Tag Archives: monosodium glutamate

Toxic effects of monosodium glutamate on ovary in rats

J. Pharm. Pharmacogn. Res., vol. 10, no. 3, pp. 397-405, May-June 2022.

Original Article

The ovulation assessment of regular cyclic rats following subacute oral administration of monosodium glutamate: An in vivo study

[Evaluación de la ovulación en ratas con ciclos regulares después de la administración oral subaguda de glutamato monosódico: Un estudio in vivo]

Mahfoudh Almusli Mohammed Abdulghani

Department of Pharmacology & Toxicology, Unaizah College of Pharmacy, Qassim University, Unaizah, 51911, Al Qassim, Saudi Arabia.

*E-mail: ma.abdulghani@qu.edu.sa, mahfouz08@gmail.com


Context: The possible toxic effects of monosodium glutamate (MSG) on ovarian functions have not been thoroughly evaluated in contrast to testicular functions. Few studies documented that MSG showed histological alterations.

Aims: To investigate the subacute effects of oral MSG (2 g/kg) on estrogen level and numbers of ovulated oocytes and histological changes in ovary of Sprague-Dawley (SD) rats.

Methods: Virgin young adult SD female rats with a regular estrous cycle were randomly assigned to either MSG-treated group or control group, and the duration of treatment was 14-16 days for oral administration MSG or vehicle (distilled water), respectively.

Results: Oral MSG treatment with doses of 2 g/kg/day showed significantly (p<0.01) reduced numbers of ovulated oocytes in the oviduct, newly formed corpora lutea, large follicles in histology of ovarian sections and attenuated serum estrogen levels.

Conclusions: Subacute oral administration of MSG may negatively influence the ovarian function of young female rats via reduction of ovulated oocytes and the attenuation of estrogen level.

Keywords: corpora lutea; estrogen level; follicles ovarian; monosodium glutamate; oocytes; ovulation; toxicity.


Contexto: Los posibles efectos tóxicos del glutamato monosódico (MSG) en las funciones ováricas no se han evaluado a fondo en contraste con las funciones testiculares. Pocos estudios documentaron que el GMS mostrara alteraciones histológicas.

Objetivos: Investigar los efectos subagudos del glutamato monosódico oral (2 g/kg) sobre el nivel de estrógeno y el número de ovocitos ovulados y los cambios histológicos en el ovario de ratas Sprague-Dawley (SD).

Métodos: Se asignaron al azar ratas SD hembra adultas jóvenes vírgenes con un ciclo estral regular al grupo tratado con MSG o al grupo de control, y la duración del tratamiento fue de 14 a 16 días para la administración oral de MSG o vehículo (agua destilada), respectivamente.

Resultados: El tratamiento con MSG oral con dosis de 2 g/kg/día mostró un número significativamente reducido (p<0,01) de ovocitos ovulados en el oviducto, cuerpos lúteos recién formados, folículos grandes en la histología de las secciones ováricas y niveles atenuados de estrógeno sérico.

Conclusiones: La administración oral subaguda de MSG puede influir negativamente en la función ovárica de ratas hembra jóvenes a través de la reducción de los ovocitos ovulados y la atenuación del nivel de estrógeno.

Palabras Clave: cuerpos lúteos; folículos ováricos; glutamato monosódico; nivel de estrógeno; ovocitos; ovulación; toxicidad.

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Citation Format: Abdulghani MAM (2022) The ovulation assessment of regular cyclic rats following subacute oral administration of monosodium glutamate: An in vivo study. J Pharm Pharmacogn Res 10(3): 397–405.

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