J. Pharm. Pharmacogn. Res., vol. 14, no. 1, Article ID 2477, Jan-Feb 2026.
DOI: https://doi.org/10.56499/jppres_14.1.2477Review
Potential of seaweed bioactives for pharmaceutical applications
[Potencial de los bioactivos de las algas marinas para aplicaciones farmacéuticas]
Muhammad Maskur1,2, Asep A. Prihanto3*, Muhamad Firdaus3, Rahmi Nurdiani3
1Doctoral Program, Faculty of Fisheries and Marine Science, Brawijaya University, Jl.Veteran, Malang, East Java, 65145, Indonesia.
2Polytechnic of Marine and Fisheries Bone, Jl. Sungai Musi Km 9, Bone, South Sulawesi, 92718, Indonesia.
3Department of Fishery Product Technology, Faculty of Fisheries and Marine Science, Brawijaya University, Jl. Veteran, Malang, East Java, 65145, Indonesia.
*E-mail: asep_awa@ub.ac.id
Abstract
Context: Seaweed is a notable source of bioactive constituents, including polysaccharides, fatty acids, proteins, polyphenols, and pigments. Bioactives exhibit many biological activities, including antioxidant, anti-inflammatory, anticancer, antidiabetic, and antiobesity properties. Due to its abundant beneficial compounds and balanced composition, seaweed has emerged as a viable and unique source of novel pharmaceutical materials.
Aims: To consolidate current knowledge on seaweed bioactives, highlight eco-friendly extraction techniques, and explore their prospective pharmaceutical applications.
Methods: A thorough literature review was performed to collect pertinent studies on the potential of seaweed bioactives for pharmaceutical applications. The search spanned many databases and comprised papers published between 2002 and 2024. The chosen papers were meticulously analyzed to obtain relevant information for this critical review.
Results: Bioactives from seaweed are a promising source for application in the pharmaceutical field. Various bioactives, including polysaccharides, fatty acids, polyphenols, proteins, and pigments, can exhibit antioxidant, anti-inflammatory, anticancer, antidiabetic, and anti-obesity activities. Eco-friendly extraction methods for maximizing bioactive yield from seaweed include ultrasound-assisted extraction, supercritical fluid extraction, enzymatic-assisted extraction, microwave-assisted extraction, and pressurized liquid extraction.
Conclusions: Future strategies should emphasize the application of bioactive seaweed-derived chemicals in the pharmaceutical sector, given existing challenges such as drug resistance. Moreover, seaweed has emerged as a viable alternative for nanoparticle synthesis, hence enhancing the potential application of these by-products in engineering and medical sciences.
Keywords: anti-inflammatory; antioxidant; bioactive; eco-friendly extraction; marine pharmaceuticals; seaweed metabolites.
Resumen
Contexto: Las algas marinas son una fuente importante de constituyentes bioactivos, como polisacáridos, ácidos grasos, proteínas, polifenoles y pigmentos. Estos bioactivos presentan diversas actividades biológicas, incluyendo propiedades antioxidantes, antiinflamatorias, anticancerígenas, antidiabéticas y antiobesidad. Gracias a su abundante contenido de compuestos beneficiosos y a su composición equilibrada, las algas marinas se han consolidado como una fuente viable y única de nuevos materiales farmacéuticos.
Objetivos: Consolidar el conocimiento actual sobre los bioactivos de las algas marinas, destacar técnicas de extracción ecológicas y explorar sus posibles aplicaciones farmacéuticas.
Métodos: Se realizó una revisión bibliográfica exhaustiva para recopilar estudios relevantes sobre el potencial de los bioactivos de las algas marinas para aplicaciones farmacéuticas. La búsqueda abarcó diversas bases de datos e incluyó artículos publicados entre 2002 y 2024. Los artículos seleccionados se analizaron meticulosamente para obtener información relevante para esta revisión crítica.
Resultados: Los bioactivos de las algas marinas constituyen una fuente prometedora para su aplicación en el campo farmacéutico. Diversos compuestos bioactivos, como polisacáridos, ácidos grasos, polifenoles, proteínas y pigmentos, pueden presentar bioactividad, incluyendo actividades antioxidantes, antiinflamatorias, anticancerígenas, antidiabéticas y antiobesidad. Los métodos de extracción ecológicos para maximizar el rendimiento de compuestos bioactivos de las algas marinas incluyen la extracción asistida por ultrasonidos, la extracción con fluidos supercríticos, la extracción enzimática, la extracción asistida por microondas y la extracción con líquidos presurizados.
Conclusiones: Las estrategias futuras deberían priorizar la aplicación de compuestos bioactivos derivados de algas marinas en el sector farmacéutico, dado que la resistencia a los fármacos figura entre los desafíos actuales. Además, las algas marinas se han consolidado como una alternativa viable para la síntesis de nanopartículas, lo que amplía el potencial de aplicación de estos subproductos en las ciencias de la ingeniería y la medicina.
Palabras Clave: antiinflamatorio; antioxidante; bioactivo; extracción ecológica; productos farmacéuticos marinos; metabolitos de algas marinas.
Citation Format: Maskur M, Prihanto AA, Firdaus M, Nurdiani R (2026) Potential of seaweed bioactives for pharmaceutical applications. J Pharm Pharmacogn Res 14(1): 2477. https://doi.org/10.56499/jppres_14.1.2477
References
Abdelhamid A, Lajili S, Elkaibi MA, Ben Salem Y, Abdelhamid A, Muller CD, Majdoub H, Kraiem J, Bouraoui A (2019) Optimized extraction, preliminary characterization and evaluation of the in vitro anticancer activity of phlorotannin-rich fraction from the brown seaweed Cystoseira sedoides. J Aquat Food Prod Technol 28(9): 892–909. https://doi.org/10.1080/10498850.2019.1662865
Abdel-Karim OH, Abo-Shady AM, Ismail GA, Gheda SF (2022) Potential effect of Turbinaria decurrens acetone extract on the biochemical and histological parameters of alloxan-induced diabetic rats. Int J Environ Health Res 32(7): 1447–1468. https://doi.org/10.1080/09603123.2021.1888895
Abd-Ellatef GEF, Ahmed OM, Abdel-Reheim ES, Abdel-Hamid AHZ (2017) Ulva lactuca polysaccharides prevent Wistar rat breast carcinogenesis through the augmentation of apoptosis, enhancement of antioxidant defense system, and suppression of inflammation. Breast Cancer: Targets Ther 9: 67–83. https://doi.org/10.2147/BCTT.S125165
ADA (2008) American Dietetic Association. ADA Evidence Analysis Manual 2008. ADA Quality Criteria Checklist - Primary Research. pp. 55–56.
