessentayeva SY, Orakbay LZ, Adilhanova A, Yessimov N (2022) Approaches to the use of stem cells in regenerative medicine. Anal Biochem 645: 114608. https://doi.org/10.1016/J.AB.2022.114608

Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, Benhaim P, Lorenz HP, Hedrick MH (2004) Multilineage cells from human adipose tissue: Implications for cell-based therapies. Tissue Eng 7(2): 211–228. https://doi.org/10.1089/107632701300062859

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