J Pharm Pharmacogn Res 3(suppl. 1): S187, 2015
Proceedings of the 4th International Symposium on Pharmacology of Natural Products FAPRONATURA 2015 September 21st-25th, 2015; Cuban Society of Pharmacology. Topes de Collantes, Sancti Spiritus, Cuba.
POS-94: METHODOLOGY FOR DEVELOP A NATURAL PRODUCT IN THE FORM OF TROCHES: “MENTISAN”
Lemus Z, Vigo M, Nápoles R, Rodríguez M, Chong A.
Introduction: Troches are tablets manufactured by compression, designed to dissolve or slowly erode at the oral cavity because they are intended to exert a local effect in the mouth or throat. This special type of tablets, which should be pleasant for the consumer, is commonly used to combat halitosis and to treat sore throat or to control coughing in the common cold, offering a bigger quality of life to the population. Appreciating the perspective of utilization of essential oils obtained from some medicinal plants at our country (specifically from Pinar del Río), as well as evaluating the feasibility of troches production in the manufacturing conditions of the Pharmaceutical Laboratory Oriente, Objectives: To establish a methodology for develop a pharmaceutical product in the form of troches with anesthetic, antiseptic and antibacterial actions based on the use of the national essential oils of natural origin. Material and methods: The active ingredients were menthol, eucalyptol, thymol and eugenol; a flavoring agent, peppermint oil, and excipients of pharmaceutical quality certificated by the USP/BP Pharmacopoeias. For analyzing, the finished product validated identification and semi-quantification methods by thin layer chromatography were used. Wet granulation was used for manufacturing troches. Results: A product in the pharmaceutical dosage form of troches was obtained, which for its design and formulation and adequate texture, aroma and taste, proves to be effective and pleasant, fulfilling the quality specifications established. The stability evaluated allowed a period of initial validity of one year. Conclusions: The obtained product, which commercial check mark is <Trociscos MENTISAN>, was registered by the Cuban Regulatory Authority. Its large-scale production proves to be feasible, with the guaranty of quality that offers an industrial pharmaceutical product, and the resulting technical- economic and social impacts.
Citation Format: Lemus Z, Vigo M, Nápoles R, Rodríguez M, Chong A (2015) Methodology for develop a natural product in the form of troches: “Mentisan”. [Abstract]. In: Proceedings of the FAPRONATURA 2015; 2015 Sep 21-25; Topes de Collantes, Sancti Spiritus: CSF. J Pharm Pharmacogn Res 3(Suppl. 1): S187. Abstract nr POS-94.