{"id":342,"date":"2014-06-13T00:26:16","date_gmt":"2014-06-13T04:26:16","guid":{"rendered":"https:\/\/jppres.com\/jppres\/?p=342"},"modified":"2024-02-14T01:56:28","modified_gmt":"2024-02-14T04:56:28","slug":"allium-sativum-prevents-k2cr2o7-induced-nephrotoxicity-and-lipid-oxidation","status":"publish","type":"post","link":"https:\/\/jppres.com\/jppres\/allium-sativum-prevents-k2cr2o7-induced-nephrotoxicity-and-lipid-oxidation\/","title":{"rendered":"Allium sativum prevents K2Cr2O7-induced nephrotoxicity and lipid oxidation"},"content":{"rendered":"
J Pharm Pharmacogn Res 2(2): 45-52, 2014.<\/strong><\/h6>\n

DOI: https:\/\/doi.org\/10.56499\/jppres14.020_2.2.45<\/a><\/p>\n

Original Article<\/h3>\n

Allium sativum<\/i> aqueous extract prevents potassium dichromate-induced nephrotoxicity and lipid oxidation in rats<\/h2>\n

[El extracto acuoso de Allium sativum<\/i> previene la nefrotoxicidad y la oxidaci\u00f3n lip\u00eddica inducida por dicromato de potasio en ratas]<\/h2>\n

Sergio L. Becerra-Torresa*<\/sup>, C\u00e9sar Soria-Fregozoa<\/sup>, Fernando Jaramillo-Ju\u00e1rezb<\/sup>, Jos\u00e9 L. Moreno-Hern\u00e1ndez-Duquec<\/sup><\/h3>\n
a<\/sup>Laboratorio de Psicobiolog\u00eda y Biolog\u00eda Molecular, Departamento de Ciencias de la Tierra y de la Vida, Centro Universitario de los Lagos. Universidad de Guadalajara. Lagos de Moreno, Jalisco, M\u00e9xico.<\/span>
\n b<\/sup>Laboratorio de Toxicolog\u00eda, Departamento de Fisiolog\u00eda y Farmacolog\u00eda, Centro de Ciencias B\u00e1sicas. Universidad Aut\u00f3noma de Aguascalientes. Aguascalientes, Aguascalientes, M\u00e9xico.<\/span>
\n c<\/sup>Laboratorio de Instrumentaci\u00f3n, Departamento de Qu\u00edmica, Centro de Ciencias B\u00e1sicas. Universidad Aut\u00f3noma de Aguascalientes. Aguascalientes, Aguascalientes, M\u00e9xico.<\/span>
\n * E-mail: luciobecerratorres@hotmail.com<\/a><\/span><\/address>\n
Abstract<\/h5>\n

Context: The potassium dichromate (K2Cr2O7) induces nephrotoxicity by oxidative stress mechanisms.
\nAims: To study the potential protection of an aqueous extract of Allium sativum<\/em> against the K2Cr2O7-induced nephrotoxicity and lipid oxidation in rats.
\nMethods: Twenty four hours after treatment, biomarkers such as proteinuria, creatinine clearance, malondialdehyde production, specific enzyme activity of gamma glutamyl transpeptidase and alanine aminopeptidase, and renal clearance of para-aminohippuric acid and inulin were measured.
\nResults: The K2Cr2O7 caused significant renal dysfunction, but A. sativum<\/em> extract prevented this condition by improving all measured biomarkers.
\nConclusions: A single injection of K2Cr2O7 induced nephrotoxicity in rats, but the supply of an Allium sativum<\/em> aqueous extract prevented the disorders caused by this metal.<\/p>\n

Keywords:<\/strong> Creatinine; garlic extract; inulin; malondialdehyde; proteinuria; renal clearance.<\/p>\n