Adam F, Abert-Vian M, Peltier G, Chemat F (2012) Solvent-free ultrasound-assisted extraction of lipids from fresh microalgae cells: A green clean and scalable process. Bioresour Technol 114: 457–465. https://doi.org/10.1016/j.biortech.2012.02.096
Ahn GN, Kim KN, Cha SH, Song CB, Lee J, Heo MS, Yeo IK, Lee NH, Jee YH, Kim JS, Heu MS, Jeon YJ (2007) Antioxidant activities of phlorotannins purified from Ecklonia cava on free radical scavenging using ESR and H2O2-mediated DNA damage. Eur Food Res Technol 226(1–2): 71–79. https://doi.org/10.1007/s00217-006-0510-y
Ahn JH, Kim D, Park CW, Kim B, Sim H, Kim HS, Lee TK, Lee JC, Yang GE, Her Y, Park JH, Sim TH, Lee HS, Won MH (2020) Laminarin attenuates ultraviolet-induced skin damage by reducing superoxide anion levels and increasing endogenous antioxidants in the dorsal skin of mice. Mar Drugs 18(7): 345. https://doi.org/10.3390/md18070345
Al Elq A, Alfayez AA, AlQahtani MI, Alshahrani RS, Alotaibi GA, Aldakheel AA, Alhammad AA, Bakr Mohamed RH, Jarrar M, Abusalah MAH, Al-Bsheish M (2023) The effects of various teaching methods on chest x-ray interpretation skills among medical students and interns: a systematic review. Cureus 15(18): e44399. https://doi.org/10.7759/cureus.44399
Alam A, Sarker ZI, Ghafoor K, Happy RA (2017) Bioactive Compounds and Extraction Techniques. In Recovering Bioactive Compounds from Agricultural Wastes. Wiley & Sons Inc., pp 33–53. https://doi.org/10.1002/9781119168850.ch2
Alboofetileh M, Rezaei M, Tabarsa M, Rittà M, Donalisio M, Mariatti F, You SG, Lembo D, Cravotto G (2018) Effect of different non-conventional extraction methods on the antibacterial and antiviral activity of fucoidans extracted from Nizamuddinia zanardinii. Int J Biol Macromol 124: 131–137. https://doi.org/10.1016/j.ijbiomac.2018.11.201
Anaelle T, Serrano Leon E, Laurent V, Elena I, Mendiola JA, Stéphane C, Nelly K, Stéphane LB, Luc M, Valérie SP (2013) Green improved processes to extract bioactive phenolic compounds from brown macroalgae using Sargassum muticum as model. Talanta 104: 44–52. https://doi.org/10.1016/j.talanta.2012.10.088
Artan M, Li Y, Karadeniz F, Lee SH, Kim MM, Kim SK (2008) Anti-HIV-1 activity of phloroglucinol derivative, 6,6′-bieckol from Ecklonia cava. Bioorg Med Chem 16(17): 7921–7926. https://doi.org/10.1016/j.bmc.2008.07.078
Aryee AN, Agyei D, Akanbi TO (2018) Recovery and utilization of seaweed pigments in food processing. Curr Opin Food Sci 19: 113–119. https://doi.org/10.1016/j.cofs.2018.03.013
Awang AN, Ng JL, Matanjun P, Sulaiman MR, Tan TS, Ooi YBH (2014) Anti-obesity property of the brown seaweed, Sargassum polycystum using an in vivo animal model. J Appl Phycol 26(2): 1043–1048. https://doi.org/10.1007/s10811-013-0149-6
Baghel RS, Choudhary B, Pandey S, Pathak PK, Patel MK, Mishra A (2023) Rehashing our insight of seaweeds as a potential source of foods, nutraceuticals, and pharmaceuticals. Foods 12(19): 3642. https://doi.org/10.3390/foods12193642
Bak UG, Nielsen CW, Marinho GS, Gregersen Ó, Jónsdóttir R, Holdt SL (2019) The seasonal variation in nitrogen, amino acid, protein and nitrogen-to-protein conversion factors of commercially cultivated Faroese Saccharina latissima. Algal Res 42: 101576. https://doi.org/10.1016/j.algal.2019.101576
Barbosa F, Pinto E, Kijjoa A, Pinto M, Sousa E (2020) Targeting antimicrobial drug resistance with marine natural products. Int J Antimicrob Agents 56(1): 106005. https://doi.org/10.1016/j.ijantimicag.2020.106005
Baweja P, Kumar S, Sahoo D, Levine I (2016) Biology of Seaweeds. In Seaweed in Health and Disease Prevention. Elsevier Inc., pp. 41–106. https://doi.org/10.1016/B978-0-12-802772-1.00003-8
Beaulieu L, Bondu S, Doiron K, Rioux LE, Turgeon SL (2015) Characterization of antibacterial activity from protein hydrolysates of the macroalga Saccharina longicruris and identification of peptides implied in bioactivity. J Funct Foods 17: 685–697. https://doi.org/10.1016/j.jff.2015.06.026
Bedoux G, Hardouin K, Burlot AS, Bourgougnon N (2014) Bioactive components from seaweeds: Cosmetic applications and future development. In: Advances in Botanical Research. Elsevier, vol. 71, pp. 345–378. https://doi.org/10.1016/B978-0-12-408062-1.00012-3
Belattmania Z, Engelen AH, Pereira H, Serrão EA, Custódio L, Varela JC, Zrid R, Reani A, Sabour B (2018) Fatty acid composition and nutraceutical perspectives of brown seaweeds from the Atlantic coast of Morocco. Int Food Res J 25(4): 1520–1527.
Belwal T, Chemat F, Venskutonis PR, Cravotto G, Jaiswal DK, Bhatt ID, Devkota HP, Luo Z (2020) Recent advances in scaling-up of non-conventional extraction techniques: Learning from successes and failures. TrAC 127: 115895. https://doi.org/10.1016/j.trac.2020.115895
Berri M, Olivier M, Holbert S, Dupont J, Demais H, Le Goff M, Collen PN (2017) Ulvan from Ulva armoricana (Chlorophyta) activates the PI3K/Akt signalling pathway via TLR4 to induce intestinal cytokine production. Algal Res 28: 39–47. https://doi.org/10.1016/j.algal.2017.10.008
Bogolitsyn KG, Kaplitsin PA, Dobrodeeva LK, Druzhinina AS, Ovchinnikov DV, Parshina AE, Shulgina EV (2017) Fatty acid composition and biological activity of supercritical extracts from arctic brown algae Fucus vesiculosus. Russ J Phys Chem 11(7): 1144–1152. https://doi.org/10.1134/S1990793117070065
Boulho R, Marty C, Freile-Pelegrín Y, Robledo D, Bourgougnon N, Bedoux G (2017) Antiherpetic (HSV-1) activity of carrageenans from the red seaweed Solieria chordalis (Rhodophyta, Gigartinales) extracted by microwave-assisted extraction (MAE). J Appl Phycol 29(5): 2219–2228. https://doi.org/10.1007/s10811-017-1192-5
Cao M, Li Y, Famurewa AC, Olatunji OJ (2021) Antidiabetic and nephroprotective effects of polysaccharide extract from the seaweed Caulerpa racemosa in high fructose-streptozotocin induced diabetic nephropathy. Diabetes Metab Syndr Obes 14: 2121–2131. https://doi.org/10.2147/DMSO.S302748
Casas MP, Conde E, Domínguez H, Moure A (2019) Ecofriendly extraction of bioactive fractions from Sargassum muticum. Process Biochem 79: 166–173. https://doi.org/10.1016/j.procbio.2018.12.021
Castro LSEPW, de Sousa Pinheiro T, Castro AJG, da Silva Nascimento Santos M, Soriano EM, Leite EL (2015) Potential anti-angiogenic, antiproliferative, antioxidant, and anticoagulant activity of anionic polysaccharides, fucans, extracted from brown algae Lobophora variegata. J Appl Phycol 27(3): 1315–1325. https://doi.org/10.1007/s10811-014-0424-1
