Terminalia chebula protected the doxorubicin-induced renal damage

Excerpt:


J Pharm Pharmacogn Res 8(3): 237-246, 2020. DOI: https://doi.org/10.56499/jppres19.773_8.3.237 Original Article The activity of Terminalia chebula Retz. extract on doxorubicin-induced renal damage in rats [La actividad del extracto de Terminalia chebula Retz. sobre el daño renal inducido por doxorrubicina en ratas] Aamina Muneer1, Ahmad Alhowail2, Maha Aldubayan2, Syed Imam Rabbani1,2 1Department of Pharmacology, Al-Ameen College of Pharmacy, … Continue reading Terminalia chebula protected the doxorubicin-induced renal damage

J Pharm Pharmacogn Res 8(3): 237-246, 2020.

DOI: https://doi.org/10.56499/jppres19.773_8.3.237

Original Article

The activity of Terminalia chebula Retz. extract on doxorubicin-induced renal damage in rats

[La actividad del extracto de Terminalia chebula Retz. sobre el daño renal inducido por doxorrubicina en ratas]

Aamina Muneer1, Ahmad Alhowail2, Maha Aldubayan2, Syed Imam Rabbani1,2

1Department of Pharmacology, Al-Ameen College of Pharmacy, Bangalore, India.
2Department of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah, Kingdom of Saudi Arabia.
Abstract

Context: Doxorubicin (DXR) is a common anticancer drug known to produce several complications. Terminalia chebula popularly known as ‘King of medicine’ is found to possess wound healing, anti-inflammatory and antioxidant properties.

Aims: To evaluate the effects of Terminalia chebula extract on doxorubicin-induced renal damages in rats.

Methods: Coadministration of Terminalia chebula extract (0.25, 0.5 and 1.0 g/kg) was tested against DXR (2.5 mg/kg) induced renal damages in rats. Additional two groups were evaluated by administering 0.5 g/kg of the extract to animals either before or after DXR treatment. Kidney function tests were performed by measuring the serum levels of urea, creatinine, uric acid, and total protein. The antioxidant activity of the extract was evaluated by in vivo and in vitro methods. Histopathology of kidney tissues was performed to assess the morphological changes. The significance of results obtained were statistically analyzed.

Results: The data obtained indicated that co-administration of the extract at higher doses (0.5 and 1.0 g/kg) significantly (p<0.01) reduces the serum levels of creatinine, urea, uric acid, and total proteins compared to DXR group. The extract also decreases the structural damages induced by DXR and exhibited antioxidant property. However, the pre- and post-treatments of Terminalia extract neither alter significantly the biomarker levels nor ameliorated the histopathological changes induced by DXR in rats.

Conclusions: The observations indicated that co-administration of Terminalia chebula decreased the renal damage induced by DXR in rats. The protective action of the extract may be related to its wound-healing and antioxidant properties, the latter of which diminished the free-radical damage induced by DXR.

Keywords: antioxidant; doxorubicin; renal damage; Terminalia chebula.

Resumen

Contexto: La doxorrubicina (DXR) es un medicamento común contra el cáncer que produce varias complicaciones. La Terminalia chebula, conocida popularmente como "Rey de la medicina", posee propiedades curativas, anti-inflamatorias y antioxidantes.

Objetivos: Evaluar los efectos del extracto de Terminalia chebula sobre daños renales inducidos por doxorrubicina en ratas.

Métodos: La administración conjunta del extracto de Terminalia chebula (0,25; 0,5 y 1,0 g/kg) se probó contra daños renales inducidos por DXR (2.5 mg/kg) en ratas. Se evaluaron dos grupos adicionales administrando 0,5 g/kg del extracto a animales antes o después del tratamiento con DXR. Las pruebas de función renal se realizaron midiendo los niveles séricos de urea, creatinina, ácido úrico y proteína total. La actividad antioxidante del extracto se evaluó por métodos in vivo e in vitro. La histopatología de los tejidos renales se realizó para evaluar los cambios morfológicos. La importancia de los resultados obtenidos se analizó estadísticamente.

Resultados: La administración conjunta del extracto a dosis más altas (0,5 y 1,0 g/kg) significativamente (p <0,01) redujo los niveles séricos de creatinina, urea, ácido úrico y proteínas totales en comparación con el grupo DXR. El extracto también disminuyó los daños estructurales inducidos por DXR y exhibió propiedades antioxidantes. Sin embargo, los tratamientos previos y posteriores del extracto de Terminalia no alteraron significativamente los niveles de biomarcadores ni mejoraron los cambios histopatológicos inducidos por DXR en ratas.

Conclusiones: Las observaciones indicaron que la administración conjunta de Terminalia chebula disminuyó el daño renal inducido por DXR en ratas. La acción protectora del extracto puede estar relacionada con sus propiedades antioxidantes y de curación de heridas, la última de las cuales disminuyó el daño de los radicales libres inducido por DXR.

Palabras Clave: antioxidante; daño renal; doxorrubicina; Terminalia chebula.

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Citation Format: Muneer A, Alhowail A, Aldubayan M, Rabbani SI (2020) The activity of Terminalia chebula Retz. extract on doxorubicin-induced renal damage in rats. J Pharm Pharmacogn Res 8(3): 237–246. DOI: https://doi.org/10.56499/jppres19.773_8.3.237

© 2020 Journal of Pharmacy & Pharmacognosy Research (JPPRes)

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