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Resumen<\/h5>\n

Contexto: El dicromato de potasio (K2Cr2O7) induce nefrotoxicidad por mecanismos de estr\u00e9s oxidativo.
\nObjetivos: Estudiar la protecci\u00f3n potencial de un extracto acuoso de Allium sativum<\/em> contra la nefrotoxicidad y oxidaci\u00f3n lip\u00eddica inducida por K2Cr2O7 en ratas.
\nM\u00e9todos: Veinticuatro horas despu\u00e9s del tratamiento se midieron biomarcadores tales como proteinuria, aclaramiento de creatinina, producci\u00f3n de malondialdeh\u00eddo, actividad espec\u00edfica de las enzimas transpeptidasa de gamma glutamilo y aminopeptidasa de alanina, y aclaramiento de \u00e1cido paraaminohip\u00farico e inulina.
\nResultados: El K2Cr2O7 caus\u00f3 disfunci\u00f3n renal significativa, pero el extracto de Allium sativum<\/em> previno esta condici\u00f3n mejorando todos los biomarcadores valorados.
\nConclusiones: Una sola inyecci\u00f3n de K2Cr2O7 provoc\u00f3 nefrotoxicidad, pero el suministro de un extracto acuoso de Allium sativum<\/em> evit\u00f3 las alteraciones causadas por este metal, en ratas.<\/p>\n

Palabras Clave:<\/strong> Creatinina; extracto de ajo; inulina; malondialdeh\u00eddo; proteinuria; aclaramiento.<\/p>\n

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Citation Format:<\/strong> Sergio L. Becerra-Torres, C\u00e9sar Soria-Fregozo, Fernando Jaramillo-Ju\u00e1rez, Jos\u00e9 L. Moreno-Hern\u00e1ndez-Duque (2014) Allium sativum<\/em> aqueous extract prevents potassium dichromate-induced nephrotoxicity and lipid oxidation in rats. J Pharm Pharmacogn Res 2(2):45-52. DOI: https:\/\/doi.org\/10.56499\/jppres14.020_2.2.45<\/a><\/span><\/pre>\n
This article has been cited by:<\/strong><\/pre>\n
Abeer M. El-Mahalaway, Maysara M. Salem and Ayman M. Mousa (2015) The effect of potassium dichromate on convoluted tubules of the kidney of adult male albino rats and the possible protective role of ginseng: a histological and immunohistochemical study. The Egyptian Journal of Histology 38:157-167 DOI: 10.1097\/01.EHX.0000464738.41270.06<\/a><\/pre>\n
\u00a9 2014 Journal of Pharmacy & Pharmacognosy Research (JPPRes)<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"
J Pharm Pharmacogn Res 2(2): 45-52, 2014. DOI: https:\/\/doi.org\/10.56499\/jppres14.020_2.2.45 Original Article Allium sativum aqueous extract prevents potassium dichromate-induced nephrotoxicity and lipid oxidation in rats [El extracto acuoso de Allium sativum previene la nefrotoxicidad y la oxidaci\u00f3n lip\u00eddica inducida por dicromato de potasio en ratas] Sergio L. Becerra-Torresa*, C\u00e9sar Soria-Fregozoa, Fernando Jaramillo-Ju\u00e1rezb, Jos\u00e9 L. Moreno-Hern\u00e1ndez-Duquec aLaboratorio … Continue reading Allium sativum prevents K2Cr2O7-induced nephrotoxicity and lipid oxidation<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13,5,6,7,47,9],"tags":[],"class_list":["post-342","post","type-post","status-publish","format-standard","hentry","category-biochemistry","category-medicinal-plants","category-natural-products","category-pharmacognosy","category-preclinical-research","category-toxicology"],"brizy_media":[],"_links":{"self":[{"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/posts\/342","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/comments?post=342"}],"version-history":[{"count":0,"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/posts\/342\/revisions"}],"wp:attachment":[{"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/media?parent=342"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/categories?post=342"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jppres.com\/jppres\/wp-json\/wp\/v2\/tags?post=342"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}