Černá M (2011) Seaweed proteins and amino acids as nutraceuticals. In: Advances in Food and Nutrition Research. Elsevier Inc., vol. 64, pp. 297–312. https://doi.org/10.1016/B978-0-12-387669-0.00024-7
Charoensiddhi S, Conlon MA, Franco CMM, Zhang W (2017) The development of seaweed-derived bioactive compounds for use as prebiotics and nutraceuticals using enzyme technologies. Trends in Food Sci Technol 70: 20–33. https://doi.org/10.1016/j.tifs.2017.10.002
Chaves RP, Silva SR, Nascimento Neto LG, Carneiro RF, Silva ALC, Sampaio AH, Sousa BL, Cabral MG, Videira PA, Teixeira EH, Nagano CS (2018) Structural characterization of two isolectins from the marine red alga Solieria filiformis (Kützing) P.W. Gabrielson and their anticancer effect on MCF-7 breast cancer cells. Int J Biol Macromol 107(Part A): 1320–1329. https://doi.org/10.1016/j.ijbiomac.2017.09.116
Chemat F, Abert-Vian M, Fabiano-Tixier AS, Strube J, Uhlenbrock L, Gunjevic V, Cravotto G (2019) Green extraction of natural products. Origins, current status, and future challenges. TrAC 118: 248–263. https://doi.org/10.1016/j.trac.2019.05.037
Chemat F, Rombaut N, Sicaire AG, Meullemiestre A, Fabiano-Tixier AS, Abert-Vian M (2017) Ultrasound assisted extraction of food and natural products. Mechanisms, techniques, combinations, protocols and applications. A review. Ultrason Sonochem 34: 540–560. https://doi.org/10.1016/j.ultsonch.2016.06.035
Chen H, Yan X, Zhu P, Lin J (2006) Antioxidant activity and hepatoprotective potential of agaro- oligosaccharides in vitro and in vivo. Nutr J 5(1): 31. https://doi.org/10.1186/1475-2891-5-31
Chen SJ, Lin TB, Peng HY, Liu HJ, Lee AS, Lin CH, Tseng KW (2021) Cytoprotective potential of fucoxanthin in oxidative stress-induced age-related macular degeneration and retinal pigment epithelial cell senescence in vivo and in vitro. Mar Drugs 19(2): 114. https://doi.org/10.3390/MD19020114
Chen YDJ, Gong L, Hong Y, Hu C, Bao Y, Chen H, Liu L, Huang L, Zhao Y, Zhang J, He S, Yan X, Wu X, Cui W (2023) Fucoxanthin, a marine derived carotenoid, attenuates surgery-induced cognitive impairments via activating Akt and ERK pathways in aged mice. Phytomedicine 120: 155043. https://doi.org/10.1016/j.phymed.2023.155043
Chen YY, Xue YT (2018). Optimization of microwave assisted extraction, chemical characterization, and antitumor activities of polysaccharides from Porphyra haitanensis. Carbohydr Polym 206: 179–186. https://doi.org/10.1016/j.carbpol.2018.10.093
Cho M, You S (2015) Sulfated polysaccharides from green seaweeds. In: Kim SK (eds) Springer Handbook of Marine Biotechnology. Springer Handbooks. Berlin, Heidelberg: Springer, pp. 941–953. https://doi.org/10.1007/978-3-642-53971-8_40
Choi J, Kim HJ, Kim JH, Lee JW (2012) Enhanced biological activities of laminarin degraded by gamma-ray irradiation. J Food Biochem 36(4): 465–469. https://doi.org/10.1111/j.1745-4514.2011.00552.x
Choudhary B, Chauhan OP, Mishra A (2021) Edible seaweeds: A potential novel source of bioactive metabolites and nutraceuticals with human health benefits. Front Mar Sci 8: 740054. https://doi.org/10.3389/fmars.2021.740054
Cian RE, Garzón AG, Ancona DB, Guerrero LC, Drago SR (2015) Hydrolyzates from Pyropia columbina seaweed have antiplatelet aggregation, antioxidant and ACE I inhibitory peptides which maintain bioactivity after simulated gastrointestinal digestion. LWT - Food Sci Technol 64(2): 881–888. https://doi.org/10.1016/j.lwt.2015.06.043
Cloutier M, Mantovani D, Rosei F (2015) Antibacterial coatings: challenges, perspectives, and opportunities. Trends Biotechnol 33(11): 637–652. https://doi.org/10.1016/j.tibtech.2015.09.002
Cui Y, Zhu L, Li Y, Jiang S, Sun Q, Xie E, Chen H, Zhao Z, Qiao W, Xu J, Dong C (2021) Structure of a laminarin-type β-(1→3)-glucan from brown algae Sargassum henslowianum and its potential on regulating gut microbiota. Carbohydr Polym 255: 117389. https://doi.org/10.1016/j.carbpol.2020.117389
Dawczynski C, Schubert R, Jahreis G (2007) Amino acids, fatty acids, and dietary fibre in edible seaweed products. Food Chem 103(3): 891–899. https://doi.org/10.1016/j.foodchem.2006.09.041
De las Heras B, Hortelano S (2009) Molecular basis of the anti-inflammatory effects of terpenoids. Inflamm Allergy Drug Targets 8(1): 28–39. https://doi.org/10.2174/187152809787582534
Devillé C, Damas J, Forget P, Dandrifosse G, Peulen O (2004) Laminarin in the dietary fibre concept. J Sci Food Agric 84(9): 1030–1038. https://doi.org/10.1002/jsfa.1754
Echave J, Otero P, Garcia-Oliveira P, Munekata PES, Pateiro M, Lorenzo JM, Simal-Gandara J, Prieto M A (2022) Seaweed-derived proteins and peptides: promising marine bioactives. Antioxidants 11(1): 176. https://doi.org/10.3390/antiox11010176
El Barky AR, Ezz AAH, Alm-Eldeen AAE, Hussein SA, Hafez YA, Mohamed TM (2017) Can stem cells ameliorate the pancreatic damage induced by streptozotocin in rats. Can J Diabetes 42(1): 61–70. https://doi.org/10.1016/j.jcjd.2017.04.002
El Shafay S, El-Sheekh M, Bases E, El-Shenody R (2022) Antioxidant, antidiabetic, anti-inflammatory and anticancer potential of some seaweed extracts. Food Sci Technol 42: e20521. https://doi.org/10.1590/fst.20521
El-Sheekh MM, El-Shenody RAEK, Bases EA, El Shafay SM (2021) Comparative assessment of antioxidant activity and biochemical composition of four seaweeds, rocky bay of Abu Qir in Alexandria, Egypt. Food Sci Technol 41(suppl 1): 29–40. https://doi.org/10.1590/fst.06120
Erpel F, Mateos R, Pérez-Jiménez J, Pérez-Correa JR (2020) Phlorotannins: From isolation and structural characterization, to the evaluation of their antidiabetic and anticancer potential. Food Res Int 137: 109589. https://doi.org/10.1016/j.foodres.2020.109589
Fabrowska J, Messyasz B, Pankiewicz R, Wilińska P, Łęska B (2018) Seasonal differences in the content of phenols and pigments in thalli of freshwater Cladophora glomerata and its habitat. Water Res 135: 66–74. https://doi.org/10.1016/j.watres.2018.02.020
Fayad S, Nehmé R, Tannoury M, Lesellier E, Pichon C, Morin P (2017) Macroalga Padina pavonica water extracts obtained by pressurized liquid extraction and microwave-assisted extraction inhibit hyaluronidase activity as shown by capillary electrophoresis. J Chromatogr A 1497: 19–27. https://doi.org/10.1016/j.chroma.2017.03.033
Fernando IPS, Nah JW, Jeon YJ (2016) Potential anti-inflammatory natural products from marine algae. Environ Toxicol Pharmacol 48: 22–30. https://doi.org/10.1016/j.etap.2016.09.023
Ferreira-Anta T, Torres MD, Dominguez H, Flórez-Fernández N (2023) Formulation of polymeric microparticles using eco-friendly extracted crude fucoidans from edible brown seaweed Undaria pinnatifida. Foods 12(9): 1859. https://doi.org/10.3390/foods12091859
