{"id":19712,"date":"2025-05-19T23:48:02","date_gmt":"2025-05-20T03:48:02","guid":{"rendered":"https:\/\/jppres.com\/jppres\/?p=19712"},"modified":"2025-05-19T23:48:02","modified_gmt":"2025-05-20T03:48:02","slug":"sea-cucumber-compounds-as-potential-antitumor-agents","status":"publish","type":"post","link":"https:\/\/jppres.com\/jppres\/sea-cucumber-compounds-as-potential-antitumor-agents\/","title":{"rendered":"Sea cucumber compounds as potential antitumor agents"},"content":{"rendered":"

J. Pharm. Pharmacogn. Res., vol. 13, no. 5, pp. 1372-1384, Sep-Oct 2025<\/strong>.<\/p>\r\n\r\n\r\nDOI: https:\/\/doi.org\/10.56499\/jppres24.2119_13.5.1372<\/a>\r\n\r\n\r\n

Review<\/strong><\/p>\r\n\r\n

Bioactive compounds and biological mechanism of sea cucumber as potential antitumor agents: A review<\/h1>\r\n\r\n

[Compuestos bioactivos y mecanismo biol\u00f3gico del pepino de mar como potenciales agentes antitumorales: Una revisi\u00f3n]<\/h2>\r\n\r\n

Nurhidayati Nurhidayati1,2<\/sup>, Yuyun Yueniwati Prabowowati3<\/sup>, Nurdiana Nurdiana4<\/sup>, Happy Kurnia Permatasari5<\/sup>, Rohadi Muhammad Rosyidi6<\/sup>, Agustina Tri Endharti7*<\/sup><\/h3>\r\n\r\n

1<\/sup>Doctoral Program in Medical Sciences, Faculty of Medicine, Universitas Brawijaya, Indonesia.<\/p>\r\n

2<\/sup>Department of Pharmacology, Faculty of Medicine, Universitas Mataram, Indonesia.<\/p>\r\n

3<\/sup>Department of Radiology, Faculty of Medicine, Universitas Brawijaya, Indonesia.<\/p>\r\n

4<\/sup>Department of Pharmacology, Faculty of Medicine, Universitas Brawijaya, Indonesia.<\/p>\r\n

5<\/sup>Department of Biochemistry, Faculty of Medicine, Universitas Brawijaya, Indonesia.<\/p>\r\n

6<\/sup>Department of Neurosurgery, Faculty of Medicine, Universitas Mataram, Indonesia.<\/p>\r\n

7<\/sup>Department of Parasitology, Faculty of Medicine, Universitas Brawijaya, Indonesia.<\/p>\r\n

*E-mail: tinapermana.fk@ub.ac.id<\/a><\/p>\r\n\r\n

Abstract<\/strong><\/p>\r\n\r\n

Context<\/em>: The goal of cancer therapy is to eliminate tumor cells with the fewest side effects and injury to healthy tissue. This renders the use of natural ingredients, generally low in toxicity, a wise choice. Among the many marine organisms that have nutritional and therapeutic qualities, one that is quite popular is the sea cucumber.<\/p>\r\n

Aims<\/em>: To identify the antitumor effects of sea cucumber extracts.<\/p>\r\n

Methods<\/em>: This review followed the preferred reporting items for systematic reviews and meta-analysis guidelines of the Reporting System for Systematic Reviews and Meta-analyses (PRISMA). The keywords used were \u201c((sea cucumber) AND (treatment)) AND (cancer)) AND (animal)\u201d. Studies included in this review were original articles published between January 2019 and April 2024.<\/p>\r\n

Results<\/em>: Based on the search results and predetermined keywords, 623 studies were generated. After filtering out duplicate studies, 33 articles were obtained, then proceeded to the full-text screening stage regarding the research design, resulting in 10 articles that could be further analyzed in this systematic review. Sea cucumber-derived compounds have been proven in vitro<\/em> and in vivo<\/em> in murine models to have the ability to suppress the growth of various types of human tumor cells through various mechanisms, including cytotoxic activity, induction of apoptosis, cell cycle arrest, reduction of tumor growth, suppression of tumor cell invasion and metastasis, as well as inhibition of angiogenesis.<\/p>\r\n

Conclusions<\/em>: Various bioactive compounds found in sea cucumbers have proven to have suppressive effects on the growth of various human tumors.<\/p>\r\n

