Wound healing ability of flaxseed extracts

Excerpt:


J Pharm Pharmacogn Res 10(1): 1-12, 2022. DOI: https://doi.org/10.56499/jppres21.1125_10.1.1 Review Systematic review of flaxseed (Linum usitatissimum L.) extract and formulation in wound healing [Revisión sistemática sobre extracto y formulación de linaza (Linum usitatissimum L.) en la cicatrización de heridas] Abdul Talib Mat Sharil1, Mustafa Basma Ezzat2, Lestari Widya2, Mat Husin Amri Nurhakim1, Ab Razak Nor Hikmah2, Zainon … Continue reading Wound healing ability of flaxseed extracts



J Pharm Pharmacogn Res 10(1): 1-12, 2022.

DOI: https://doi.org/10.56499/jppres21.1125_10.1.1

Review

Systematic review of flaxseed (Linum usitatissimum L.) extract and formulation in wound healing

[Revisión sistemática sobre extracto y formulación de linaza (Linum usitatissimum L.) en la cicatrización de heridas]

Abdul Talib Mat Sharil1, Mustafa Basma Ezzat2, Lestari Widya2, Mat Husin Amri Nurhakim1, Ab Razak Nor Hikmah2, Zainon Nabilah Zafira2, Muhammad Salahuddin Haris1*

1Department of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, 25200 Kuantan, Pahang, Malaysia.

2Department of Fundamental Dental and Medical Sciences, Kulliyyah of Dentistry, International Islamic University Malaysia, Jalan Sultan Ahmad Shah, 25200, Kuantan, Pahang, Malaysia.

*E-mail: solah@iium.edu.my

Abstract

Context: Flaxseed constituents provide to antioxidant, anti-inflammatory, antimicrobial and wound healing benefits.

Aims: To systematically review the experimental evidence on the wound healing ability of flaxseed extracts and formulations.

Methods: Comprehensive searches in six databases (Scopus, Science Direct, Web of Science, PubMed, Google Scholar and Dimensions) were carried out from the beginning of databases until December 2020, according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. The terms used in searches were (Linum usitatissimum L., flaxseed, linseed, flax) AND (extract) AND (wound heal, heal, heal type, wound) for collection of articles, with only articles in English and research articles were included. Transgenic term were excluded. AXIS tool was chosen to assess the quality and risk of bias. The data were then categorised in term of extracts, laboratory formulation, and wound healing.

Results: In total, 999 articles were collected and screened based on the pre-determined inclusion and exclusion criteria. Finally, 10 articles were included in the review. The majority of publications reported significant findings of flaxseed oil on wound healing regardless of extraction method and formulation. Healing parameters on excision, incision, and burn wound models were studied. Lack of laboratory formulation mentioned in the collected articles gave limitation impact on this study.

Conclusions: Flaxseed oil formulation appears to exert a positive effect on wound healing. Therefore, extensive studies needed to evaluate the transportation of flaxseed phytochemicals into skin dermis by advanced drug formulation.

Keywords: extraction; flaxseed; formulation; Linum usitatissimum L.; systematic review; wound healing.

This image has an empty alt attribute; its file name is jppres_pdf_free.png
Resumen

Contexto: Los componentes de la linaza proporcionan beneficios antioxidantes, antiinflamatorios, antimicrobianos y de cicatrización de heridas.

Objetivos: Revisar sistemáticamente las evidencias experimentales sobre la capacidad de cicatrización de heridas de los extractos y formulaciones de linaza.

Métodos: Se realizaron búsquedas integrales en seis bases de datos (Scopus, Science Direct, Web of Science, PubMed, Google Scholar y Dimensions) desde el inicio de las bases de datos hasta diciembre de 2020, según Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) protocolo. Los términos utilizados en las búsquedas fueron (Linum usitatissimum L., flaxseed, linseed, flax) AND (extracto) AND (herida curar, curar, curar tipo, herida) para la colección de artículos, con solo artículos en inglés y se incluyeron artículos de investigación. Se excluyeron los términos transgénicos. Se eligió la herramienta AXIS para evaluar la calidad y el riesgo de sesgo. Luego, los datos se clasificaron en términos de extractos, formulación de laboratorio y cicatrización de heridas.