Figueiredo JG, Bitencourt FS, Cunha TM, Luz PB, Nascimento KS, Mota MRL, Sampaio AH, Cavada BS, Cunha FQ, Alencar NMN (2010) Agglutinin isolated from the red marine alga Hypnea cervicornis J. Agardh reduces inflammatory hypernociception: Involvement of nitric oxide. Pharmacol Biochem Behav 96(4): 371–377. https://doi.org/10.1016/j.pbb.2010.06.008
Fimbres-Olivarria D, Carvajal-Millan E, Lopez-Elias JA, Martinez-Robinson KG, Miranda-Baeza A, Martinez-Cordova LR, Enriquez-Ocaña F, Valdez-Holguin JE (2018) Chemical characterization and antioxidant activity of sulfated polysaccharides from Navicula sp. Food Hydrocoll 75: 229–236. https://doi.org/10.1016/j.foodhyd.2017.08.002
Flórez-Fernández N, López-García M, González-Muñoz MJ, Vilariño JML, Domínguez H (2017) Ultrasound-assisted extraction of fucoidan from Sargassum muticum. J Appl Phycol 29(3): 1553–1561. https://doi.org/10.1007/s10811-016-1043-9
Francenia SN, Salas-Coronado R, Villanueva-Cañongo C, Hernández-Carlos B (2019) Antioxidant compounds and their antioxidant mechanism. In: Shalaby E (ed.), Antioxidants. IntechOpen, pp. 1–28. https://doi.org/10.5772/intechopen.85270
Gallego R, Bueno M, Herrero M (2019) Sub- and supercritical fluid extraction of bioactive compounds from plants, food-by-products, seaweeds and microalgae – an update. TrAC 116: 198–213. https://doi.org/10.1016/j.trac.2019.04.030
Ganesan AR, Tiwari U, Rajauria G (2019) Seaweed nutraceuticals and their therapeutic role in disease prevention. Food Sci Hum Wellness 8(3): 252–263. https://doi.org/10.1016/j.fshw.2019.08.001
García V, Uribe E, Vega-Gálvez A, Delporte C, Valenzuela-Barra G, López J, Pastén A (2020) Health-promoting activities of edible seaweed extracts from Chilean coasts: Assessment of antioxidant, anti-diabetic, anti-inflammatory and antimicrobial potential. Rev Chil Nutr 47(5): 792–800. https://doi.org/10.4067/S0717-75182020000500792
Garcia-Vaquero M, Rajauria G, O’Doherty JV, Sweeney T (2017) Polysaccharides from macroalgae: Recent advances, innovative technologies and challenges in extraction and purification. Food Res Int 99 (Part 3): 1011–1020. https://doi.org/10.1016/j.foodres.2016.11.016
Garcia-Vaquero MRG, Tiwari B, Sweeney T, O’Doherty J (2018) Extraction and yield optimisation of fucose, glucans and associated antioxidant activities from Laminaria digitata by applying response surface methodology to high intensity. Mar Drugs 16(8): 257. https://doi.org/10.3390/md16080257
Gheda S, Naby MA, Mohamed T, Pereira L, Khamis A (2021) Antidiabetic and antioxidant activity of phlorotannins extracted from the brown seaweed Cystoseira compressa in streptozotocin-induced diabetic rats. Environ Sci Pollut Res 28(18): 22886–22901. https://doi.org/10.1007/s11356-021-12347-5
Go H, Hwang HJ, Nam TJ (2010) A glycoprotein from Laminaria japonica induces apoptosis in HT-29 colon cancer cells. Toxicol In Vitro 24(6): 1546–1553. https://doi.org/10.1016/j.tiv.2010.06.018
Gómez-Guzmán M, Rodríguez-Nogales A, Algieri F, Gálvez J (2018) Potential role of seaweed polyphenols in cardiovascular-associated disorders. Mar Drugs 16(8): 250. https://doi.org/10.3390/md16080250
Grasa-López A, Miliar-García Á, Quevedo-Corona L, Paniagua-Castro N, Escalona-Cardoso G, Reyes-Maldonado E, Jaramillo-Flores ME (2016) Undaria pinnatifida and fucoxanthin ameliorate lipogenesis and markers of both inflammation and cardiovascular dysfunction in an animal model of diet-induced obesity. Mar Drugs 14(8): 148. https://doi.org/10.3390/md14080148
Gurpilhares DB, Cinelli LP, Simas NK, Pessoa A, Sette LD (2019) Marine prebiotics: Polysaccharides and oligosaccharides obtained by using microbial enzymes. Food Chem 280: 175–186. https://doi.org/10.1016/j.foodchem.2018.12.023
Habeebullah SFK, Alagarsamy S, Al-Haddad S, Al-Yamani F (2023) Composition, in vitro antioxidant and angiotensin-converting enzyme inhibitory effects of lipids isolated from fifteen species of seaweeds. Food Chem Adv 3: 100352. https://doi.org/10.1016/j.focha.2023.100352
Habeebullah SFK, Alagarsamy S, Arnous A, Jacobsen C (2021) Enzymatic extraction of antioxidant ingredients from Danish seaweeds and characterization of active principles. Algal Res 56: 102292. https://doi.org/10.1016/j.algal.2021.102292
Habeebullah SFK, Alagarsamy S, Sattari Z, Al-Haddad S, Fakhraldeen S, Al-Ghunaim A, Al-Yamani F (2019) Enzyme-assisted extraction of bioactive compounds from seaweeds and microalgae. TrAC 167: 117266. https://doi.org/10.1016/j.trac.2023.117266
Hall AC, Fairclough AC, Mahadevan K, Paxman JR (2012) Ascophyllum nodosum enriched bread reduces subsequent energy intake with no effect on post-prandial glucose and cholesterol in healthy, overweight males. A pilot study. Appetite 58(1): 379–386. https://doi.org/10.1016/j.appet.2011.11.002
Hardouin K, Burlot AS, Umami A, Tanniou A, Stiger-Pouvreau V, Widowati I, Bedoux G, Bourgougnon N (2014) Biochemical and antiviral activities of enzymatic hydrolysates from different invasive French seaweeds. J Appl Phycol 26(2): 1029–1042. https://doi.org/10.1007/s10811-013-0201-6
Harrysson H, Hayes M, Eimer F, Carlsson NG, Toth GB, Undeland I (2018) Production of protein extracts from Swedish red, green, and brown seaweeds, Porphyra umbilicalis Kützing, Ulva lactuca Linnaeus, and Saccharina latissima (Linnaeus) J. V. Lamouroux using three different methods. J Appl Phycol 30(6): 3565–3580. https://doi.org/10.1007/s10811-018-1481-7
He J, Xu Y, Chen H, Sun P (2016) Extraction, structural characterization, and potential antioxidant activity of the polysaccharides from four seaweeds. Int J Mol Sci 17(12): 1988. https://doi.org/10.3390/ijms17121988
Heavisides E, Rouger C, Reichel AF, Ulrich C, Wenzel-Storjohann A, Sebens S, Tasdemir D (2018) Seasonal variations in the metabolome and bioactivity profile of fucus vesiculosus extracted by an optimised, pressurised liquid extraction protocol. Mar Drugs 16(12): 503. https://doi.org/10.3390/md16120503
Herrero M, Sánchez-Camargo AP, Cifuentes A, Ibáñez E (2015) Plants, seaweeds, microalgae and food by-products as natural sources of functional ingredients obtained using pressurized liquid extraction and supercritical fluid extraction. TrAC 71: 26–38. https://doi.org/10.1016/j.trac.2015.01.018
Holanda ML, Melo VMM, Silva LMCM, Amorim RCN, Pereira MG, Benevides NMB (2005) Differential activity of a lectin from Solieria filiformis against human pathogenic bacteria. Braz J Med Biol Res 38(12): 1769–1773. https://doi.org/10.1590/S0100-879X2005001200005
