Therapeutic use of E. aureum in Parkinson’s disease

Excerpt:


J Pharm Pharmacogn Res 8(3): 225-236, 2020. Original Article Ethanol extract of Epipremnum aureum leaves attenuate intranigral-rotenone induced Parkinson’s disease in rats [El extracto etanólico de hojas de Epipremnum aureum atenúa la enfermedad de Parkinson inducida por rotenona intranigral en ratas] Suraj Sood1, Manish Kumar1,2, Nitin Bansal1* 1Department of Pharmacology, ASBASJSM College of Pharmacy, Bela (Ropar), Punjab-140111, … Continue reading Therapeutic use of E. aureum in Parkinson’s disease

J Pharm Pharmacogn Res 8(3): 225-236, 2020.

Original Article

Ethanol extract of Epipremnum aureum leaves attenuate intranigral-rotenone induced Parkinson’s disease in rats

[El extracto etanólico de hojas de Epipremnum aureum atenúa la enfermedad de Parkinson inducida por rotenona intranigral en ratas]

Suraj Sood1, Manish Kumar1,2, Nitin Bansal1*

1Department of Pharmacology, ASBASJSM College of Pharmacy, Bela (Ropar), Punjab-140111, India.
2I. K. Gujral Punjab Technical University, Kapurthala, Punjab-144603, India.
Abstract

Context: Parkinson’s disease (PD) is characterized by motor-symptoms attributed to profound (60 – 70%) neurodegeneration in the striatum and loss of dopamine thereof. Oxidative stress, mitochondrial dysfunction and neuroinflammation are major contributors to neurodegenerative pathogenesis of PD. Epipremnum aureum is an ornamental plant found to possess significant antioxidant and anti-inflammatory properties.

Aims: To evaluate the neuroprotective potential of ethanol extract of E. aureum (EEA) leaves against rotenone-induced neurotoxicity in rats.

Methods: Stereotaxic brain surgery was performed on day 1 and rotenone (ROT) was injected (300 µg/µL) in the substantia nigra pars compacta (SNpc) to induce PD in rats. EEA (125, 250 and 500 mg/kg, p.o.) was administered to ROT-treated rats for 28 consecutive days. Rearing behavior, ambulation, catalepsy and paw retraction test were performed on day 28. After behavioral tests, rats were sacrificed, whole-brain removed and TBARS, GSH and catalase activity was determined in brain homogenate.

Results: ROT-treated rats showed a conspicuous increase in the catatonic score, paw retraction time and decline in the ambulatory score and rearing score that exhibited induction of PD in rats. The motor-symptoms triggered by rotenone were significantly reversed in EEA (250 and 500 mg/kg) treated animals. EEA treatment significantly attenuated the intranigral ROT induced rise in brain TBARS and a decline in GSH content and catalase activity.

Conclusions: The study demonstrated that in the present model of PD, treatment with EEA mitigates the key symptoms (e.g. hypokinesia, rigidity and postural instability) through potent antioxidant activity.

Keywords: catalepsy; Epipremnum aureum; oxidative stress; Parkinson’s disease; rotenone; substantia nigra pars compacta.

Resumen

Contexto: La enfermedad de Parkinson (EP) se caracteriza por síntomas motores atribuidos a una neurodegeneración profunda (60-70%) en el cuerpo estriado y la pérdida de dopamina del mismo. El estrés oxidativo, la disfunción mitocondrial y la neuroinflamación son los principales contribuyentes a la patogénesis neurodegenerativa de la EP. Epipremnum aureum es una planta ornamental que posee propiedades antioxidantes y anti-inflamatorias significativas.

Objetivos: Evaluar el potencial neuroprotector del extracto etanólico de E. aureum (EEA) contra la neurotoxicidad inducida por rotenona en ratas.

Métodos: La cirugía cerebral estereotáxica se realizó el día 1 y se inyectó rotenona (ROT) (300 µg/µL) en sustancia negra compacta (SNpc) para inducir la EP en ratas. Se administró EEA (125, 250 y 500 mg/kg, p.o.) a ratas tratadas con ROT durante 28 días consecutivos. La prueba de comportamiento de crianza, la deambulación, la catalepsia y la retracción de la pata se realizaron el día 28. Después de las pruebas de comportamiento, se sacrificaron las ratas, se extrajo todo el cerebro y se determinó la actividad de TBARS, GSH y catalasa en homogeneizado de cerebro.

Resultados: Las ratas tratadas con ROT mostraron un notable aumento en la puntuación catatónica, el tiempo de retracción de la pata y la disminución en la puntuación ambulatoria y la puntuación de crianza que exhibieron inducción de EP en ratas. Los síntomas motores desencadenados por la rotenona se revirtieron significativamente en los animales tratados con EEA (250 y 500 mg/kg). El tratamiento con EEE atenuó significativamente el aumento inducido por ROT intranigral en los TBARS cerebrales y la disminución en el contenido de GSH y la actividad de catalasa.

Conclusiones: El estudio demostró que, en el presente modelo de EP, el tratamiento con EEA mitiga los síntomas clave (por ejemplo, hipocinesia, rigidez e inestabilidad postural) a través de una potente actividad antioxidante.

Palabras Clave: catalepsia; Epipremnum aureum; estrés oxidativo; enfermedad de Parkinson; rotenona; sustancia nigra pars compacta.

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Citation Format: Sood S, Kumar M, Bansal N (2020) Ethanol extract of Epipremnum aureum leaves attenuate intranigral-rotenone induced Parkinson’s disease in rats. J Pharm Pharmacogn Res 8(3): 225–236.

© 2020 Journal of Pharmacy & Pharmacognosy Research (JPPRes)

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