{"id":20844,"date":"2026-07-13T13:03:25","date_gmt":"2026-07-13T17:03:25","guid":{"rendered":"https:\/\/jppres.com\/jppres\/?p=20844"},"modified":"2026-08-20T15:55:57","modified_gmt":"2026-08-20T19:55:57","slug":"bioactivity-of-lavandula-coronopifolia-oils","status":"publish","type":"post","link":"https:\/\/jppres.com\/jppres\/bioactivity-of-lavandula-coronopifolia-oils\/","title":{"rendered":"Bioactivity of Lavandula coronopifolia oils"},"content":{"rendered":"

J. Pharm. Pharmacogn. Res., vol. 14, no. 3, Article ID 2854, May-Jun 2026<\/strong>.<\/p>\r\n\r\n\r\n\r\n

DOI: https:\/\/doi.org\/10.56499\/jppres_14.3.2854<\/a><\/p>\r\n\r\n\r\n\r\n

Original Article<\/strong><\/p>\r\n\r\n\r\n\r\n

Authentication, volatile profiling, and anti-Pseudomonas aeruginosa<\/i> activity of Lavandula coronopifolia<\/i> Poir. oils<\/h1>\r\n\r\n

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[Autenticaci\u00f3n, perfil vol\u00e1til y actividad anti-Pseudomonas aeruginosa<\/i> de los aceites de Lavandula coronopifolia<\/i> Poir.]<\/h2>\r\n\r\n

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Fatma M. Abdel Bar1*<\/sup>, Ayman A. Salkini1<\/sup>, Razan F. Alotaibi2<\/sup>, Rawan S. Alweh2<\/sup>, Engy Elekhnawy3<\/sup>, Mai H. ElNaggar4<\/sup><\/h3>\r\n\r\n

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1<\/sup>Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia.<\/p>\r\n

2<\/sup>College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia.<\/p>\r\n

3<\/sup>Microbiology and Immunology Department, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt.<\/p>\r\n

4<\/sup>Department of Pharmacognosy, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.<\/p>\r\n

*E-mail: f.abdelbar@psau.edu.sa<\/a><\/p>\r\n\r\n

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Abstract<\/strong><\/p>\r\n\r\n\r\n\r\n

Context<\/em>: Lavandula coronopifolia<\/em> Poir. is used in traditional medicine, but quality-control markers and comparative bioactivity data for its volatile fractions remain limited.<\/p>\r\n

Aims<\/em>: The study was designed to authenticate commercial dried flower samples of L. coronopifolia<\/em>, compare essential and cohobation oil profiles, and evaluate antibacterial and antibiofilm activity against Pseudomonas aeruginosa<\/em>.<\/p>\r\n

Methods<\/em>: Powder microscopy was used to document diagnostic characters. Essential and cohobation oils from three samples were obtained by hydrodistillation and analyzed by GC-MS. Preliminary antibacterial screening against 20 P. aeruginosa<\/em> isolates was evaluated by agar well diffusion and broth microdilution. Biofilm biomass was assessed using the crystal violet assay. Docking against the LasR ligand-binding domain and SwissADME predictions were used as exploratory in silico<\/em> analyses.<\/p>\r\n

Results<\/em>: Candelabra-type covering trichomes, lamiaceous and bicapitate glandular trichomes, diacytic stomata, and hexacolpate pollen grains were observed. Linalool, camphor, endo<\/em>-borneol, 1,8-cineole, linalyl formate, linalool oxides, and linalyl acetate were identified as major constituents. Cohobation oils showed lower MIC values than essential oils. The proportion of strong plus moderate biofilm-producing isolates decreased after treatment, especially with Coh-2. Docking predicted favorable accommodation of trans<\/em>-linalool oxide and linalyl acetate within the LasR ligand-binding domain.<\/p>\r\n

Conclusions<\/em>: Integrated microscopy, volatile profiling, and biological testing supported the quality assessment of L. coronopifolia<\/em>. Further standardized antimicrobial, antibiofilm, cytotoxicity, and LasR-validation assays are required.<\/p>\r\n

Keywords<\/em>: anti-bacterial agents; biofilms; gas chromatography-mass spectrometry; plant oils; Pseudomonas aeruginosa<\/em>; quorum sensing.<\/p>\r\n\r\n

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Resumen<\/h4>\r\n\r\n\r\n\r\n