Holdt SL, Kraan S (2011) Bioactive compounds in seaweed: Functional food applications and legislation. J Appl Phycol 23: 543–597. https://doi.org/10.1007/s10811-010-9632-5
Jagtap AS, Manohar CS, Ayyapankutty AMT, Meena SN (2021) Antioxidant and antiglycemic properties of macroalgae, an underutilized blue economy bioresource in India. Russ J Mar Biol 47(6): 489–497. https://doi.org/10.1134/S1063074021060067
Jaworowska A, Murtaza A (2023) Seaweed derived lipids are a potential anti-inflammatory agent: a review. Int J Environ Res Public Health 20(1): 730. https://doi.org/10.3390/ijerph20010730
Jia RB, Wu J, Li ZR, Ou ZR, Zhu Q, Sun B, Lin L, Zhao M (2020) Comparison of physicochemical properties and antidiabetic effects of polysaccharides extracted from three seaweed species. International J Biol Macromol 149: 81–92. https://doi.org/10.1016/j.ijbiomac.2020.01.111
Jiang RW, Hay ME, Fairchild CR, Prudhomme J, Roch KL, Aalbersberg W, Kubanek J (2008) Antineoplastic unsaturated fatty acids from Fijian macroalgae. Phytochemistry 69(13): 2495–2500. https://doi.org/10.1016/j.phytochem.2008.07.005
Jung HA, Jin SE, Ahn BR, Lee CM, Choi JS (2013) Anti-inflammatory activity of edible brown alga Eisenia bicyclis and its constituents fucosterol and phlorotannins in LPS-stimulated RAW264.7 macrophages. Food Chem Toxicol 59: 199–206. https://doi.org/10.1016/j.fct.2013.05.061
Kadam SU, O’Donnell CP, Rai DK, Hossain MB, Burgess CM, Walsh D, Tiwari BK (2015) Laminarin from Irish brown seaweeds Ascophyllum nodosum and Laminaria hyperborea: Ultrasound assisted extraction, characterization and bioactivity. Mar Drugs 13(7): 4270–4280. https://doi.org/10.3390/md13074270
Kadam SU, Tiwari BK, Smyth TJ, Donnell CPO (2014) Optimization of ultrasound assisted extraction of bioactive components from brown seaweed Ascophyllum nodosum using response surface methodology. Ultrason Sonochem 23: 308–316. https://doi.org/10.1016/j.ultsonch.2014.10.007
Kannan RR, Aderogba MA, Ndhlala AR, Stirk WA, Van Staden J (2014) Acetylcholinesterase inhibitory activity of phlorotannins isolated from the brown alga Ecklonia maxima (Osbeck) Papenfuss. Food Res Int 54(1): 1250–1254. https://doi.org/10.1016/j.foodres.2012.11.017
Kazłowska K, Hsu T, Hou CC, Yang WC, Tsai GJ (2010) Anti-inflammatory properties of phenolic compounds and crude extract from Porphyra dentata. J Ethnopharmacol 128(1): 123–130. https://doi.org/10.1016/j.jep.2009.12.037
Khalid S, Abbas M, Saeed F, Bader-Ul-Ain H, Ansar Rasul RSH (2018) Therapeutic potential of seaweed bioactive compounds. In: Maiti S (ed.), Seaweed Biomaterials. IntechOpen, pp. 1–25. https://doi.org/10.5772/intechopen.74060
Khan BM, Qiu HM, Xu SY, Liu Y, Cheong KL (2020) Physicochemical characterization and antioxidant activity of sulphated polysaccharides derived from Porphyra haitanensis. Int J Biol Macromol 145: 1155–1161. https://doi.org/10.1016/j.ijbiomac.2019.10.040
Kim AR, Shin TS, Lee MS, Park JY, Park KE, Yoon NY, Kim JS, Choi JS, Jang BC, Byun DS, Park NK, Kim HR (2009) Isolation and Identification of phlorotannins from Ecklonia stolonifera with antioxidant and anti-inflammatory properties. J Agric Food Chem 57(9): 3483–3489. https://doi.org/10.1021/jf900820x
Kim JH, Yun EJ, Yu S, Kim KH, Kang NJ (2017) Different levels of skin whitening activity among 3,6-anhydro-L-galactose, agarooligosaccharides, and neoagarooligosaccharides. Mar Drugs 15(10): 321. https://doi.org/10.3390/md15100321
Kim YR, Park S, Kim JY (2024) Therapeutic potential of seaweed extracts: In vitro and in vivo studies on alleviating inflammation and enhancing intestinal barrier function. Food Biosci 59: 103774. https://doi.org/10.1016/j.fbio.2024.103774
Kong CS, Kim JA, Yoon NY, Kim SK (2009) Induction of apoptosis by phloroglucinol derivative from Ecklonia cava in MCF-7 human breast cancer cells. Food Chem Toxicol 47(7): 1653–1658. https://doi.org/10.1016/j.fct.2009.04.013
Kulshreshtha G, Burlot AS, Marty C, Critchley A, Hafting J, Bedoux G, Bourgougnon N, Prithiviraj B (2015) Enzyme-assisted extraction of bioactive material from Chondrus crispus and Codium fragile and its effect on Herpes simplex virus (HSV-1). Mar Drugs 13(1): 558–580. https://doi.org/10.3390/md13010558
Kumar LRG, Treesa PP, Anas KK, Tejpal CS, Chatterjee NS, Anupama TK, Geethalakshmi V, Anandan R, Jayarani R, Mathew S (2020) Screening of effective solvents for obtaining antioxidant-rich seaweed extracts using principal component analysis. J Food Process Preserv 44(9): 14716. https://doi.org/10.1111/jfpp.14716
Kumar M, Kumari P, Reddy CRK, Jha B (2014) Salinity and desiccation induced oxidative stress acclimation in seaweeds. In: Advances in Botanical Research. Elsevier, vol. 71, pp. 91-123 https://doi.org/10.1016/B978-0-12-408062-1.00004-4
Le B, Golokhvast KS, Yang SH, Sun S (2019) Optimization of microwave-assisted extraction of polysaccharides from Ulva pertusa and evaluation of their antioxidant activity. Antioxidants 8(5): 129. https://doi.org/10.3390/antiox8050129
Lee HG, Lu YA, Li X, Hyun JM, Kim HS, Lee JJ, Kim TH, Kim HM, Kang MC, Jeon YJ (2020) Anti-obesity effects of Grateloupia elliptica, a red seaweed, in mice with high-fat diet-induced obesity via suppression of adipogenic factors in white adipose tissue and increased thermogenic factors in brown adipose tissue. Nutrients 12(2): 308. https://doi.org/10.3390/nu12020308
Lee MS, Kwon MS, Choi JW, Shin T, No HK, Choi JS, Byun DS, Kim J, Kim HR (2012) Anti-inflammatory activities of an ethanol extract of Ecklonia stolonifera in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells. J Agric Food Chem 60(36): 9120–9129. https://doi.org/10.1021/jf3022018
Li YF, Udayakumar V, Sathuvan M, Liu Y, Liu X, Zhang YQ, Ma WY, Zhang W, Tang S, Cheong KL (2022) Effects of Laminarin zwitterionic carboxylate and sulfonate on the intestinal barrier function and gut microbiota. Carbohydr Polym 278: 118898. https://doi.org/10.1016/j.carbpol.2021.118898
Liu T, Li Q, Xu X, Li G, Tian C, Zhang T (2022) Molecular mechanisms of anti-cancer bioactivities of seaweed polysaccharides. Chin Herbal Med 14(4): 528–534. https://doi.org/10.1016/j.chmed.2022.02.003
Lomartire S, Gonçalves AMM (2022) An overview of potential seaweed-derived bioactive compounds for pharmaceutical applications. Mar Drugs 20(2): 141. https://doi.org/10.3390/md20020141
Lopes G, Sousa C, Valentão P, Andrade PB (2013) Sterols in algae and health. In: Bioactive Compounds from Marine Foods: Plant and Animal Sources, pp. 173–191. https://doi.org/10.1002/9781118412893.ch9
