{"id":20261,"date":"2025-10-26T14:25:21","date_gmt":"2025-10-26T17:25:21","guid":{"rendered":"https:\/\/jppres.com\/jppres\/?p=20261"},"modified":"2025-10-26T14:31:50","modified_gmt":"2025-10-26T17:31:50","slug":"zingiber-officinale-and-gastroprotection","status":"publish","type":"post","link":"https:\/\/jppres.com\/jppres\/zingiber-officinale-and-gastroprotection\/","title":{"rendered":"Zingiber officinale and gastroprotection"},"content":{"rendered":"

J. Pharm. Pharmacogn. Res., vol. 13, no. 6, pp. 1978-1995, Nov-Dec 2025<\/strong>.<\/p>\r\n\r\n\r\n\r\n

DOI: https:\/\/doi.org\/10.56499\/jppres25.2370_13.6.1978<\/a><\/p>\r\n\r\n\r\n\r\n

Review<\/strong><\/p>\r\n\r\n\r\n\r\n

Gastroprotective effects of Zingiber officinale <\/i>in rodent models of peptic ulcers: A systematic review and meta-analysis<\/h1>\r\n\r\n\r\n\r\n

[Efectos gastroprotectores de Zingiber officinale<\/i> en modelos de roedores con \u00falceras p\u00e9pticas: una revisi\u00f3n sistem\u00e1tica y un metan\u00e1lisis]<\/h2>\r\n\r\n\r\n\r\n

Coana Sukmagautama1,2*<\/sup>, Reviono3<\/sup>, Wachid Putranto4<\/sup>, Eti P. Pamungkasari5<\/sup>, Hartono5<\/sup>, Risya Cilmiaty5<\/sup>, Paramasari Dirgahayu6<\/sup><\/h3>\r\n\r\n\r\n\r\n

1<\/sup>Doctoral Program of Medical Sciences, Universitas Sebelas Maret, Surakarta, Indonesia.<\/p>\r\n

2<\/sup>Gastroenterology and Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Sebelas, Surakarta, Indonesia.<\/p>\r\n

3<\/sup>Department of Pulmonology Medicine, Faculty of Medicine, Universitas Sebelas Surakarta, Indonesia.<\/p>\r\n

4<\/sup>Department of Internal Medicine, Faculty of Medicine, Universitas Sebelas, Surakarta, Indonesia.<\/p>\r\n

5<\/sup>Department of Public Health, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia.<\/p>\r\n

6<\/sup>Department of Parasitology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia.<\/p>\r\n

*E-mail: coana.sg@staff.uns.ac.id<\/a><\/p>\r\n\r\n\r\n\r\n

Abstract<\/strong><\/p>\r\n\r\n\r\n\r\n

Context<\/em>: Peptic ulcer remains a significant global health concern, particularly in low-resource settings. Conventional treatments are often associated with side effects and recurrence, prompting interest in herbal therapies such as Zingiber officinale<\/em> (ginger).<\/p>\r\n

Aims<\/em>: To explore the gastroprotective efficacy of Z. officinale<\/em> in preclinical models of experimentally induced peptic ulcer.<\/p>\r\n

Methods<\/em>: Electronic databases (Scopus, ScienceDirect, and PubMed) were searched for relevant studies published between 2015 and 2024. Eligible studies included rodent models of peptic ulcer treated with Z. officinale<\/em> and reporting ulcer index outcomes. Risk of bias was assessed using SYRCLE\u2019s tool, and meta-analysis was performed using Review Manager 5.4.1 software. Standardized mean differences (SMD) with 95% confidence intervals (CI) were calculated using a random-effects model.<\/p>\r\n

Results<\/em>: Five experimental animal studies from 2015 onwards to assess the gastroprotective effects of Z. officinale<\/em>, involving 240 rodents with peptic ulcers induced via WIR stress, ethanol, HCl, or diclofenac, were included. Z. officinale<\/em>, administered in various forms, significantly reduced ulcer severity compared to placebo (SMD = -5.35; 95% CI: -6.56 to -4.10; I\u00b2 = 79%) and showed efficacy comparable to standard therapies (SMD = 2.88; 95% CI: 1.36 to 4.41; I\u00b2 = 91) as proton pump inhibitor (PPI) and H2 blockers.<\/p>\r\n

Conclusions<\/em>: Z. officinale<\/em> exhibits significant gastroprotective activity in animal models of peptic ulcer. These findings support its potential as a candidate for further development in ulcer therapy, although standardized protocols and clinical trials are warranted.<\/p>\r\n

Keywords<\/em>: gastroprotection; rats; review article; therapy; <\/em>ulcer index; Zingiber officinale<\/em>.<\/p>\r\n\r\n\r\n\r\n