Keywords<\/em>: cancer; sea cucumber; treatment.<\/p>\r\n\r\n

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Resumen<\/h4>\r\n\r\n

Contexto<\/em>: El objetivo de la terapia contra el c\u00e1ncer es eliminar las c\u00e9lulas tumorales con la menor cantidad de efectos secundarios y lesiones al tejido sano. Esto hace que el uso de ingredientes naturales, generalmente de baja toxicidad, sea una opci\u00f3n inteligente. Entre los muchos organismos marinos que tienen cualidades nutricionales y terap\u00e9uticas, uno que es bastante popular es el pepino de mar.<\/p>\r\n

Objetivos<\/em>: Identificar los efectos antitumorales de los extractos de pepino de mar.<\/p>\r\n

M\u00e9todos:<\/em> Esta revisi\u00f3n sigui\u00f3 los elementos de informe preferidos para revisiones sistem\u00e1ticas y pautas de metaan\u00e1lisis del Sistema de Informes para Revisiones Sistem\u00e1ticas y Metaan\u00e1lisis (PRISMA). Las palabras clave utilizadas fueron \u201c((pepino de mar) AND (tratamiento)) AND (c\u00e1ncer)) AND (animal)\u201d. Los estudios incluidos en esta revisi\u00f3n fueron art\u00edculos originales publicados entre enero de 2019 y abril de 2024.<\/p>\r\n

Resultados<\/em>: Con base en los resultados de la b\u00fasqueda y palabras clave predeterminadas, se generaron 623 estudios. Despu\u00e9s de filtrar los estudios duplicados, se obtuvieron 33 art\u00edculos, luego se procedi\u00f3 a la etapa de selecci\u00f3n de texto completo con respecto al dise\u00f1o de la investigaci\u00f3n, lo que dio como resultado 10 art\u00edculos que podr\u00edan analizarse m\u00e1s a fondo en esta revisi\u00f3n sistem\u00e1tica. Se ha demostrado in vitro<\/em> e in vivo<\/em> en modelos murinos que los compuestos derivados del pepino de mar tienen la capacidad de suprimir el crecimiento de varios tipos de c\u00e9lulas tumorales humanas a trav\u00e9s de varios mecanismos, incluida la actividad citot\u00f3xica, la inducci\u00f3n de la apoptosis, la detenci\u00f3n del ciclo celular, la reducci\u00f3n del crecimiento tumoral, la supresi\u00f3n de la invasi\u00f3n y met\u00e1stasis de c\u00e9lulas tumorales, as\u00ed como la inhibici\u00f3n de la angiog\u00e9nesis.<\/p>\r\n

Conclusiones<\/em>: Varios compuestos bioactivos encontrados en los pepinos de mar han demostrado tener efectos supresores sobre el crecimiento de varios tumores humanos.<\/p>\r\n

<\/p>\r\n

Palabras Clave<\/em>: c\u00e1ncer; pepino de mar; tratamiento.<\/p>\r\n\r\n

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Citation Format:<\/strong> Nurhidayati N, Prabowowati YY, Nurdiana N, Permatasari HK, Rosyidi RM, Endharti ATG (2025) Bioactive compounds and biological mechanism of sea cucumber as potential antitumor agents: A review. J Pharm Pharmacogn Res 13(5): 1372\u20131384. https:\/\/doi.org\/10.56499\/jppres24.2119_13.5.1372<\/a><\/pre>\r\n\r\n
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\u00a9 2025 Journal of Pharmacy & Pharmacognosy Research<\/p>","protected":false},"excerpt":{"rendered":"
J. Pharm. Pharmacogn. Res., vol. 13, no. 5, pp. 1372-1384, Sep-Oct 2025. DOI: https:\/\/doi.org\/10.56499\/jppres24.2119_13.5.1372 Review Bioactive compounds and biological mechanism of sea cucumber as potential antitumor agents: A review [Compuestos bioactivos y mecanismo biol\u00f3gico del pepino de mar como potenciales agentes antitumorales: Una revisi\u00f3n] Nurhidayati Nurhidayati1,2, Yuyun Yueniwati Prabowowati3, Nurdiana Nurdiana4, Happy Kurnia Permatasari5, Rohadi … Continue reading Sea cucumber compounds as potential antitumor agents<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[37],"tags":[],"class_list":["post-19712","post","type-post","status-publish","format-standard","hentry","category-pharmaceutical-science"],"brizy_media":[],"_links":{"self":[{"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/posts\/19712","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/comments?post=19712"}],"version-history":[{"count":0,"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/posts\/19712\/revisions"}],"wp:attachment":[{"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/media?parent=19712"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/categories?post=19712"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/tags?post=19712"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}