López-Hortas L, Gannon L, Moreira R, Chenlo F, Domínguez H, Torres MD (2018) Microwave hydrodiffusion and gravity (MHG) processing of Laminaria ochroleuca brown seaweed. J Clean Prod 197(Part 1): 1108–1116. https://doi.org/10.1016/j.jclepro.2018.06.274
Lorbeer AJ, Lahnstein J, Fincher GB, Su P, Zhang W (2015) Kinetics of conventional and microwave-assisted fucoidan extractions from the brown alga Ecklonia radiata. J Appl Phycol 27(5): 2079–2087. https://doi.org/10.1007/s10811-014-0446-8
Lordan S, Ross RP, Stanton C (2011) Marine bioactives as functional food ingredients: Potential to reduce the incidence of chronic diseases. Mar Drugs 9(6): 1056–1100. https://doi.org/10.3390/md9061056
Lu YA, Lee HG, Li X, Hyun JM, Kim HS, Kim TH, Kim HM, Lee JJ, Kang MC, Jeon YJ (2020) Anti-obesity effects of red seaweed, Plocamium telfairiae, in C57BL/6 mice fed a high-fat diet. Food Funct 11(3): 2299–2308. https://doi.org/10.1039/c9fo02924a
Manach C, Scalbert A, Morand C, Rémésy C, Jiménez L (2004) Polyphenols: Food sources and bioavailability. Am J Clin Nutr 79(5): 727–747. https://doi.org/10.1093/ajcn/79.5.727
Manzoor Z, Mathema VB, Chae D, Kang HK, Yoo ES, Jeon YJ, Koh YS (2013) Octaphlorethol a inhibits the CPG-induced inflammatory response by attenuating the mitogen-activated protein kinase and nf-κb pathways. Biosci Biotechnol Biochem 77(9): 1970–1972. https://doi.org/10.1271/bbb.130299
Marques F, Lopes D, Costa E, Conde T, Rego A, Ribeiro AI, Abreu MH, Domingues MR (2021) Seaweed blends as a valuable source of polyunsaturated and healthy fats for nutritional and food applications. Mar Drugs 19(12): 684. https://doi.org/10.3390/md19120684
Mekinić IG, Skroza D, Šimat V, Hamed I, Čagalj M, Perković ZP (2019) Phenolic content of brown algae (Pheophyceae) species: Extraction, identification, and quantification. Biomolecules 9(6): 244. https://doi.org/10.3390/biom9060244
Mendiola JA, Santoyo S, Cifuentes A, Reglero G, Ibáñez E, Javier SF (2008) Antimicrobial activity of sub- and supercritical CO2 extracts of the green alga Dunaliella salina. J Food Protect 71(10): 2138–2143. https://doi.org/10.4315/0362-028X-71.10.2138
Michalak I, Chojnacka K (2015) Algae as production systems of bioactive compounds. Eng Life Sci 15(2): 160–176. https://doi.org/10.1002/elsc.201400191
Mirzadeh M, Arianejad MR, Khedmat L (2019) Antioxidant, antiradical, and antimicrobial activities of polysaccharides obtained by microwave-assisted extraction method: A review. Carbohydr Polym 229: 115421. https://doi.org/10.1016/j.carbpol.2019.115421
Montero L, Sánchez-Camargo AP, García-Cañas V, Tanniou A, Stiger-Pouvreau V, Russo M, Rastrelli L, Cifuentes A, Herrero M, Ibáñez E (2016) Anti-proliferative activity and chemical characterization by comprehensive two-dimensional liquid chromatography coupled to mass spectrometry of phlorotannins from the brown macroalga Sargassum muticum collected on North-Atlantic coasts. J Chromatogr 1428: 115–125. https://doi.org/10.1016/j.chroma.2015.07.053
Muhammad M, Mohammad S, Ketut SI, Rahmatang (2023) Environmental-friendly extraction methods to produce bioactive compounds in seaweed. Res J Chem Environ 27(11): 114–121. https://doi.org/10.25303/2711rjce1140121
Nagappan T, Vairappan CS (2014) Nutritional and bioactive properties of three edible species of green algae, genus Caulerpa (Caulerpaceae). J Appl Phycol 26(2): 1019–1027. https://doi.org/10.1007/s10811-013-0147-8
Nagayama K, Iwamura Y, Shibata T, Hirayama I, Nakamura T (2002) Bactericidal activity of phlorotannins from the brown alga Ecklonia kurome. J Antimicrob Chemother 50(6): 889–893. https://doi.org/10.1093/jac/dkf222
Naveen J, Baskaran R, Baskaran V (2021) Profiling of bioactives and in vitro evaluation of antioxidant and antidiabetic property of polyphenols of marine algae Padina tetrastromatica. Algal Res 55: 102250. https://doi.org/10.1016/j.algal.2021.102250
Oliyaei N, Moosavi-Nasab M, Tamaddon AM, Tanideh N (2021) Antidiabetic effect of fucoxanthin extracted from Sargassum angustifolium on streptozotocin-nicotinamide-induced type 2 diabetic mice. Food Sci Nutr 9(7): 3521–3529. https://doi.org/10.1002/fsn3.2301
Ouzzani M, Hammady HM, Fedorowicz Z, Elmagarmid AK (2016) Rayyan—a web and mobile app for systematic reviews. Syst Rev 5(1): 210. https://doi.org/10.1186/s13643-016-0384-4
Pacheco LV, Parada J, Pérez-Correa JR, Mariotti-Celis MS, Erpel F, Zambrano A, Palacios M (2020) Bioactive polyphenols from southern Chile seaweed as inhibitors of enzymes for starch digestion. Mar Drugs 18(7): 353. https://doi.org/10.3390/md18070353
Page M, McKenzie J, Bossuyt P, Boutron I, Hoffmann T, Mulrow C, Shamseer L, Tetzlaff J, Akl E, Brennan S, Chou R, Glanville J, Grimshaw J, Hrobjartsson A, Lalu M, Li T, Loder E, MayoWilson E, McDonald S, McGuinness L, Moher D (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Int J Surg 88: 105906. https://doi.org/10.1016/j.ijsu.2021.105906
Pangestuti R, Kim S (2015) Seaweed proteins, peptides and amino acids. In: Seaweed Sustainabilit. Elsevier Inc., pp. 125–140. https://doi.org/10.1016/B978-0-12-418697-2.00006-4
Park SJ, Ryu J, Kim IH, Choi YH, Nam TJ (2014) Induction of apoptosis by a peptide from Porphyra yezoensis: Regulation of the insulin-like growth factor I receptor signaling pathway in MCF-7 cells. Int J Oncol 45(3): 1011–1016. https://doi.org/10.3892/ijo.2014.2509
Parys S, Kehraus S, Krick A, Glombitza KW, Carmeli S, Klimo K, Gerhäuser C, König GM (2010) In vitro chemopreventive potential of fucophlorethols from the brown alga Fucus vesiculosus L. by anti-oxidant activity and inhibition of selected cytochrome P450 enzymes. Phytochemistry 71(2–3): 221–229. https://doi.org/10.1016/j.phytochem.2009.10.020
Penuela A, Robledo D, Bourgougnon N, Bedoux G, Hernández-Nú E, Freile-Pelegrín Y (2018) Environmentally friendly valorization of Solieria filiformis (Gigartinales, Rhodophyta) from IMTA using a biorefinery concept. Mar Drugs 16(12): 487. https://doi.org/10.3390/md16120487
Perez MJ, Falque E, Dominguez H (2016) Antimicrobial action of compounds from marine seaweed. Mar Drugs 14(3): 52. https://doi.org/10.3390/md14030052
Pina-Pérez MC, Rivas A, Martínez A, Rodrigo D (2017) Antimicrobial potential of macro and microalgae against pathogenic and spoilage microorganisms in food. Food Chemistry 235: 34–44. https://doi.org/10.1016/j.foodchem.2017.05.033