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Resumen<\/h4>\r\n\r\n\r\n\r\n

Contexto<\/em>: La \u00falcera p\u00e9ptica sigue siendo un problema de salud global importante, especialmente en entornos de bajos recursos. Los tratamientos convencionales suelen asociarse con efectos secundarios y recurrencia, lo que ha despertado el inter\u00e9s en terapias herbales como el Zingiber officinale<\/em> (jengibre).<\/p>\r\n

Objetivos<\/em>: Explorar la eficacia gastroprotectora de Z. officinale<\/em> en modelos precl\u00ednicos de \u00falcera p\u00e9ptica inducida experimentalmente.<\/p>\r\n

M\u00e9todos:<\/em> Se buscaron estudios relevantes publicados entre 2015 y 2024 en bases de datos electr\u00f3nicas (Scopus, ScienceDirect y PubMed). Los estudios elegibles incluyeron modelos de roedores de \u00falcera p\u00e9ptica tratados con Z. officinale<\/em> que reportaran resultados del \u00edndice de \u00falcera. El riesgo de sesgo se evalu\u00f3 mediante la herramienta SYRCLE y el metaan\u00e1lisis se realiz\u00f3 con el software Review Manager 5.4.1. Se calcularon las diferencias de medias estandarizadas (DME) con intervalos de confianza (IC) del 95% mediante un modelo de efectos aleatorios.<\/p>\r\n

Resultados<\/em>: Se incluyeron cinco estudios experimentales en animales, realizados a partir de 2015, para evaluar los efectos gastroprotectores de Z. officinale<\/em>, en 240 roedores con \u00falceras p\u00e9pticas inducidas mediante estr\u00e9s WIR, etanol, HCl o diclofenaco. Z. officinale<\/em>, administrado en diversas presentaciones, redujo significativamente la gravedad de la \u00falcera en comparaci\u00f3n con placebo (DME = -5,35; IC del 95 %: -6,56 a -4,10; I\u00b2 = 79 %) y mostr\u00f3 una eficacia comparable a la de las terapias est\u00e1ndar (DME = 2,88; IC del 95 %: 1,36 a 4,41; I\u00b2 = 91) como inhibidor de la bomba de protones (IBP) y bloqueadores H2.<\/p>\r\n

Conclusiones<\/em>: Z. officinale<\/em> exhibe una actividad gastroprotectora significativa en modelos animales de \u00falcera p\u00e9ptica. Estos hallazgos respaldan su potencial como candidato para un mayor desarrollo en el tratamiento de la \u00falcera, aunque se justifican protocolos estandarizados y ensayos cl\u00ednicos.<\/p>\r\n

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Palabras Clave<\/em>: art\u00edculo de revisi\u00f3n; gastroprotecci\u00f3n; \u00edndice de \u00falcera; ratas; terapia; Zingiber officinale<\/em>.<\/p>\r\n\r\n\r\n\r\n

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Citation Format: <\/strong>Sukmagautama C, Reviono, Putranto W, Pamungkasari EP, Hartono, Cilmiaty R, Dirgahayu P (2025) Gastroprotective effects of Zingiber officinale <\/em>in rodent models of peptic ulcers: A systematic review and meta-analysis. J Pharm Pharmacogn Res 13(6): 1978\u20131995. https:\/\/doi.org\/10.56499\/jppres25.2370_13.6.1978<\/a><\/pre>\r\n\r\n\r\n\r\n
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\u00a9 2025 Journal of Pharmacy & Pharmacognosy Research<\/p>","protected":false},"excerpt":{"rendered":"
J. Pharm. Pharmacogn. Res., vol. 13, no. 6, pp. 1978-1995, Nov-Dec 2025. DOI: https:\/\/doi.org\/10.56499\/jppres25.2370_13.6.1978 Review Gastroprotective effects of Zingiber officinale in rodent models of peptic ulcers: A systematic review and meta-analysis [Efectos gastroprotectores de Zingiber officinale en modelos de roedores con \u00falceras p\u00e9pticas: una revisi\u00f3n sistem\u00e1tica y un metan\u00e1lisis] Coana Sukmagautama1,2*, Reviono3, Wachid Putranto4, Eti … Continue reading Zingiber officinale and gastroprotection<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[37],"tags":[],"class_list":["post-20261","post","type-post","status-publish","format-standard","hentry","category-pharmaceutical-science"],"brizy_media":[],"_links":{"self":[{"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/posts\/20261","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/comments?post=20261"}],"version-history":[{"count":0,"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/posts\/20261\/revisions"}],"wp:attachment":[{"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/media?parent=20261"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/categories?post=20261"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/tags?post=20261"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}