Contexto<\/em>: Lavandula coronopifolia<\/em> Poir. es una planta medicinal tradicional cuyas caracter\u00edsticas de control de calidad y bioactividad de sus fracciones vol\u00e1tiles permanecen poco estudiadas.<\/p>\r\n

Objetivos<\/em>: Autenticar muestras comerciales de flores secas de L. coronopifolia<\/em>, comparar la composici\u00f3n de los aceites esenciales y de cohobaci\u00f3n y evaluar sus actividades antibacterianas y antibiofilm frente a Pseudomonas aeruginosa<\/em>.<\/p>\r\n

M\u00e9todos:<\/em> La microscop\u00eda de polvo permiti\u00f3 identificar caracteres diagn\u00f3sticos. Los aceites se obtuvieron por hidrodestilaci\u00f3n y se analizaron mediante GC-MS. La actividad antibacteriana contra 20 aislamientos de P. aeruginosa<\/em> se determin\u00f3 mediante difusi\u00f3n en agar y microdiluci\u00f3n en caldo, mientras que la formaci\u00f3n de biofilm se evalu\u00f3 con cristal violeta. Se efectu\u00f3 acoplamiento molecular sobre el dominio de uni\u00f3n al ligando de LasR y se predijeron las propiedades fisicoqu\u00edmicas y farmacocin\u00e9ticas de los principales constituyentes mediante SwissADME.<\/p>\r\n

Resultados<\/em>: Se identificaron tricomas de cobertura tipo candelabro, tricomas glandulares lami\u00e1ceos y bicapitados, estomas diac\u00edticos y polen hexacolpado. Los principales constituyentes fueron linalool, alcanfor, endo-borneol, 1,8-cineol, formato de linalilo, \u00f3xidos de linalool y acetato de linalilo. Los aceites de cohobaci\u00f3n presentaron menores CIM y redujeron la proporci\u00f3n de aislamientos productores de biofilm fuerte y moderado, especialmente Coh-2. El docking predijo una interacci\u00f3n favorable del \u00f3xido de trans-linalool y el acetato de linalilo con LasR, y SwissADME mostr\u00f3 perfiles de similitud con f\u00e1rmacos generalmente favorables.<\/p>\r\n

Conclusiones<\/em>: La integraci\u00f3n de la microscop\u00eda, el perfilado de vol\u00e1tiles y los ensayos biol\u00f3gicos aporta herramientas para la evaluaci\u00f3n de la calidad de L.<\/em> coronopifolia<\/em>, aunque se requieren estudios adicionales.<\/p>\r\n\r\n\r\n\r\n

Palabras Clave<\/em>: aceites vegetales; agentes antibacterianos; biofilmes; cromatograf\u00eda de gases-espectrometr\u00eda de masas; detecci\u00f3n de qu\u00f3rum; Pseudomonas aeruginosa<\/em>.<\/p>\r\n\r\n

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Citation Format: <\/strong>Abdel Bar FM, Salkini AA, Alotaibi RF, Alweh RS, Elekhnawy E, ElNaggar MH (2026) Authentication, volatile profiling, and anti-Pseudomonas aeruginosa<\/em> activity of Lavandula coronopifolia<\/em> Poir. oils. J Pharm Pharmacogn Res 14(3): 2854. https:\/\/doi.org\/10.56499\/jppres_14.3.2854<\/a><\/pre>\r\n\r\n
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\u00a9 2026 Journal of Pharmacy & Pharmacognosy Research<\/p>","protected":false},"excerpt":{"rendered":"
J. Pharm. Pharmacogn. Res., vol. 14, no. 3, Article ID 2854, May-Jun 2026. DOI: https:\/\/doi.org\/10.56499\/jppres_14.3.2854 Original Article Authentication, volatile profiling, and anti-Pseudomonas aeruginosa activity of Lavandula coronopifolia Poir. oils   [Autenticaci\u00f3n, perfil vol\u00e1til y actividad anti-Pseudomonas aeruginosa de los aceites de Lavandula coronopifolia Poir.]   Fatma M. Abdel Bar1*, Ayman A. Salkini1, Razan F. Alotaibi2, … Continue reading Bioactivity of Lavandula coronopifolia oils<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[37],"tags":[],"class_list":["post-20844","post","type-post","status-publish","format-standard","hentry","category-pharmaceutical-science"],"brizy_media":[],"_links":{"self":[{"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/posts\/20844","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/comments?post=20844"}],"version-history":[{"count":0,"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/posts\/20844\/revisions"}],"wp:attachment":[{"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/media?parent=20844"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/categories?post=20844"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/tags?post=20844"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}