Toxicity of sibutramine-adulterated supplements

Excerpt:


J. Pharm. Pharmacogn. Res., vol. 12, no. 2, pp. 363-370, Mar-Apr 2024. DOI: https://doi.org/10.56499/jppres23.1852_12.2.363 Original Article Toxicity of sibutramine hydrochloride-adulterated weight loss supplements in rats based on biochemical and organ weight parameters [Toxicidad de los suplementos de pérdida de peso adulterados con clorhidrato de sibutramina en ratas según parámetros bioquímicos y de peso de órganos] … Continue reading Toxicity of sibutramine-adulterated supplements

J. Pharm. Pharmacogn. Res., vol. 12, no. 2, pp. 363-370, Mar-Apr 2024.

DOI: https://doi.org/10.56499/jppres23.1852_12.2.363

Original Article

Toxicity of sibutramine hydrochloride-adulterated weight loss supplements in rats based on biochemical and organ weight parameters

[Toxicidad de los suplementos de pérdida de peso adulterados con clorhidrato de sibutramina en ratas según parámetros bioquímicos y de peso de órganos]

Suparmi Suparmi1*, Suryani Yuliyanti2, Hesti W. Karyadini3, Andi M.R. Syamsudin4, Edil Kurniawan Gau4

1Department of Biology, Faculty of Medicine, Universitas  Islam Sultan Agung,  Semarang, 50112, Indonesia.

2Department of Public Health, Faculty of Medicine, Universitas Islam Sultan Agung Semarang, 50112, Indonesia.

3Department of Dermatology and  Venereology Faculty of Medicine, Universitas Islam Sultan Agung Semarang, 50112, Indonesia.

4Study Program of Medical Education, Faculty of Medicine, Universitas Islam Sultan Agung Semarang, 50112, Indonesia.

*E-mail: suparmi@unissula.ac.id

Abstract

Context: Weight-loss supplements are typically natural or herbal supplements that promote weight loss and enhance health. However, the increase in consumption results in the fraudulent adulteration of conventional pharmaceutical drugs, such as sibutramine hydrochloride (SHCl).

Aims: To determine the toxicity of weight loss supplements adulterated with SHCl in rats.

Methods: Five samples (J1–J5) of weight loss supplements adulterated with SHCl were collected from an online market. The toxicity of the samples was evaluated using 42 male Wistar rats for 35 days. The rats were divided into seven groups: control, J1, J2, J3, J4, J5, and SHCl.

Results: The J1 supplement resulted in the most rapid weight loss in rats compared to the other supplements tested. The kidney and liver weights of rats administered weight loss supplements adulterated with SHCl were greater than those of control rats. J1 indicated the supplement with the highest level of toxicity. The group administered J1 exhibited the highest levels of toxicity across all evaluated parameters.

Conclusions: This study confirmed the toxicity of weight loss supplements adulterated with SHCl in rats, contributing to the understanding and treatment of adulterated weight loss supplements. Dietary supplements for weight loss should be thoroughly screened for undeclared sibutramine hydrochloride adulteration to protect public health and strengthen legal provisions.

Keywords: adulteration; hepatotoxicity; kidney toxicity; sibutramine hydrochloride; weight loss supplements.

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Resumen

Contexto: Los suplementos para adelgazar suelen ser complementos naturales o a base de hierbas que favorecen la pérdida de peso y mejoran la salud. Sin embargo, el aumento de su consumo provoca la adulteración fraudulenta de fármacos convencionales, como el clorhidrato de sibutramina (SHCl).

Objetivos: Determinar la toxicidad de los suplementos para adelgazar adulterados con SHCl en ratas.

Métodos: Se recogieron cinco muestras (J1-J5) de suplementos para adelgazar adulterados con SHCl en un mercado online. La toxicidad de las muestras se evaluó con 42 ratas Wistar macho durante 35 días. Las ratas se dividieron en siete grupos: control, J1, J2, J3, J4, J5 y SHCl.

Resultados: El suplemento J1 provocó la pérdida de peso más rápida en las ratas en comparación con los demás suplementos probados. Los pesos del riñón y el hígado de las ratas a las que se administraron suplementos adelgazantes adulterados con SHCl fueron superiores a los de las ratas de control. J1 indicó el suplemento con el mayor nivel de toxicidad. El grupo al que se administró J1 mostró los niveles más altos de toxicidad en todos los parámetros evaluados.

Conclusiones: Este estudio confirmó la toxicidad de los suplementos para adelgazar adulterados con SHCl en ratas, contribuyendo a la comprensión y tratamiento de los suplementos para adelgazar adulterados. Los suplementos dietéticos para la pérdida de peso deben ser examinados minuciosamente para detectar adulteraciones no declaradas con clorhidrato de sibutramina, con el fin de proteger la salud pública y reforzar las disposiciones legales.

Palabras Clave: adulteración; hepatotoxicidad; sibutramina clorhidrato; suplementos para adelgazar; toxicidad renal.

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Citation Format: Suparmi S, Yuliyanti S, Karyadini HW, Syamsudin AMR, Gau EK (2024) Toxicity of sibutramine hydrochloride-adulterated weight loss supplements in rats based on biochemical and organ weight parameters. J Pharm Pharmacogn Res 12(2): 363–370. https://doi.org/10.56499/jppres23.1852_12.2.363
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