Pirian K, Moein S, Sohrabipour J, Rabiei R, Blomster J (2017) Antidiabetic and antioxidant activities of brown and red macroalgae from the Persian Gulf. J Appl Phycol 29(6): 3151–3159. https://doi.org/10.1007/s10811-017-1152-0
Plaza M, Santoyo S, Jaime L, García-Blairsy RG, Herrero M, Señoráns FJ, Ibáñez E (2010) Screening for bioactive compounds from algae. J Pharm Biomed Anal 51(2): 450–455. https://doi.org/10.1016/j.jpba.2009.03.016
Plaza M, Turner C (2015) Pressurized hot water extraction of bioactives. TrAC 71: 39–54. https://doi.org/10.1016/j.trac.2015.02.022
Praveen MA, Parvathy KRK, Balasubramanian P, Jayabalan R (2019) An overview of extraction and purification techniques of seaweed dietary fibers for immunomodulation on gut microbiota. Trends Food Sci Technol 92: 46–64. https://doi.org/10.1016/j.tifs.2019.08.011
Puri M, Sharma D, Barrow CJ (2012) Enzyme-assisted extraction of bioactives from plants. Trends Biotechnol 30(1): 37–44. https://doi.org/10.1016/j.tibtech.2011.06.014
Qiu SM, Aweya JJ, Liu X, Liu Y, Tang S, Zhang W, Cheong KL (2022) Bioactive polysaccharides from red seaweed as potent food supplements: a systematic review of their extraction, purification, and biological activities. Carbohydr Polym 275: 118696. https://doi.org/10.1016/j.carbpol.2021.118696
Quitério E, Soares C, Ferraz R, Delerue-Matos C, Grosso C (2021) Marine health-promoting compounds: Recent trends for their characterization and human applications. Foods 10(12): 3100. https://doi.org/10.3390/foods10123100
Raguraman V, Mubarak AD, Narendrakumar G, Thirugnanasambandam R, Kirubagaran R, Thajuddin N (2018) Unraveling rapid extraction of fucoxanthin from Padina tetrastromatica: Purification, characterization and biomedical application. Process Biochem 73: 211–219. https://doi.org/10.1016/j.procbio.2018.08.006
Rajauria G, Ravindran R, Garcia-Vaquero M, Rai DK, Sweeney T, O’Doherty J (2021) Molecular characteristics and antioxidant activity of laminarin extracted from the seaweed species Laminaria hyperborea, using hydrothermal-assisted extraction and a multi-step purification procedure. Food Hydrocoll 112: 106332. https://doi.org/10.1016/j.foodhyd.2020.106332
Ren B, Chen C, Li C, Fu X, You L, Liu RH (2017) Optimization of microwave-assisted extraction of Sargassum thunbergii polysaccharides and its antioxidant and hypoglycemic activities. Carbohydr Polym 173: 192–201. https://doi.org/10.1016/j.carbpol.2017.05.094
Rodrigues D, Silva A, Amorim M, Pereira L, Rocha-santos TAP, Gomes AMP, Duarte AC, Freitas AC (2015) Impact of enzyme- and ultrasound-assisted extraction methods on biological properties of red, brown, and green seaweeds from the central west coast of Portugal. Agric Food Chem 63: 3177–3188. https://doi.org/10.1021/jf504220e
Rodríguez-Bernaldo de Quirós A, Lage-Yusty MA, López-Hernández J (2010) Determination of phenolic compounds in macroalgae for human consumption. Food Chem 121(2): 634–638. https://doi.org/10.1016/j.foodchem.2009.12.078
Rodriguez-Jasso RM, Mussatto SI, Pastrana L, Aguilar CN, Teixeira JA (2011) Microwave-assisted extraction of sulfated polysaccharides (fucoidan) from brown seaweed. Carbohydr Polym 86(3): 1137–1144. https://doi.org/10.1016/j.carbpol.2011.06.006
Ropellato J, Carvalho MM, Ferreira LG, Noseda MD, Zuconelli CR, Gonçalves AG, Ducatti DRB, Kenski JCN, Nasato PL, Winnischofer SMB, Duarte MER (2015) Sulfated heterorhamnans from the green seaweed Gayralia oxysperma: Partial depolymerization, chemical structure and antitumor activity. Carbohydr Polym 117: 476–485. https://doi.org/10.1016/j.carbpol.2014.09.089
Ruiz-Domínguez MC, Medina E, Salinas F, Bugueño W, Fuentes JL, Vílchez C, Garbayo I, Cerezal-Mezquita P (2022) Methodological optimization of supercritical fluid extraction of valuable bioactive compounds from the acidophilic microalga Coccomyxa onubensis. Antioxidants 11(7): 1248. https://doi.org/10.3390/antiox11071248
Safari P, Rezaei M, Shaviklo AR (2015) The optimum conditions for the extraction of antioxidant compounds from the Persian gulf green algae (Chaetomorpha sp.) using response surface methodology. J Food Sci Technol 52(5): 2974–2981. https://doi.org/10.1007/s13197-014-1355-1
Salehi B, Sharifi-rad J, Seca AML, Pinto DCGA (2019) Current trends on seaweeds: Looking at chemical. Molecules 24(22): 4182. https://doi.org/10.3390/molecules24224182
Sanjivkumar M, Chandran MN, Suganya AM, Immanuel G (2020) Investigation on bio-properties and in-vivo antioxidant potential of carrageenans against alloxan induced oxidative stress in Wistar albino rats. Int J Biol Macromol 151: 650–662. https://doi.org/10.1016/j.ijbiomac.2020.02.227
Saravana PS, Getachew AT, Cho YJ, Choi JH, Park YB, Woo HC, Chun BS (2017) Influence of co-solvents on fucoxanthin and phlorotannin recovery from brown seaweed using supercritical CO2. J Supercrit Fluids 120: 295–303. https://doi.org/10.1016/j.supflu.2016.05.037
Schmid M, Guihéneuf F, Stengel DB (2014) Fatty acid contents and profiles of 16 macroalgae collected from the Irish Coast at two seasons. J Appl Phycol 26(1): 451–463. https://doi.org/10.1007/s10811-013-0132-2
Senevirathne M, Kim SH, Siriwardhana N, Ha JH, Lee KW, Jeon YJ (2006) Antioxidant potential of Ecklonia cava on reactive oxygen species scavenging, metal chelating, reducing power, and lipid peroxidation inhibition. Food Sci Technol Int 12(1): 27–38. https://doi.org/10.1177/1082013206062422
Senthilkumar D, Jayanthi S (2016) Partial characterization and anticancer activities of purified glycoprotein extracted from green seaweed Codium decorticatum. J Funct Foods 25: 323–332. https://doi.org/10.1016/j.jff.2016.06.010
Shannon E, Abu-Ghannam N (2016) Antibacterial derivatives of marine algae: An overview of pharmacological mechanisms and applications. Mar Drugs 14(4): 81. https://doi.org/10.3390/md14040081
Shin ES, Hwang HJ, Kim IH, Nam TJ (2011) A glycoprotein from Porphyra yezoensis produces anti-inflammatory effects in liposaccharide-stimulated macrophages via the TLR4 signaling pathway. Int J Mol Med 28(5): 809–815. https://doi.org/10.3892/ijmm.2011.729
Silva A, Silva SA, Carpena M, Garcia-Oliveira P, Gullón P, Barroso MF, Prieto MA, Simal-Gandara J (2020a) Macroalgae as a source of valuable antimicrobial compounds: Extraction and applications. Antibiotics 9(10): 642. https://doi.org/10.3390/antibiotics9100642
Silva A, Silva SA, Lourenço-Lopes C, Jimenez-Lopez C, Carpena M, Gullón P, Fraga-Corral M, Domingues VF, Fátima Barroso M, Simal-Gandara J, Prieto MA (2020b) Antibacterial use of macroalgae compounds against foodborne pathogens. Antibiotics 9(10): 712. https://doi.org/10.3390/antibiotics9100712
