{"id":19068,"date":"2024-11-29T11:30:11","date_gmt":"2024-11-29T14:30:11","guid":{"rendered":"https:\/\/jppres.com\/jppres\/?p=19068"},"modified":"2024-11-29T13:16:40","modified_gmt":"2024-11-29T16:16:40","slug":"anti-inflammatory-and-phytochemicals-of-macaranga-peltata-and-pongamia-pinnata","status":"publish","type":"post","link":"https:\/\/jppres.com\/jppres\/anti-inflammatory-and-phytochemicals-of-macaranga-peltata-and-pongamia-pinnata\/","title":{"rendered":"Anti-inflammatory and phytochemicals of Macaranga peltata and Pongamia pinnata"},"content":{"rendered":"

J. Pharm. Pharmacogn. Res., vol. 13, no. 2, pp. 662-671, Mar-Apr 2025<\/strong>.<\/p>\r\n\r\n\r\n\r\n

DOI: https:\/\/doi.org\/10.56499\/jppres24.1997_13.2.662<\/a><\/p>\r\n\r\n\r\n\r\n

Original Article<\/strong><\/p>\r\n\r\n\r\n\r\n

Anti-inflammatory activity and phytochemical analysis of Macaranga peltata <\/i>Boiv. Ex Baill. leaves and Pongamia pinnata<\/i> (L.) Pierre. seeds<\/h1>\r\n\r\n\r\n\r\n

[Actividad antiinflamatoria y an\u00e1lisis fitoqu\u00edmico de hojas de Macaranga peltata<\/i> Boiv. Ex Baill. y semillas de Pongamia pinnata<\/i> (L.) Pierre.]<\/h2>\r\n\r\n\r\n\r\n

Honnesh N. Honnappa1<\/sup>, Basavaraj Metikurki2<\/sup>, V. Kusum Devi3<\/sup>, Santanu Saha4*<\/sup><\/h3>\r\n\r\n\r\n\r\n

1<\/sup>Department of Pharmacognosy, Nitte College of Pharmaceutical Sciences, 6429, NITTE Campus, Govindapura, Gollahalli, Yelahanka, Bangalore – 560064, Karnataka, India.<\/p>\r\n

2<\/sup>Department of Pharmaceutical Chemistry, Nitte College of Pharmaceutical Sciences, 6429, NITTE Campus, Govindapura, Gollahalli, Yelahanka, Bangalore – 560064, Karnataka, India.<\/p>\r\n

3<\/sup>Department of Pharmaceutics, Nitte College of Pharmaceutical Sciences, 6429, NITTE Campus, Govindapura, Gollahalli, Yelahanka, Bangalore – 560064, Karnataka, India.<\/p>\r\n

4<\/sup>Department of Pharmacognosy, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Panner, Deralakatte, Mangaluru-575018, Karnataka, India.<\/p>\r\n

*E-mail: santanusaha@nitte.edu.in<\/a><\/p>\r\n\r\n\r\n\r\n

Abstract<\/strong><\/p>\r\n\r\n\r\n\r\n

Context<\/em>: Traditional medicinal plant knowledge represents one of the oldest and most valuable contributions to the health sector of humanity. It serves as an essential guide to humans to develop better and healthier well-being. Medicinal plants possess phytoconstituents which exhibit enormous therapeutic effects.<\/p>\r\n

Aims<\/em>: To evaluate the in vitro<\/em> and in vivo<\/em> anti-inflammatory activity of Macaranga peltata<\/em> (MPCF) and Pongamia pinnata<\/em> (PPEAF) fractions and estimate the phytochemicals responsible for their therapeutic action.<\/p>\r\n

Methods<\/em>: Plant extracts and fractions were tested for their in vitro<\/em> anti-inflammatory properties using the bovine serum albumin method and in vivo<\/em> activity using the carrageenan-induced rat paw edema model. The selected fragments were analyzed for phytochemicals such as flavonoids, tannins, and total phenolics.<\/p>\r\n

Results<\/em>: The extract yields indicate that P. pinnata<\/em> contains non-polar compounds and M. peltata<\/em> contains polar phytocompounds. Both the MPCF and PPEAF were found to contain flavonoids. However, MPCF also contained tannins and phenolic compounds that were found in lesser percentages in PPEAF.<\/p>\r\n

Conclusions<\/em>: The chloroform fraction of M. peltata<\/em> and ethyl acetate fraction of P. pinnata<\/em> showed significant anti-inflammatory activity compared to the positive control group.<\/p>\r\n

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Keywords<\/em>: bovine serum albumin; carrageenan; inflammation; Macaranga peltata<\/em>; Pongamia pinnata<\/em>.<\/p>\r\n\r\n\r\n\r\n

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