Resultados: En total, se recopilaron y seleccionaron 999 artículos según los criterios de inclusión y exclusión predeterminados. Finalmente, se incluyeron 10 artículos en la revisión. La mayoría de las publicaciones informaron hallazgos significativos del aceite de linaza en la cicatrización de heridas, independientemente del método de extracción y la formulación. Se estudiaron los parámetros de curación en modelos de escisión, incisión y quemaduras. La falta de formulación de laboratorio mencionada en los artículos recopilados dio un impacto de limitación en este estudio.

Conclusiones: La formulación de aceite de linaza parece ejercer un efecto positivo en la cicatrización de heridas. Por lo tanto, se necesitaban estudios extensos para evaluar el transporte de fitoquímicos de la linaza a la dermis de la piel mediante una formulación avanzada de fármacos.

Palabras Clave: extracción; cicatrización de herida; formulación; Linum usitatissimum; revisión sistemática; semilla de lino.

This image has an empty alt attribute; its file name is jppres_pdf_free.png
https://jppres.com/jppres/pdf/vol10/jppres21.1125_10.1.1.pdf
Citation Format: Mat Sharil AT, Basma Ezzat M, Widya L, Amri Nurhakim MH, Nor Hikmah AR, Nabilah Zafira Z, Haris MS (2022) Systematic review of flaxseed (Linum usitatissimum L.) extract and formulation in wound healing. J Pharm Pharmacogn Res 10(1): 1–12. https://doi.org/10.56499/jppres21.1125_10.1.1

© 2022 Journal of Pharmacy & Pharmacognosy Research (JPPRes)

Ageratum conyzoides and eggshell membrane hydrolysates in chronic inflammation
J. Pharm. Pharmacogn. Res., vol. 12, no. 5, pp. 972-993, Sep-Oct 2024. DOI: https://doi.org/10.56499/jppres24.1956_12.5.972 Original Article Anti-inflammatory effect of the mixture of Ageratum conyzoides L. extract and eggshell membrane hydrolysates and in silico active compound predictions [Efecto antiinflamatorio de la mezcla de extracto de Ageratum conyzoides L. e hidrolizados de membrana de cáscara de huevo, … Continue reading Ageratum conyzoides and eggshell membrane hydrolysates in chronic inflammation
SS-31 for diabetic nephropathy
J. Pharm. Pharmacogn. Res., vol. 12, no. 5, pp. 956-971, Sep-Oct 2024. DOI: https://doi.org/10.56499/jppres23.1904_12.5.956 Review SS-31 protects diabetic nephropathy progression: A systematic review of in vivo and in vitro studies [El SS-31 protege la progresión de la nefropatía diabética: Una revisión sistemática de estudios in vivo e in vitro] Jonathan Christianto Sutadji1#, Dian Anggraini Permatasari … Continue reading SS-31 for diabetic nephropathy
Hypertension knowledge and its associated factors in primary care
J. Pharm. Pharmacogn. Res., vol. 12, no. 5, pp. 943-955, Sep-Oct 2024. DOI: https://doi.org/10.56499/jppres24.1955_12.5.943 Original Article Hypertension knowledge and its associated factors among hypertensive patients in primary care settings in Central Vietnam: A cross-sectional study [Conocimiento de la hipertensión y sus factores asociados entre pacientes hipertensos en entornos de atención primaria en el centro de … Continue reading Hypertension knowledge and its associated factors in primary care

© 2013-2020 by the authors; licensee JPPRes, Antofagasta, Chile. This journal is an open-access journal distributed under the terms and conditions of the Creative Commons Attribution license-Non Commercial 4.0 international. The content on this site is intended for health professionals. If you are not a health professional, please talk to your doctor about any doubts or concerns regarding your health

Made with ♥ by AVAGAX Studio