Silva LMCM, Lima V, Holanda ML, Pinheiro PG, Rodrigues JAG, Lima MEP, Benevides NMB (2010) Antinociceptive and anti-inflammatory activities of lectin from marine red alga Pterocladiella capillacea. Biol Pharm Bull 33(5): 830–835. https://doi.org/10.1248/bpb.33.830
Simsek M, Sumnu G, Sahin S (2012) Microwave assisted extraction of phenolic compounds from sour cherry pomace. Sep Sci Technol 47(8): 1248–1254. https://doi.org/10.1080/01496395.2011.644616
Sivagnanam SP, Yin S, Choi JH, Park YB, Woo HC, Chun BS (2015) Biological properties of fucoxanthin in oil recovered from two brown seaweeds using supercritical CO2 extraction. Mar Drugs 13(6): 3422–3442. https://doi.org/10.3390/md13063422
Sosa-Hernández JE, Escobedo-Avellaneda Z, Iqbal HMN, Welti-Chanes J (2018) State-of-the-art extraction methodologies for bioactive compounds from algal biome to meet bio-economy challenges and opportunities. Molecules 23(11): 2953. https://doi.org/10.3390/molecules23112953
Stack J, Tobin PR, Gietl A, Harnedy PA, Stengel DB, FitzGerald RJ (2017) Seasonal variation in nitrogenous components and bioactivity of protein hydrolysates from Porphyra dioica. J Appl Phycol 29(5): 2439–2450. https://doi.org/10.1007/s10811-017-1063-0
Sun H, Ge X, Lv Y, Wang A (2012) Application of accelerated solvent extraction in the analysis of organic contaminants, bioactive and nutritional compounds in food and feed. J Chromatogr A 1237: 1–23. https://doi.org/10.1016/j.chroma.2012.03.003
Sun Y, Gong G, Guo Y, Wang Z, Song S, Zhu B, Zhao L, Jiang J (2018) Purification, structural features and immunostimulatory activity of novel polysaccharides from Caulerpa lentillifera. Int J Biol Macromol 108: 314–323. https://doi.org/10.1016/j.ijbiomac.2017.12.016
Sun Y, Liu Z, Song S, Zhu B, Zhao L, Jiang J, Liu N, Wang J, Chen X (2019) Anti-inflammatory activity and structural identification of a sulfated polysaccharide CLGP4 from Caulerpa lentillifera. Int J Biol Macromol 146: 931–938. https://doi.org/10.1016/j.ijbiomac.2019.09.216
Tanna B, Brahmbhatt HR, Mishra A (2019) Phenolic, flavonoid, and amino acid compositions reveal that selected tropical seaweeds have the potential to be functional food ingredients. J Food Process Preserv 43(12): 1–10. https://doi.org/10.1111/jfpp.14266
Thomas NV, Kim SK (2011) Potential pharmacological applications of polyphenolic derivatives from marine brown algae. Environ Toxicol Pharmacol 32(3): 325–335. https://doi.org/10.1016/j.etap.2011.09.004
Tierney MS, Smyth TJ, Hayes M, Soler-Vila A, Croft AK, Brunton N (2013) Influence of pressurised liquid extraction and solid-liquid extraction methods on the phenolic content and antioxidant activities of Irish macroalgae. Int J Food Sci Technol 48(4): 860–869. https://doi.org/10.1111/ijfs.12038
Tiwari BK (2015) Ultrasound: A clean, green extraction technology. Trends Anal Chem 71: 100–109. https://doi.org/10.1016/j.trac.2015.04.013
Topuz OK, Gokoglu N, Yerlikaya P, Ucak I, Gumus B (2016) Optimization of antioxidant activity and phenolic compound extraction conditions from red seaweed (Laurencia obtuse). J Aquat Food Prod Technol 25(3). 414–422. https://doi.org/10.1080/10498850.2013.868844
Tsubaki S, Oono K, Hiraoka M, Onda A, Mitani T (2016) Microwave-assisted hydrothermal extraction of sulfated polysaccharides from Ulva spp and Monostroma latissimum. Food Chem 210: 311–316. https://doi.org/10.1016/j.foodchem.2016.04.121
Valko M, Leibfritz D, Moncol J, Cronin MTD, Mazur M, Telser J (2007) Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39(1): 44–84. https://doi.org/10.1016/j.biocel.2006.07.001
Vanderlei ESO, Patoilo KKNR, Lima NA, Lima APS, Rodrigues JAG, Silva LMCM, Lima MEP, Lima V, Benevides NMB (2010) Antinociceptive and anti-inflammatory activities of lectin from the marine green alga Caulerpa cupressoides. Int Immunopharmacol 10(9): 1113–1118. https://doi.org/10.1016/j.intimp.2010.06.014
Vieira EF, Soares C, Machado S, Correia M, Ramalhosa MJ, Oliva-teles MT, Paula CA, Domingues VF, Antunes F, Oliveira TAC, Morais S, Delerue MC (2018) Seaweeds from the Portuguese coast as a source of proteinaceous material: Total and free amino acid composition profile. Food Chem 269: 264–275. https://doi.org/10.1016/j.foodchem.2018.06.145
Vijay SNP, Jagtap AS, Baghel RS, Imchen T, Manohar CS (2023) Elucidation of the antioxidant potential of marine macroalgal biomolecules for healthcare applications: Current status and future prospects. In: Marine Antioxidants: Preparations, Syntheses, and Applications. Academic Press, pp. 365–377. https://doi.org/10.1016/B978-0-323-95086-2.00027-8
Wang Z, Sun Q, Zhang H, Wang J, Fu Q, Qiao H, Wang Q (2021) Insight into antibacterial mechanism of polysaccharides: A review. LWT 150: 111929. https://doi.org/10.1016/j.lwt.2021.111929
Wan-Loy C, Siew-Moi P (2016) Marine algae as a potential source for anti-obesity agents. Mar Drugs 14(12): 222. https://doi.org/10.3390/md14120222
Wells ML, Potin P, Craigie JS, Raven JA, Merchant SS, Helliwell KE, Smith AG, Camire ME, Brawley SH (2017) Algae as nutritional and functional food sources: revisiting our understanding. J Appl Phycol 29(2): 949–982. https://doi.org/10.1007/s10811-016-0974-5
Xiao X, Si X, Yuan Z, Xu X, Li G (2012) Isolation of fucoxanthin from edible brown algae by microwave-assisted extraction coupled with high-speed countercurrent chromatography. J Sep Sci 35(17): 2313–2317. https://doi.org/10.1002/jssc.201200231
Xu SY, Huang X, Cheong KL (2017) Recent advances in marine algae polysaccharides: Isolation, structure, and activities. Mar Drugs 15(12): 388. https://doi.org/10.3390/md15120388
Yuan Y, Zhang J, Fan J, Clark J, Shen P, Li Y, Zhang C (2018) Microwave assisted extraction of phenolic compounds from four economic brown macroalgae species and evaluation of their antioxidant activities and inhibitory effects on α-amylase, α-glucosidase, pancreatic lipase and tyrosinase. Food Res Int 113: 288–297. https://doi.org/10.1016/j.foodres.2018.07.021
Zhang HF, Yang XH, Wang Y (2011) Microwave assisted extraction of secondary metabolites from plants: Current status and future directions. Trends Food Sci Technol 22(12): 672–688. https://doi.org/10.1016/j.tifs.2011.07.003
Zhang R, Yuen AKL, Magnusson M, Wright JT, de Nys R, Masters AF, Maschmeyer T (2018) A comparative assessment of the activity and structure of phlorotannins from the brown seaweed Carpophyllum flexuosum. Algal Res 29: 130–141. https://doi.org/10.1016/j.algal.2017.11.027
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